Shocking migraine away: nerve zap plus stress relief shows promise
NCT ID NCT03592329
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether combining a gentle electrical nerve stimulation device (tVNS) with stress reduction training can ease migraine. Researchers measured brain activity and inflammation in 193 adults with migraine before and after 8 weeks of treatment. The goal was to see if this combo changes how the brain processes pain and reduces migraine attacks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcutaneous vagus nerve stimulation (tVNS) device and stress reduction training
What this could lead to
If it works, this could point toward a non-drug combination therapy for migraine that targets brain pathways and inflammation.
What could go wrong
This is a completed early-stage study with no phase, so results may not confirm effectiveness. The approach combines two interventions, making it hard to know which part helps.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Anthinoula A. Martinos Center
Charlestown, Massachusetts, 02129, United States