Could migraine meds silence tinnitus? new trial investigates

NCT ID NCT04404439

Completed Symptom relief Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these drugs improve tinnitus symptoms, as measured by the Tinnitus Functional Index.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nortriptyline + Topiramate, or Verapamil + Paroxetine
What this could lead to: If successful, this could point toward a new medication option to ease tinnitus symptoms and improve quality of life.
What could go wrong: This is a small Phase 4 trial with only 78 participants, so results may not apply to everyone. The drugs also have side effects and may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TINNITUS TINNITUS, SUBJECTIVE

Contacts and locations

Locations

University of California, Irvine Medical Center ENT Clinic (Pavilion 2)

Orange, California, 92868, United States

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