New pill elismetrep aims to zap migraine pain in Mid-Stage trial

NCT ID NCT06848075

Completed Symptom relief Sponsor: Kallyope Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed Phase IIb trial tested an oral drug called elismetrep (K-304) in 431 adults with moderate or severe migraine. Participants received one of four doses of elismetrep or a placebo. The main goal was to see if the drug could make pain disappear within a set time. Secondary goals included relief from the most bothersome symptom, such as nausea or sensitivity to light or sound. The study was double-blind and placebo-controlled to ensure fair results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elismetrep (K-304)
What this could lead to: If successful, elismetrep could offer a new oral option to relieve migraine pain and bothersome symptoms like nausea or light sensitivity.
What could go wrong: This is a Phase IIb trial, so results are still early. The drug may not prove better than placebo, and side effects or lack of lasting benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MIGRAINE

Contacts and locations

Locations

AMR Knoxville (Formerly NOCCR)

Knoxville, Tennessee, 37909, United States
AMR Mobile

Mobile, Alabama, 36608, United States
APD Clinical Research

Splendora, Texas, 77372, United States
Acclaim Clinical Research

San Diego, California, 89109, United States
Advanced Research Institute

Ogden, Utah, 84405, United States
Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, 87102, United States
Alliance for Multispecialty Research

Wichita, Kansas, 67207, United States
Artemis Institute for Clinical Research - Riverside

Riverside, California, 92503, United States
Artemis Institute for Clinical Research - San Diego

San Diego, California, 92103, United States
Atlas-Clinical

West Chester, Pennsylvania, 19380, United States
CNY Clinical Research

Manlius, New York, 13104, United States
CT Clinical Research

Cromwell, Connecticut, 06416, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Cedar Crosse Research Center

Chicago, Illinois, 60607, United States
Central Research Associates, LLC (CRA) dba Flourish Research

Birmingham, Alabama, 35205, United States
ClinPoint Trials

Waxahachie, Texas, 75165, United States
Clinical Investigation Specialist

Kenosha, Wisconsin, 53144, United States
Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
Clinical Research Atlanta - Stockbridge

Stockbridge, Georgia, 30281, United States
Clinical Research Institute

Minneapolis, Minnesota, 55402, United States
Clinical Research Philadelphia, LLC

Philadelphia, Pennsylvania, 19114, United States
Clinical Trials of South Carolina

Charleston, South Carolina, 29406, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Collective Medical Research

Overland Park, Kansas, 66202, United States
Crescent City Headache & Neurology Center

Chalmette, Louisiana, 70043, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Gulfport, Mississippi, 39503, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
Dent Neurosciences Research Center

Amherst, New York, 14226, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
Donald J Garcia Jr, MD, PA

Austin, Texas, 78737, United States
Empire Clinical Research

Pomona, California, 91767, United States
Excel Clinical Research

Las Vegas, Nevada, 89109, United States
Excell Research, Inc.

Oceanside, California, 92056, United States
Eximia Research - CA

La Mesa, California, 91942, United States
Focus Clinical Research

West Hills, California, 91307, United States
Frontier Clinical Research, LLC

Scottdale, Pennsylvania, 15683, United States
Frontier Clinical Research, LLC

Smithfield, Pennsylvania, 15478, United States
Frontier Clinical Research, LLC

Morgantown, West Virginia, 26505, United States
FutureSearch Trials of Dallas, LP

Dallas, Texas, 75251, United States
Headache Wellness Center

Greensboro, North Carolina, 27405, United States
Health Research of Hampton Roads, Inc.

Newport News, Virginia, 23606, United States
Healthcare Research Network

Hazelwood, Missouri, 63042, United States
Healthcare Research Network II, LLC

Flossmoor, Illinois, 60422, United States
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
Hope Clinical Research

Canoga Park, California, 91303, United States
L-MARC Research Center

Louisville, Kentucky, 40213, United States
Las Vegas Clinical Trials

North Las Vegas, Nevada, 89119, United States
Lehigh Center for Clinical Research

Allentown, Pennsylvania, 18103, United States
Marvel Clinical Research

Huntington Beach, California, 92647, United States
Michigan Head Pain and Neurological Institute

Ann Arbor, Michigan, 48104, United States
Northwest Clinical Trials

Boise, Idaho, 83704, United States
OK Clinical Research, LLC

Edmond, Oklahoma, 73034, United States
Peters Medical Research

High Point, North Carolina, 27260, United States
Rochester Clinical Research

Rochester, New York, 14609, United States
Summit Research Network

Portland, Oregon, 97210, United States
Synergy San Diego

Lemon Grove, California, 91945, United States
Tekton Research

Yukon, Oklahoma, 73099, United States
Tekton Research

Austin, Texas, 78745, United States
Upstate Clinical Research Associates LLC

Williamsville, New York, 14221, United States
Victorium Clinical Research LTD CO

Houston, Texas, 77024, United States
WR-ClinSearch

Chattanooga, Tennessee, 37421, United States
WR-PRI, LLC (Encino)

Encino, California, 91316, United States
WR-PRI, LLC (Newport Beach)

Newport Beach, California, 92660, United States
Wake Research/ Tucson Neuroscience Research

Tucson, Arizona, 85710, United States

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