New migraine drug cuts headache hours in half for those failed by other treatments

NCT ID NCT04252742

Completed Symptom relief Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Apr 11, 2026 · Last updated May 12, 2026 · Updated 5 times

Summary

This study tested the drug erenumab in 512 adults with high-frequency episodic migraine (7 to 14 migraine days per month) who had already tried at least one other preventive treatment without success. The main goal was to see if erenumab could reduce the total hours of moderate-to-severe headache pain each month over three months. Results showed a significant decrease in headache hours compared to placebo, along with improvements in daily physical functioning.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

American Clinical Research Institute LLC

Beavercreek, Ohio, 45432, United States
AppleTreeClinics Network Spzoo

Lodz, 90-349, Poland
Azienda Ospedaliera Universitaria Renato Dulbecco

Catanzaro, 88100, Italy
Azienda Socio Sanitaria Teritoriale Spedali Civili di Brescia

Brescia, 25123, Italy
Azienda della scienza di Torino

Torino, 10126, Italy
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
Brain-soultherapy sro

Kladno, 272 01, Czechia
Campus Neurologico Senior

Torres Vedras, 2560-280, Portugal
Care Clinic Spzoo Care Clinic Centrum Medyczne

Katowice, 40-568, Poland
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria

Lisbon, 1649-035, Portugal
Centrum Badan Klinicznych PI-House Spzoo

Gdansk, 80-546, Poland
Centrum Medyczne Oporow

Wroclaw, 52-416, Poland
Chicago Headache Center and Research Institute

Chicago, Illinois, 60657, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clinical Research Institute, LLC

Los Angeles, California, 90048, United States
Clinvest Research LLC

Springfield, Missouri, 65810, United States
Dado Medical sro

Prague, 120 00, Czechia
Dent Neurosciences Research Center

Amherst, New York, 14226, United States
Denver Neurological Clinic

Denver, Colorado, 80210, United States
FORBELI sro

Prague, 160 00, Czechia
Fakultni nemocnice u svate Anny v Brne

Brno, 656 91, Czechia
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Fondazione Istituto Neurologico Nazionale C Mondino IRCCS

Pavia, 27100, Italy
Forte Family Practice

Las Vegas, Nevada, 89103, United States
FutureSearch Trials of Neurology

Austin, Texas, 78731, United States
Gabinet Diagnostyki i Leczenia Osteoporozy Prof Wojciech Pluskiewicz

Gliwice, 44-100, Poland
Heuer Medical Doctor Research LLC

Orlando, Florida, 32819, United States
High Tech Medical Kft

Budapest, 1064, Hungary
Hospital Clinico Universitario Lozano Blesa

Zaragoza, Aragon, 50009, Spain
Hospital Clinico Universitario de Valencia

Valencia, Valencia, 46010, Spain
Hospital Clinico Universitario de Valladolid

Valladolid, Castille and León, 47010, Spain
Hospital Cuf Sintra

Sintra, 2710-204, Portugal
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitari i Politecnic La Fe

Valencia, Valencia, 46026, Spain
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
Hospital Universitario Virgen del Rocio

Seville, Andalusia, 41013, Spain
Hospital da Luz, SA

Lisbon, 1500-650, Portugal
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
IRCCS San Raffaele Pisana

Roma, 00163, Italy
Institut Neuropsychiatricke pece

Prague, 186 00, Czechia
Instytut Zdrowia Dr Boczarska-Jedynak Spzoo SpKom

Oświęcim, 32-600, Poland
JEM Research Institute

Atlantis, Florida, 33462, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
Long Beach Clinical Trials Services Inc

Long Beach, California, 90806, United States
M-Zdrowie

Lodz, 91-072, Poland
Medical Center Excelsior OOD

Sofia, 1407, Bulgaria
Medical Center New Rehabilitation Center EOOD

Stara Zagora, 6000, Bulgaria
Mercy Health Research

St Louis, Missouri, 63141, United States
Michigan Head Pain and Neurological Institute

Ann Arbor, Michigan, 48104, United States
Migre Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak

Wroclaw, 52-210, Poland
Mountain Neurological Research Center

Basalt, Colorado, 81621, United States
Multiprofile Hospital for Active Treatment in neurology and psychiatry Sveti Naum EAD

Sofia, 1113, Bulgaria
NZOZ Neuromed M i M Nastaj Spolka Partnerska

Kraśnik, 23-210, Poland
NZOZ Neuromed M i M Nastaj Spolka Partnerska

Lublin, 20-064, Poland
Nashville Neuroscience Group

Nashville, Tennessee, 37203, United States
NeuroMed Zlin sro

Zlín, 760 01, Czechia
Neurologie Brno sro

Brno, 616 00, Czechia
Neurology Associates of Ormond Beach

Ormond Beach, Florida, 32174, United States
New England Regional Headache Center Inc

Worcester, Massachusetts, 14226, United States
North Texas Institute of Neurology and Headache

Frisco, Texas, 75034, United States
Obudai Egeszsegugyi Centrum Kft

Budapest, 1036, Hungary
Obudai Egeszsegugyi Centrum Kft

Zalaegerszeg, 8900, Hungary
Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti Intezet

Budapest, 1145, Hungary
Ospedale Bellaria Carlo Alberto Pizzardi

Bologna, 40139, Italy
Ospedale Policlinico San Martino IRCCS

Genoa, 16132, Italy
Osrodek Badan Klinicznych Cromed

Poznan, 61-360, Poland
Palmetto Clinical Trial Services

Greenville, South Carolina, 29615, United States
Papillion Research Center

Papillion, Nebraska, 68046, United States
Policlinico Universitario Campus Biomedico

Roma, 00128, Italy
Poliklinika Chocen, Neurohk sro

Choceň, 565 01, Czechia
Prywatny Gabinet Neurologiczny Iwona Rosciszewska-Zukowska

Rzeszów, 35-301, Poland
Renstar Medical Research

Ocala, Florida, 34470, United States
S-Medicon Kutatasi Centrum

Budapest, 1138, Hungary
Saint Lukes Clinic

Meridian, Idaho, 83642, United States
Spitalul Clinic Judetean de Urgenta Pius Brinzeu Timisoara

Timișoara, 700736, Romania
Spitalul Universitar de Urgenta Bucuresti

Bucharest, 050098, Romania
Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila

Bucharest, 010825, Romania
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
Summit Headache and Neurologic Institute

Englewood, Colorado, 80113, United States
Summit Research Network

Portland, Oregon, 97210, United States
University First Multiprofile Hospital for Active Treatment - Sofia Sveti Yoan Krastitel EAD

Sofia, 1154, Bulgaria
University Multiprofile Hospital for Active Treatment - Dr Georgi Stranski EAD

Pleven, 5800, Bulgaria
University Multiprofile Hospital for Active Treatment Alexandrovska EAD

Sofia, 1431, Bulgaria
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

Plovdiv, 4001, Bulgaria
University of Cincinnati

Cincinnati, Ohio, 45229, United States
Uno Medical Trials Kft

Budapest, 1135, Hungary
Visionary Investigators Network

Miami, Florida, 33133, United States
Visionary Investigators Network

Pembroke Pines, Florida, 33026, United States
Vistamed and Vertigo Sp z o o

Wroclaw, 53-149, Poland
Vita Longa Spzoo

Katowice, 40-748, Poland

Conditions

Explore the condition pages connected to this study.

MIGRAINE