CHRONIC MIGRAINE, HEADACHE

This observational study will follow 700 people with migraine who are prescribed anti-CGRP drugs (monoclonal antibodies or gepants) for prevention. Over two years, researchers will track changes in monthly headache days, migraine impact, and disability. The goal is to see how the…

This study tests whether using a higher voltage during a nerve-blocking procedure (pulsed radiofrequency) can better relieve pain in people with chronic migraine who haven't responded to at least two preventive medications. One hundred participants will be randomly assigned to re…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study compares two types of injections for people with chronic migraines or headaches. One targets trigger points in muscles, the other blocks a nerve in the neck. The goal is to see if the simpler trigger point injection works just as well. About 1,000 adults aged 18-65 wil…

This study looks at why some people with chronic migraine don't get better with standard treatments. Researchers want to see if a person's level of suggestibility—how easily they respond to suggestions or expectations—might help predict who could benefit from placebo effects. The…

This study aims to understand how the information given to patients about their treatment affects their response to migraine medication. Researchers will give 60 adults with chronic migraine four different treatment conditions in a random order and measure changes in headache int…