Could a gentle zap to the neck ease long COVID fatigue?

NCT ID NCT05445427

Completed Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is to see if this simple, drug-free approach can improve daily life for those with lingering COVID symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-invasive vagus nerve stimulator
What this could lead to: If it works, this could point toward a simple, drug-free way to manage lingering fatigue and headaches after COVID-19.
What could go wrong: This is a very small pilot study with only 18 people, so results may not apply widely. The device may not work better than a placebo, and benefits could be minor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fatigue Headache headache disorder long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FATIGUE HEADACHE POST-COVID SYNDROME

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.