New combo therapy for chronic migraine: atogepant plus botox under study

NCT ID NCT05216263

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effects, lab values, and migraine changes. The study is complete, but results are not yet published.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atogepant (QULIPTA) oral tablet
What this could lead to: If successful, this could show that adding atogepant to Botox provides better migraine prevention than Botox alone, offering a new combination treatment option.
What could go wrong: This is an open-label study with no placebo group, so results may be less reliable. Side effects like nausea, constipation, or suicidal thoughts are possible. The small size (75 people) limits generalizability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

Locations

Albany Medical College /ID# 242757

Albany, New York, 12208, United States
Arkansas Clinical Research /ID# 241789

Little Rock, Arkansas, 72205, United States
Barrow Neurological Institute - Dignity Health St. Joseph's Hosp and Medical Ctr /ID# 241812

Phoenix, Arizona, 85013, United States
Beth Israel Deaconess Medical Center /ID# 241800

Boston, Massachusetts, 02215-5400, United States
Chattanooga Medical Research /ID# 253295

Chattanooga, Tennessee, 37404-3239, United States
Coastal Clinical Research Specialists /ID# 247992

Jacksonville Beach, Florida, 32250-1694, United States
Dent Neurologic Institute - Amherst /ID# 241776

Amherst, New York, 14226, United States
Duplicate_Ochsner Clinic Foundation /ID# 241803

Covington, Louisiana, 70433-8107, United States
First Physicians Group - Waldemere /ID# 242861

Sarasota, Florida, 34239-2943, United States
Frontier Clinical Research - Kingwood /ID# 242928

Kingwood, West Virginia, 26537-9797, United States
Headache Wellness Center /ID# 241791

Greensboro, North Carolina, 27405, United States
Hope Clinical Research /ID# 241772

Canoga Park, California, 91303, United States
Inova Health System /ID# 252242

Falls Church, Virginia, 22042, United States
Integrated Neurology Services - Falls Church /ID# 244747

Falls Church, Virginia, 22043-2367, United States
Jefferson Hospital for Neuroscience /ID# 243712

Philadelphia, Pennsylvania, 19107-5191, United States
Kansas Institute of Research /ID# 241796

Overland Park, Kansas, 66211-1363, United States
Michigan Headache & Neurological Institute (MHNI) /ID# 241784

Ann Arbor, Michigan, 48104-5131, United States
Minneapolis Clinic of Neurology - Burnsville /ID# 241994

Burnsville, Minnesota, 55337-6732, United States
Nashville Neuroscience Group /ID# 243592

Nashville, Tennessee, 37203, United States
Neuro Pain Medical Center /ID# 241992

Fresno, California, 93710, United States
Neurological Research Institute /ID# 242688

Santa Monica, California, 90404, United States
Neurology Offices of South Florida, PLLC /ID# 242693

Boca Raton, Florida, 33428-2231, United States
Neurology and Neurodiagnostics of Alabama /ID# 242538

Hoover, Alabama, 35244-5700, United States
Preferred Primary Care Physicians - Jacob Murphy /ID# 241798

Uniontown, Pennsylvania, 15401, United States
Profound Research LLC /ID# 244084

Carlsbad, California, 92011-4213, United States
Puget Sound Neurology /ID# 241787

Tacoma, Washington, 25328, United States
Texas Neurology /ID# 241795

Dallas, Texas, 75214, United States
University of Miami /ID# 252230

Miami, Florida, 33136, United States
West Virginia Univ School Med /ID# 252869

Morgantown, West Virginia, 26506, United States

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