Nerve block shots could ease chronic headaches, trial shows

NCT ID NCT07497646

Completed Symptom relief Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether repeated injections of a numbing drug (bupivacaine) into the back of the head could help people with chronic migraine or chronic tension-type headache. 290 adults received either the drug or a placebo (salt water) injection over three months. The main goal was to see if the treatment reduced the number of headache days per month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine (a numbing medication)
What this could lead to: If it works, this could offer a non-daily treatment option to reduce headache frequency and pain for people with chronic migraine or tension-type headache.
What could go wrong: This is a completed trial, but results may not apply to everyone. The effect may be modest, and injections carry risks like pain, bleeding, or infection at the site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

headache disorder migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE HEADACHE CHRONIC TENSION-TYPE HEADACHE

Contacts and locations

Locations

Sultan Abdulhamid Han Research and Training Hospital

Istanbul, Istanbul, Turkey (Türkiye)

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