Migraine drug tested for Long-Term safety in 1,000-Person trial

NCT ID NCT07674654

Recruiting now Symptom relief Sponsor: Kallyope Inc. Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Aug 13, 2026 · Updated 6 times

Summary

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over time to see if the drug remains safe for repeated use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elismetrep (K-304)
What this could lead to: If successful, this could confirm that elismetrep is safe for repeated use, offering a new option for treating migraine attacks as they happen.
What could go wrong: This is a safety-focused study, not designed to prove how well the drug works. Side effects may emerge with long-term use, and results may not apply to everyone with migraine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MIGRAINE

Contacts and locations

Locations

AMR Clinical - Kansas City
RECRUITING

Kansas City, Missouri, 64114, United States
AMR Clinical - Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89119, United States
AMR Clinical - Lexington
RECRUITING

Lexington, Kentucky, 40509, United States
AMR Clinical - Norfolk
RECRUITING

Norfolk, Virginia, 23502, United States
AMR Mobile
NOT_YET_RECRUITING

Mobile, Alabama, 36608, United States
APD Clinical Research
NOT_YET_RECRUITING

Cypress, Texas, 77372, United States
Access Clinical Trials Inc
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States
Acclaim Clinical Research
NOT_YET_RECRUITING

San Diego, California, 92120, United States
Advanced Neurosciences Research
NOT_YET_RECRUITING

Fort Collins, Colorado, 80528, United States
Advanced Research Institute
NOT_YET_RECRUITING

Ogden, Utah, 84405, United States
Advanced Research Institute-Portland
NOT_YET_RECRUITING

Portland, Oregon, 97223, United States
Advanced Research Institute-Reno
NOT_YET_RECRUITING

Reno, Nevada, 89511, United States
Aim Trials, LLC
NOT_YET_RECRUITING

Plano, Texas, 75093, United States
Albuquerque Clinical Trials
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87102, United States
Arkansas Clinical Research
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205, United States
Artemis Institute for Clinical Research
NOT_YET_RECRUITING

Riverside, California, 92503, United States
Axiom Research, LLC
RECRUITING

Colton, California, 92324, United States
Axiom Research, Orange County
NOT_YET_RECRUITING

Irvine, California, 92604, United States
Boston Clinical Trials - Alcanza
NOT_YET_RECRUITING

Boston, Massachusetts, 02131, United States
CTI Clinical Research Center
NOT_YET_RECRUITING

Lexington, Kentucky, 45212, United States
Carolina Research Center, Inc
NOT_YET_RECRUITING

Shelby, North Carolina, 28150, United States
Cedar Crosse Research Center
NOT_YET_RECRUITING

Chicago, Illinois, 60607, United States
CenExel Sherman Oaks CA (California Neuroscience Research)
RECRUITING

Sherman Oaks, California, 91403, United States
Central New York Clinical Research
NOT_YET_RECRUITING

Manlius, New York, 13104, United States
Central Research Associates, LLC (CRA) dba Flourish Research
RECRUITING

Birmingham, Alabama, 35205, United States
Chase Medical Research, LLC
RECRUITING

Waterbury, Connecticut, 06708, United States
Chicago Headache Center & Research Institute
NOT_YET_RECRUITING

Chicago, Illinois, 60657, United States
Chicago Headache Center & Research Institute
NOT_YET_RECRUITING

Naperville, Illinois, 60563, United States
CincyScience
NOT_YET_RECRUITING

West Chester, Ohio, 45069, United States
ClinPoint Trials
NOT_YET_RECRUITING

Waxahachie, Texas, 75165, United States
Clinical Associates Midwest, LLC
NOT_YET_RECRUITING

Overland Park, Kansas, 66214, United States
Clinical Investigation Specialists, Inc.
NOT_YET_RECRUITING

Kenosha, Wisconsin, 53144, United States
Clinical Research Associates, Inc.
RECRUITING

Nashville, Tennessee, 37203, United States
Clinical Research Institute
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Clinical Research Institute
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55402, United States
Clinical Research Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19114, United States
Clinvest Headlands LLC
NOT_YET_RECRUITING

Springfield, Missouri, 65807, United States
Coastal Carolina Research Center
RECRUITING

North Charleston, South Carolina, 29405, United States
Collective Medical Research
NOT_YET_RECRUITING

Overland Park, Kansas, 66212, United States
Crescent City Headache & Neurology Center
NOT_YET_RECRUITING

Chalmette, Louisiana, 70043, United States
DM Clinical Research
NOT_YET_RECRUITING

Houston, Texas, 77081, United States
DelRicht Research
RECRUITING

Atlanta, Georgia, 30329, United States
DelRicht Research
NOT_YET_RECRUITING

New Orleans, Louisiana, 70115, United States
DelRicht Research
NOT_YET_RECRUITING

Gulfport, Mississippi, 39503, United States
DelRicht Research
RECRUITING

Tulsa, Oklahoma, 74133, United States
Dent Neuro Institute, Buffalo
RECRUITING

Amherst, New York, 14226, United States
Diablo Clinical Research
NOT_YET_RECRUITING

Walnut Creek, California, 94598, United States
Downtown L.A. Research Center, Inc.
NOT_YET_RECRUITING

Los Angeles, California, 90017, United States
Drug Studies America
NOT_YET_RECRUITING

Marietta, Georgia, 30060, United States
Empire Clinical Research
NOT_YET_RECRUITING

Pomona, California, 91767, United States
Encompass Clinical Research
NOT_YET_RECRUITING

Spring Valley, California, 91978, United States
Excel Clinical Research
NOT_YET_RECRUITING

Las Vegas, Nevada, 89109, United States
Excell Research
NOT_YET_RECRUITING

Oceanside, California, 92056, United States
Eximia Research - NC, LLC
NOT_YET_RECRUITING

Raleigh, North Carolina, 27607, United States
Fieve Clinical Research, Inc
RECRUITING

New York, New York, 10017, United States
Focus Clinical Research
RECRUITING

West Hills, California, 91307, United States
Frontier Clinical Research
RECRUITING

Morgantown, West Virginia, 26505, United States
Frontier Clinical Research, LLC
NOT_YET_RECRUITING

Scottdale, Pennsylvania, 15683, United States
Frontier Clinical Research, LLC
NOT_YET_RECRUITING

Smithfield, Pennsylvania, 15478, United States
FutureSearch Trials of Dallas, LP
NOT_YET_RECRUITING

Dallas, Texas, 75251, United States
FutureSearch Trials of Neurology
NOT_YET_RECRUITING

Austin, Texas, 78731, United States
GMG Clinical Research, LLC dba Radiance Clinical Research
NOT_YET_RECRUITING

Lampasas, Texas, 76550, United States
Granger Medical Clinic
NOT_YET_RECRUITING

Riverton, Utah, 84096, United States
Guilford Neurologic Research Partners, LLC
NOT_YET_RECRUITING

Greensboro, North Carolina, 27405, United States
Headache Wellness Center
RECRUITING

Greensboro, North Carolina, 27405, United States
Headlands Research - PharmaSite
RECRUITING

Pikesville, Maryland, 21208, United States
Health Research of Hampton Roads, Inc. (HRHR)
RECRUITING

Newport News, Virginia, 23606, United States
Healthcare Research Network
NOT_YET_RECRUITING

Hazelwood, Missouri, 63042, United States
Healthcare Research Network II, LLC
NOT_YET_RECRUITING

Flossmoor, Illinois, 60447, United States
Heartland Research Associates, LLC - An AMR Company
RECRUITING

Wichita, Kansas, 67207, United States
Hightower Clinical
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73102, United States
Hometown Research
RECRUITING

Columbus, Ohio, 43228, United States
Hometown Research
NOT_YET_RECRUITING

Milford, Ohio, 45150, United States
Horizon Clinical Research and Gill Neuroscience
RECRUITING

Cypress, Texas, 77429, United States
IMA Clinical Research - Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89102, United States
IMMUNOe Research Centers
NOT_YET_RECRUITING

Centennial, Colorado, 80112, United States
Integrated Clinical Trials Solution
NOT_YET_RECRUITING

West Des Moines, Iowa, 50265, United States
J. Lewis Research, Inc. / Foothill Family Clinic
NOT_YET_RECRUITING

Salt Lake City, Utah, 84109, United States
J. Lewis Research, Inc. / Foothill Family Clinic
NOT_YET_RECRUITING

Salt Lake City, Utah, 84121, United States
J. Lewis Research, Inc. / Foothill Family Clinic Draper
NOT_YET_RECRUITING

Draper, Utah, 84020, United States
Kinetic Clinical Research
NOT_YET_RECRUITING

West Covina, California, 91790, United States
Las Vegas Clinical Trials
NOT_YET_RECRUITING

North Las Vegas, Nevada, 89030, United States
Leading Edge Research LA, LLC
NOT_YET_RECRUITING

Encino, California, 91316, United States
Lehigh Center for Clinical Research
RECRUITING

Allentown, Pennsylvania, 18103, United States
M3 Wake Research - Mission Mental Health (WR-MMH)
NOT_YET_RECRUITING

Mission Viejo, California, 92691, United States
MCB Clinical Research Centers
NOT_YET_RECRUITING

Colorado Springs, Colorado, 80910, United States
MedVadis Research Corporation, LLC
RECRUITING

Waltham, Massachusetts, 02451, United States
Michigan Headache Pain & Neurological Institute
RECRUITING

Ann Arbor, Michigan, 48104, United States
Monroe Biomedical Research (former L-MARC Research Center)
NOT_YET_RECRUITING

Louisville, Kentucky, 40213, United States
OK Clinical Research, LLC
NOT_YET_RECRUITING

Edmond, Oklahoma, 73034, United States
OnSite Clinical Solutions
NOT_YET_RECRUITING

Charlotte, North Carolina, 28277, United States
Pantheon Clinical Research
NOT_YET_RECRUITING

Bountiful, Utah, 84010, United States
Physicians to Children & Adolescents, PSC (Kentucky Pediatric / Adult Research)
NOT_YET_RECRUITING

Bardstown, Kentucky, 40004, United States
Preferred Primary Care Physicians, Inc.
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15236, United States
ProScience Research Group
NOT_YET_RECRUITING

Culver City, California, 90230, United States
Proven Endpoints
RECRUITING

Ridgeland, Mississippi, 39157, United States
Redbird Research
NOT_YET_RECRUITING

Las Vegas, Nevada, 89119, United States
Rochester Clinical Research
NOT_YET_RECRUITING

Rochester, New York, 14609, United States
SPRI Clinical Trials, LLC
RECRUITING

Brooklyn, New York, 11235, United States
Seattle Clinical Research Center
NOT_YET_RECRUITING

Seattle, Washington, 98104, United States
Sleep Care Research Institute d/b/a Clinical Research Atlanta-Stockbridge
RECRUITING

Stockbridge, Georgia, 30281, United States
StudyMetrix Research
NOT_YET_RECRUITING

City of Saint Peters, Missouri, 63303, United States
Summit Research Network
NOT_YET_RECRUITING

Portland, Oregon, 97210, United States
Sundance Clinical Research
RECRUITING

St Louis, Missouri, 63141, United States
Sunwise Clinical Research
RECRUITING

Walnut Creek, California, 94596, United States
Tekton Research
NOT_YET_RECRUITING

Austin, Texas, 78745, United States
Tekton Research, Inc.
NOT_YET_RECRUITING

Yukon, Oklahoma, 73099, United States
The Neurology Group
NOT_YET_RECRUITING

Pomona, California, 91767, United States
TrialSphere
NOT_YET_RECRUITING

Chandler, Arizona, 85286, United States
True North Neurology
RECRUITING

Commack, New York, 11725, United States
Upstate Clinical Research Associates
RECRUITING

Williamsville, New York, 14221, United States
Victorium Clinical Research
RECRUITING

Houston, Texas, 77024, United States
WR-ClinSearch, LLC
NOT_YET_RECRUITING

Chattanooga, Tennessee, 37421, United States
Wake Research Las Vegas Rainbow
NOT_YET_RECRUITING

Las Vegas, Nevada, 89118, United States

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