Heart hole migraine sufferers: could blood thinners be the answer?
NCT ID NCT05546320
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the four drugs daily for 12 weeks. The main goal was to see if the drugs cut migraine days or attacks by at least half.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin, metoprolol, clopidogrel, or rivaroxaban
What this could lead to
If it works, this could show that blood thinners or antiplatelet drugs are better than standard migraine meds for people with a PFO, offering a new treatment option.
What could go wrong
This is a completed Phase 2 trial, so results are still early. The drugs may not work better than existing migraine treatments, and blood thinners carry bleeding risks.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated Zunhua People's Hospital of North China University of Science and Technology
Zunhua, Hebei, China
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
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Central China Fuwai Hospital of Zhengzhou University
Zhengzhou, Henan, China
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Clinical Medical College and Affiliated Hospital of Chengdu University
Chengdu, Sichuan, China
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Dalian Municipal Central Hospital
Dalian, Liaoning, China
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Dalian University Affiliated Zhongshan Hospital
Dalian, Liaoning, China
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Daqing Longnan Hospital
Daqing, Heilongjiang, China
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First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
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Fuwai Cardiovascular Hospital of Yunnan Province
Kunming, Yunnan, China
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Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen Hospital
Shenzhen, Guangdong, China
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Gansu Provincial Hospital
Lanzhou, Gansu, China
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
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Guizhou Provincial People's Hospital
Guiyang, Guizhou, China
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Hebei General Hospital
Shijiazhuang, Hebei, China
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Jiangxi Provincial People's Hospital Affiliated to Nanchang University
Nanchang, Jiangxi, China
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Nanyang Central Hospital
Nanyang, Henan, China
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National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
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People's Hospital of Ningxia Hui Autonomous Region Affiliated to Ningxia Medical University
Yinchuan, Ningxia, China
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Qingdao Fuwai Cardiovascular Hospital
Qingdao, Shandong, China
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Shangqiu First People's Hospital
Shangqiu, Henan, China
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Suzhou Hospital of Anhui Medical University
Suzhou, Anhui, China
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The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
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The First Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, China
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The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
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The First Affiliated Hospital of USTC
Hefei, Anhui, China
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The First Affiliated Hospital, Guangxi Medical University
Nanning, Guangxi, China
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The Fourth People's Hospital of Shenyang
Shenyang, Liaoning, China
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The Second Affiliated Hospital of Lanzhou University
Lanzhou, Gansu, China
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The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
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The Second Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
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The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
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The Second Hospital, Cheeloo College of Medicine, Shandong University
Jinan, Shandong, China
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The Seventh Affiliated Hospital of Sun Yat-sen University
Shenzhen, Guangdong, China
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West China Hospital of Sichuan University
Chengdu, Sichuan, China
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Wuhan Asia Heart Hospital
Wuhan, Hubei, China
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Xiangyang Central Hospital
Xiangyang, Hubei, China
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Xingtai People's Hospital
Xingtai, Hebei, China
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Zhengzhou Central Hospital Affiliated to Zhengzhou University
Zhengzhou, Henan, China
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Zibo Central Hospital Affiliated to Binzhou Medical College
Zibo, Shandong, China