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Sniffing out migraines: smell sensitivity may be key clue

NCT ID NCT07329127

Knowledge-focused Sponsor: National and Kapodistrian University of Athens Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study looked at 210 people with migraine or tension-type headache to see if a strong dislike of smells (osmophobia) is a reliable sign of migraine. Participants tracked their headaches and smell sensitivity for six months using diaries and questionnaires. The goal was to understand how common osmophobia is in each headache type and whether it can help doctors diagnose migraine more accurately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

210 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients visiting the Headache Outpatient Department of Eginition Hospital of Athens

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with a diagnosis of migraine or tension-type headache (ICHD-3) 2. Age \>16 years 3. Patients with or without medication overuse headache 4. Patients with or without prophylaxis 5. Patients with or without comorbidity with mood disorders 6. Patients will have signed informed consent to participate in the study Exclusion Criteria: 1. Patients with primary or secondary anosmia 2. Inability to obtain written consent

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Conditions

The condition(s) this trial relates to.

headache disorder migraine disorder Tension-Type Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine Tension headache

Contacts and locations

Locations

  • Aeginition Hospital of Athens

    Athens, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.