New hope for migraine sufferers: rimegepant shows promise in prevention trial

NCT ID NCT05518123

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 4 study tested whether rimegepant, a dissolvable tablet taken every other day, can prevent migraines in adults who did not get enough relief from other oral preventive medications. Over 960 participants were enrolled. The main goal was to see if rimegepant reduces the number of migraine days per month compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

rimegepant (a pill that dissolves in the mouth, taken every other day)

What this could lead to

If successful, this could offer a new preventive option for people with migraines who haven't been helped by existing oral medications.

What could go wrong

This is a phase 4 study, so the drug is already approved; however, it may not work for everyone, and side effects or lack of benefit are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Headache migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Locations

4 Medical Clinical Solutions

Swinton, M27 8FF, United Kingdom
4 Medical Clinical Solutions London

Ilford, Essex, IG1 4HP, United Kingdom
ALPHA Recherche Clinique

Québec, Quebec, G3K 2P8, Canada
ALPHA Recherche Clinique

Québec, G2J 0C4, Canada
AOU Luigi Vanvitelli

Naples, Naples, 80134, Italy
AZ Sint-Jan Brugge-Oostende AV

Bruges, 8000, Belgium
Aggarwal and Associates Limited

Brampton, Ontario, L6T 0G1, Canada
Akardo Med Site

Stockholm, 117 27, Sweden
Albuquerque Clinical Trials. Inc.

Albuquerque, New Mexico, 87102, United States
Alliance for Multispecialty Reseach, LLC

Knoxville, Tennessee, 37909, United States
AppleMed Research Group, LLC

Miami, Florida, 33126, United States
Bispebjerg Hospital

Copenhagen NV, Capital Region, 2400, Denmark
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
CTC MTC

Uppsala, Uppsala LÄN [se-03], 752 37, Sweden
CTC Solna

Solna, Stockholms LÄN [se-01], 171 64, Sweden
Cabinet Privé Dr. Simona Sava

Saint Nicolas Province de Liège, 4420, Belgium
California Neuroscience Research, LLC

Sherman Oaks, California, 91403, United States
Carlanderska Hospital

Gothenburg, 40545, Sweden
Centermed Kraków Sp. Z o.o.

Krakow, Malopolska, 31-530, Poland
Centre de Recherche Saint-Louis/Clinique Neuro-Levis

Lévis, Quebec, G6W0M5, Canada
Centro de Investigación Médica de Aguascalientes (CIMA)

Aguascalientes, 20116, Mexico
Centrum Leczenia Bolu dr n med Lukasz Kmieciak

Lodz, Łódź Voivodeship, 91-363, Poland
Centrum Medyczne Neuromed

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-163, Poland
Centrum Medyczne OPOROW

Wroclaw, 52-416, Poland
Centrum Medyczne Pratia Katowice

Katowice, 40-081, Poland
Clinical Research Institute

Los Angeles, California, 90048, United States
Clinical Research Institute S.C.

Tlalnepantla, State of Mexico, C.P. 54055, Mexico
Clinique de la Citadelle

Liège, 4000, Belgium
Clinstile, SA de CV

Mexico City, CDMX 06700, Mexico
Clinvest Research, LLC

Springfield, Missouri, 65807, United States
Cognition Health - Bristol

Bristol, BS32 4SY, United Kingdom
Community Clinical Research Network, Inc.

Marlborough, Massachusetts, 01752, United States
Concept Medica

Warsaw, Masovian Voivodeship, 00-773, Poland
Consorcio Hospital General Universitario

Valencia, 46014, Spain
DM Clinical Research

Tomball, Texas, 77375, United States
Danish Headache Center

Glostrup Municipality, Capital Region, 2600, Denmark
DiGiovanna Institute for Medical Education And Research

North Massapequa, New York, 11758, United States
Dr Sekowska Leczenie Bolu

Warsaw, Masovian Voivodeship, 01-018, Poland
GZA Ziekenhuizen

Antwerp, 2610, Belgium
Headache Wellness Center, PC

Greensboro, North Carolina, 27405, United States
Hospital Clinic de Barcelona Plato Headquarters

Barcelona, 08006, Spain
Hospital Clinico Universitario de Valladolid

Valladolid, 47010, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Ruber Juan Bravo

Salamanca, 28006, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen Macarena

Seville, 41009, Spain
Hospital Universitario de Elda

Elda, Alicante, 03600, Spain
Hospital Universitario de La Princesa

Madrid, 28006, Spain
Hospitalsenhed Midt

Viborg, DK-8800, Denmark
Hull University Hospitals NHS Trust

Hull, EAST Riding, HU3 2JZ, United Kingdom
Hälsoklustret

Stockholm, 112 39, Sweden
IRCCS Fondazione Besta

Milan, 20133, Italy
IRCCS Fondazione Istituto Neurologico Nazionale C. Mondino

Pavia, Lombardy, 27100, Italy
IRCCS Ospedale San Raffaele

Milan, MI, 20132, Italy
IRCCS San Raffaele

Rome, Rome/lazio, 00163, Italy
Instytut Zdrowia

Oświęcim, Małopolska, 32-600, Poland
Intermed GmbH

Wiesbaden, Hesse, 65189, Germany
James Paget University Hospitals NHS Foundation Trust

Great Yarmouth, Norfolk, NR31 6LA, United Kingdom
Jessa Ziekenhuis

Hasselt, 3500, Belgium
Ki Health Partners LLC, dba New England Institute for Clinical Research

Stamford, Connecticut, 06905, United States
Kings College London

London, SE5 9PJ, United Kingdom
Klinikum Klagenfurt am Wörthersee

Klagenfurt, 9020, Austria
Kopfschmerzzentrum Frankfurt

Frankfurt am Main, Hesse, 65929, Germany
Lakeside Healthcare Group Research

Corby, Northamptonshire, NN17 2UR, United Kingdom
MICS Centrum Medyczne Damiana Walbrzyska

Warsaw, Masovian Voivodeship, 02-739, Poland
MICS Centrum Medyczne Szczecin

Szczecin, 70-784, Poland
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
MTZ Clinical Research Powered by Pratia

Warsaw, 02-172, Poland
Medical Care and Research S.A. de C.V.

Mérida, Yucatán, CP. 97070, Mexico
Medical University Innsbruck

Innsbruck, Tyrol, 6020, Austria
Michigan Headache & Neurological Institute

Ann Arbor, Michigan, 48104, United States
NeuPath Centre for Pain and Spine

Brampton, Ontario, L6V 1C2, Canada
Neuropoint GmbH

Ulm Baden-Wuerttemberg, 89073, Germany
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Operadora Unidad de Investigación En Salud de Chihuahua, Sa de Cv

Mexico City, CP 14050, Mexico
Phylasis Clinicas Research S. de R.L. de C.V.

Cuautitlán Izcalli, State of Mexico, 54769, Mexico
Premium Clinic Wrocław

Wroclaw, 50-414, Poland
Queen Elizabeth University Hospital

Glasgow, Scotland, G51 4TF, United Kingdom
Re: Cognition Health Ltd.

Edgebaston, Birmingham, B16 8LT, United Kingdom
Red Star Research, LLC

Lake Jackson, Texas, 77566, United States
Rochester Medical Group

Rochester Hills, Michigan, 48307, United States
SOD Centro Cefalee e Farmacologia Clinica, AOU Careggi

Florence, 50134, Italy
Sandhill Research, LLC d/b/a Accel Research Sites Network - Ormond Clinical Research Unit

Ormond Beach, Florida, 32174, United States
Sandhill Research, LLC d/b/a Accel Research Sites Network-Edgewater Clinical Research Unit

Edgewater, Florida, 32132, United States
Schmerz- und Palliativzentrum Göppingen

Göppingen, Baden-Wurttemberg, 73033, Germany
Sensible Healthcare LLC

Ocoee, Florida, 34761, United States
Skåneuro Privatmottagning

Lund, 222 22, Sweden
St Charles Clinical Research

Weldon Spring, Missouri, 63304, United States
Studienzentrum Nordwest

Westerstede, Lower Saxony, 26655, Germany
Synexus - Prüfzentrum Berlin

Berlin, 12672, Germany
Synexus - Prüfzentrum Leipzig

Leipzig, Saxony, 04103, Germany
Synexus Clinical Research GmbH Synexus Frankfurt Clinical Research Centre

Frankfurt am Main, Hesse, 60313, Germany
Synexus Clinical Research US, Inc. - Anderson

Anderson, South Carolina, 29621, United States
Terveystalo Pulssi

Turku, 20100, Finland
Terveystalo Ruoholahti

Helsinki, Uusimaa, 00180, Finland
Terveystalo Tampere

Tampere, 33100, Finland
Twoja Przychodnia Nowosolskie Centrum Medyczne

Nowa Sól, Lubusz Voivodeship, 67-100, Poland
USC Clinical Trials Sunshine Coast

Sippy Downs, Queensland, 4556, Australia
UZ Brussel

Jette, Brussels Capital, 1090, Belgium
University Hospital Marqués de Valdecilla

Santander, 39008, Spain
University Hospital Uppsala (VO Neuro)

Uppsala, 75185, Sweden
University Hospital of Southern Denmark

Esbjerg, DK-6700, Denmark
University Modena e Reggio Emilia

Modena, 41124, Italy
Virgen del Rocio University Hospital

Seville, 41013, Spain
Vita Longa Sp. Z o.o.

Katowice, 40-748, Poland
Wr-Crcn, Llc

Las Vegas, Nevada, 89118, United States
Wr-Msra,Llc

Lake City, Florida, 32055, United States
Zentrum für klinische Forschung

Bad Homburg, Hesse, 61350, Germany