Could a blood pressure drug ease Veterans' Post-Concussion headaches?
NCT ID NCT02266329
First seen Apr 03, 2026 · Last updated Jun 23, 2026 · Updated 12 times
Summary
This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headache frequency, severity, and impact on daily life to see if prazosin outperformed the placebo.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, 98108-1532, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prazosin (a blood pressure medicine also used for nightmares)
What this could lead to
If prazosin works, it could offer a new way to ease chronic headaches after mild traumatic brain injury in veterans and service members.
What could go wrong
This is an early-phase trial with only 89 participants, so results may not apply to everyone. Prazosin can cause dizziness, low blood pressure, and fainting.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.