Migraine drug tested for Long-Term safety in 1,000-Person trial

NCT ID NCT07674654

Not yet recruiting Symptom relief Sponsor: Kallyope Inc. Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over time to see if the drug remains safe for repeated use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

elismetrep (K-304)

What this could lead to

If successful, this could confirm that elismetrep is safe for repeated use, offering a new option for treating migraine attacks as they happen.

What could go wrong

This is a safety-focused study, not designed to prove how well the drug works. Side effects may emerge with long-term use, and results may not apply to everyone with migraine.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MIGRAINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AMR Clinical - Kansas City

Kansas City, Missouri, 64114, United States
AMR Clinical - Las Vegas

Las Vegas, Nevada, 89119, United States
AMR Clinical - Lexington

Lexington, Kentucky, 40509, United States
AMR Clinical - Norfolk

Norfolk, Virginia, 23502, United States
AMR Mobile

Mobile, Alabama, 36608, United States
APD Clinical Research

Cypress, Texas, 77372, United States
Access Clinical Trials Inc

Nashville, Tennessee, 37203, United States
Acclaim Clinical Research

San Diego, California, 92120, United States
Advanced Neurosciences Research

Fort Collins, Colorado, 80528, United States
Advanced Research Institute

Ogden, Utah, 84405, United States
Advanced Research Institute-Portland

Portland, Oregon, 97223, United States
Advanced Research Institute-Reno

Reno, Nevada, 89511, United States
Aim Trials, LLC

Plano, Texas, 75093, United States
Albuquerque Clinical Trials

Albuquerque, New Mexico, 87102, United States
Arkansas Clinical Research

Little Rock, Arkansas, 72205, United States
Artemis Institute for Clinical Research

Riverside, California, 92503, United States
Axiom Research, LLC

Colton, California, 92324, United States
Axiom Research, Orange County

Irvine, California, 92604, United States
Boston Clinical Trials - Alcanza

Boston, Massachusetts, 02131, United States
CTI Clinical Research Center

Lexington, Kentucky, 45212, United States
Carolina Research Center, Inc

Shelby, North Carolina, 28150, United States
Cedar Crosse Research Center

Chicago, Illinois, 60607, United States
CenExel Sherman Oaks CA (California Neuroscience Research)

Sherman Oaks, California, 91403, United States
Central New York Clinical Research

Manlius, New York, 13104, United States
Central Research Associates, LLC (CRA) dba Flourish Research

Birmingham, Alabama, 35205, United States
Chase Medical Research, LLC

Waterbury, Connecticut, 06708, United States
Chicago Headache Center & Research Institute

Chicago, Illinois, 60657, United States
Chicago Headache Center & Research Institute

Naperville, Illinois, 60563, United States
CincyScience

West Chester, Ohio, 45069, United States
ClinPoint Trials

Waxahachie, Texas, 75165, United States
Clinical Associates Midwest, LLC

Overland Park, Kansas, 66214, United States
Clinical Investigation Specialists, Inc.

Kenosha, Wisconsin, 53144, United States
Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
Clinical Research Institute

Los Angeles, California, 90048, United States
Clinical Research Institute

Minneapolis, Minnesota, 55402, United States
Clinical Research Philadelphia

Philadelphia, Pennsylvania, 19114, United States
Clinvest Headlands LLC

Springfield, Missouri, 65807, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Collective Medical Research

Overland Park, Kansas, 66212, United States
Crescent City Headache & Neurology Center

Chalmette, Louisiana, 70043, United States
DM Clinical Research

Houston, Texas, 77081, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Gulfport, Mississippi, 39503, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
Dent Neuro Institute, Buffalo

Amherst, New York, 14226, United States
Diablo Clinical Research

Walnut Creek, California, 94598, United States
Downtown L.A. Research Center, Inc.

Los Angeles, California, 90017, United States
Drug Studies America

Marietta, Georgia, 30060, United States
Empire Clinical Research

Pomona, California, 91767, United States
Encompass Clinical Research

Spring Valley, California, 91978, United States
Excel Clinical Research

Las Vegas, Nevada, 89109, United States
Excell Research

Oceanside, California, 92056, United States
Eximia Research - NC, LLC

Raleigh, North Carolina, 27607, United States
Fieve Clinical Research, Inc

New York, New York, 10017, United States
Focus Clinical Research

West Hills, California, 91307, United States
Frontier Clinical Research

Morgantown, West Virginia, 26505, United States
Frontier Clinical Research, LLC

Scottdale, Pennsylvania, 15683, United States
Frontier Clinical Research, LLC

Smithfield, Pennsylvania, 15478, United States
FutureSearch Trials of Dallas, LP

Dallas, Texas, 75251, United States
FutureSearch Trials of Neurology

Austin, Texas, 78731, United States
GMG Clinical Research, LLC dba Radiance Clinical Research

Lampasas, Texas, 76550, United States
Granger Medical Clinic

Riverton, Utah, 84096, United States
Guilford Neurologic Research Partners, LLC

Greensboro, North Carolina, 27405, United States
Headache Wellness Center

Greensboro, North Carolina, 27405, United States
Headlands Research - PharmaSite

Pikesville, Maryland, 21208, United States
Health Research of Hampton Roads, Inc. (HRHR)

Newport News, Virginia, 23606, United States
Healthcare Research Network

Hazelwood, Missouri, 63042, United States
Healthcare Research Network II, LLC

Flossmoor, Illinois, 60447, United States
Heartland Research Associates, LLC - An AMR Company

Wichita, Kansas, 67207, United States
Helios CR, Inc. - Fort Worth

Fort Worth, Texas, 76104, United States
Helios CR, Inc. - Keller

Keller, Texas, 76248, United States
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
Hometown Research

Columbus, Ohio, 43228, United States
Hometown Research

Huber Heights, Ohio, 45424, United States
Hometown Research

Milford, Ohio, 45150, United States
Horizon Clinical Research and Gill Neuroscience

Cypress, Texas, 77429, United States
IMA Clinical Research - Las Vegas

Las Vegas, Nevada, 89102, United States
IMMUNOe Research Centers

Centennial, Colorado, 80112, United States
Integrated Clinical Trials Solution

West Des Moines, Iowa, 50265, United States
J. Lewis Research, Inc. / Foothill Family Clinic

Salt Lake City, Utah, 84109, United States
J. Lewis Research, Inc. / Foothill Family Clinic

Salt Lake City, Utah, 84121, United States
J. Lewis Research, Inc. / Foothill Family Clinic Draper

Draper, Utah, 84020, United States
Kinetic Clinical Research

West Covina, California, 91790, United States
Las Vegas Clinical Trials

North Las Vegas, Nevada, 89030, United States
Leading Edge Research LA, LLC

Encino, California, 91316, United States
Lehigh Center for Clinical Research

Allentown, Pennsylvania, 18103, United States
M3 Wake Research - Mission Mental Health (WR-MMH)

Mission Viejo, California, 92691, United States
MCB Clinical Research Centers

Colorado Springs, Colorado, 80910, United States
MedVadis Research Corporation, LLC

Waltham, Massachusetts, 02451, United States
Michigan Headache Pain & Neurological Institute

Ann Arbor, Michigan, 48104, United States
Minneapolis Clinic of Neurology

Burnsville, Minnesota, 55337, United States
Monroe Biomedical Research (former L-MARC Research Center)

Louisville, Kentucky, 40213, United States
OK Clinical Research, LLC

Edmond, Oklahoma, 73034, United States
OnSite Clinical Solutions

Charlotte, North Carolina, 28277, United States
Pantheon Clinical Research

Bountiful, Utah, 84010, United States
Physicians to Children & Adolescents, PSC (Kentucky Pediatric / Adult Research)

Bardstown, Kentucky, 40004, United States
Preferred Primary Care Physicians, Inc.

Pittsburgh, Pennsylvania, 15236, United States
ProScience Research Group

Culver City, California, 90230, United States
Proven Endpoints

Ridgeland, Mississippi, 39157, United States
Redbird Research

Las Vegas, Nevada, 89119, United States
Relaro Medical Trials, LLC

Dallas, Texas, 75243, United States
Rochester Clinical Research

Rochester, New York, 14609, United States
SPRI Clinical Trials, LLC

Brooklyn, New York, 11235, United States
Seattle Clinical Research Center

Seattle, Washington, 98104, United States
Sleep Care Research Institute d/b/a Clinical Research Atlanta-Stockbridge

Stockbridge, Georgia, 30281, United States
Solace Clinical Research

San Juan, 00907, Puerto Rico
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
Summit Research Network

Portland, Oregon, 97210, United States
Sundance Clinical Research

St Louis, Missouri, 63141, United States
Sunwise Clinical Research

Walnut Creek, California, 94596, United States
Tekton Research

Austin, Texas, 78745, United States
Tekton Research, Inc.

Yukon, Oklahoma, 73099, United States
The Neurology Group

Pomona, California, 91767, United States
TrialSphere

Chandler, Arizona, 85286, United States
True North Neurology

Commack, New York, 11725, United States
Upstate Clinical Research Associates

Williamsville, New York, 14221, United States
Victorium Clinical Research

Houston, Texas, 77024, United States
WR-ClinSearch, LLC

Chattanooga, Tennessee, 37421, United States
Wake Research Las Vegas Rainbow

Las Vegas, Nevada, 89118, United States