Could migraine meds silence tinnitus? new trial investigates
NCT ID NCT04404439
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these drugs improve tinnitus symptoms, as measured by the Tinnitus Functional Index.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nortriptyline + Topiramate, or Verapamil + Paroxetine
What this could lead to
If successful, this could point toward a new medication option to ease tinnitus symptoms and improve quality of life.
What could go wrong
This is a small Phase 4 trial with only 78 participants, so results may not apply to everyone. The drugs also have side effects and may not work better than placebo.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TINNITUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University of California, Irvine Medical Center ENT Clinic (Pavilion 2)
Orange, California, 92868, United States