Long COVID-19

This study tests a comprehensive, remotely delivered care program for people aged 40 and older with Long COVID who have ongoing heart or lung symptoms like fatigue, shortness of breath, or chest pain. The program includes medication review, mental health support, telehealth coach…

This study tests a new supplement called PNMR in 82 adults with long COVID. Participants either take PNMR plus standard care or standard care alone for 6 weeks. The main goal is to see if PNMR helps people walk farther in a 6-minute test. All participants also get diet and lifest…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests whether a low dose of sirolimus (rapamycin), a drug that calms the immune system, can help adults with Long COVID feel better. Eighty participants will take either sirolimus or a placebo pill once a week for 12 weeks. The main goal is to see if the drug improves …

This study tests the safety of a drug called Anktiva in 40 adults with Long COVID—persistent symptoms after a COVID-19 infection. Participants receive the drug as a shot, and researchers monitor for side effects and changes in symptoms. The goal is to see if Anktiva is safe enoug…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This Phase 2 trial tests the safety of a drug called Anktiva (N-803) in 20 adults with Long COVID. Participants get up to two shots and are monitored for side effects and changes in immune cells and quality of life. The goal is to see if the drug is safe enough to study further f…

This expanded access program offers REGENECYTE, a human umbilical cord blood infusion, to adults with Long COVID who cannot join other clinical trials. Participants must have a recent negative COVID-19 test and provide consent. The goal is to provide potential treatment access wh…

This phase 2 trial tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID who also have POTS (a condition causing rapid heart rate upon standing). The study will enroll 50 participants and randomly assign them to receive either 2-HOBA o…

This study tests if the drug anakinra can help people with long COVID who have ongoing breathing issues and signs of an overactive immune system. About 182 adults will receive either anakinra or a placebo for up to 8 weeks. The goal is to see if the drug improves lung function, r…

Some people with long COVID have harmful antibodies that may be attacking their own bodies, causing severe fatigue and other symptoms. This study tests a treatment called immunoadsorption, which filters the blood to remove those antibodies. About 70 participants will receive eith…

This study tests two drugs—pyridostigmine (Mestinon) and low-dose naltrexone (LDN)—alone or together in 160 adults with ME/CFS or Long COVID who also have orthostatic intolerance (difficulty standing). Over 3 months, participants take gradually increasing doses and complete exerc…

This study is testing whether a dietary supplement called MitoQ, combined with exercise rehabilitation, can improve blood vessel function in older adults (50+) suffering from long-COVID. The trial will enroll 300 participants, including both long-COVID patients and those who have…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study tests whether following a healthy US-style diet rich in anti-inflammatory foods can reduce fatigue and improve muscle and physical function in adults aged 50 and older with long COVID. Over 16 weeks, participants are randomly assigned to either receive personalized die…

This study tests whether a program of water-based exercise followed by memory training can help Veterans with long COVID symptoms like brain fog and fatigue. About 50 people will take part over 8 months. The goal is to see if the program is safe, doable, and helpful.

This study tests whether fluvoxamine, an antidepressant, can reduce severe fatigue and other symptoms in people with post-COVID. 160 adults aged 18-70 with long-lasting fatigue after COVID will receive either the drug or a placebo for 12 weeks. The goal is to see if it improves e…

This study tests whether taking taurine—a natural amino acid—for 12 weeks can improve blood vessel function and reduce dizziness when standing up in people with Long COVID. Researchers will measure blood flow, heart rate, and brain blood flow in 30 participants before and after s…

This Mayo Clinic pilot study tests whether breathing controlled levels of oxygen or carbon dioxide can help people with Long COVID brain fog. 45 participants will try short sessions of these gas mixtures and report changes in brain fog, fatigue, and blood flow. The goal is to see…

This study tests whether taking taurine supplements can reduce brain fog, memory problems, and fatigue in people with Long COVID. About 300 adults who had COVID-19 at least 3 months ago will take taurine or a placebo for 3 months. Researchers will measure changes in fatigue and t…

This study is testing a mind-body program called DNRS for people with ME/CFS (chronic fatigue syndrome) who may also have Long COVID. The program uses brain retraining to help calm overactive nerves and improve symptoms like fatigue, pain, and mood. Researchers will track quality…

This study looks at whether a large IV bag of saline (salt water) can improve thinking problems like brain fog in people with Long COVID or a condition called POTS. About 100 adults will receive either a full or tiny dose of saline to compare effects on reaction time and memory. …

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This phase II trial tests whether the drug sonlicromanol can reduce fatigue in 80 people with long COVID who experience post-exertional malaise (worsening symptoms after activity). Participants take the drug or a placebo twice daily for 13 weeks, and researchers measure changes i…

This Phase 2 trial tests whether the drug plitidepsin can improve overall health in 90 adults with moderate-to-severe long COVID symptoms. Participants receive either plitidepsin or a placebo intravenously over four 3-day cycles, with a 90-day follow-up. The study is double-blind…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This Phase 3 trial tests two repurposed drugs—upadacitinib and pirfenidone—against a placebo in 348 adults with Long COVID. Participants from six countries will take the drugs for three months to see if they ease symptoms like fatigue, breathing trouble, memory issues, muscle pai…

This study tests a drug called DAOIB in 40 people with Long COVID who have memory and thinking problems (brain fog). Everyone gets the drug for 24 weeks, and researchers check their thinking skills, mood, and quality of life every 8 weeks. The goal is to see if DAOIB can help imp…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to help children ages 11-18 with post-concussion syndrome or long COVID symptoms like pain, nausea, and balance problems. Participants must have had symptoms for at least 3 months. The goal i…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study tests whether two HIV antiviral drugs, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may cause ongoing symptoms. 90 participants will take one of the drugs or a placebo daily for 90 days, and their health …

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study tests if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can ease lingering symptoms like brain fog and fatigue in people with Long COVID. Researchers will enroll 120 adults who had COVID-19 at least 3 months ago. The goal is to see if this t…

This study tests whether a 12-week exercise program delivered through a smartphone app can improve physical function and heart health in people with long COVID. Sixty adults with ongoing fatigue or shortness of breath after a COVID-19 infection will be randomly assigned to either…

This study tests whether a mind-body intervention, including educational sessions and personalized support, can reduce long COVID symptoms like pain, fatigue, and dizziness. Researchers will compare it to usual care and another mind-body program in 180 adults. The goal is to see …

This study tests whether a single injection near a nerve cluster in the neck (stellate ganglion block) can reduce long COVID symptoms like fatigue, brain fog, and trouble breathing. About 40 adults with persistent symptoms will receive either the active injection or a placebo. Re…

This study tests whether Shengmai liquid, a traditional Chinese herbal drink, can reduce fatigue in people with Long COVID. One hundred adults aged 18-75 will take either the liquid or a placebo daily for 8 weeks. Researchers will measure changes in fatigue, mood, and sleep quali…

This study looks at whether special breathing exercises combined with core-strengthening moves can help people with Post-COVID syndrome. About 40 adults aged 18-65 will do either core exercises alone or core plus breathing training for 8 weeks. Researchers will measure changes in…

This study tests whether a device that sends gentle sound pulses to the brain can reduce fatigue, brain fog, and mood problems in people with long COVID. 102 adults who have had COVID-19 at least 12 months ago will receive either real or fake (sham) treatment over five sessions. …

This study tests a gentle brain stimulation technique called rTMS to see if it can reduce severe fatigue and concentration problems in people with long COVID. Researchers will give 66 adults either real or fake (placebo) stimulation over six weeks. The goal is to find a safe, non…

This pilot study will test whether acupuncture, with or without Chinese herbal medicine, is a practical and helpful treatment for long COVID. Ten adults with long COVID will receive 16 acupuncture sessions over 8 weeks; half will also take herbal supplements. The main goal is to …

This study tests if cold water therapy (Kneipp hydrotherapy) can improve quality of life for people with Long COVID. Thirty adults with a Post-COVID diagnosis will either receive the cold water treatment or continue usual care. Researchers will measure changes in fatigue, sleep, …

This study looks at whether a supervised exercise program (cardiac rehab) can improve quality of life and physical ability in people with Long COVID. Researchers will also study how the heart and lungs work in these patients. The study needs 30 adults who have had Long COVID symp…

This pilot study from Massachusetts General Hospital is testing whether whole body hyperthermia (like a sauna) can reduce Long COVID symptoms, especially fatigue. Researchers will enroll 21 adults aged 18-65 who have had COVID-19 at least 12 weeks prior. Participants will lie in …

This study tests whether at-home lower-body heat therapy can help older adults (ages 50-90) with long COVID improve their walking ability and overall physical function. Participants will use heat therapy at home, and researchers will measure changes in walking distance, physical …

This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different tre…

This study tests whether a 60-second ultrasound pulse to the brain can improve thinking and memory in people with long COVID brain fog. Forty participants will receive either real or fake (sham) stimulation, and their cognitive performance will be measured before and after. The g…

This study looks for specific signs of long COVID in the brain and blood. Researchers will compare people with and without long COVID symptoms using brain scans and blood tests. The goal is to find objective markers that could help doctors diagnose long COVID more reliably.

This study is testing whether a radioactive tracer called 11C-PS13 can detect brain inflammation in people who have long-term neurological symptoms after COVID-19. Researchers will compare PET scans from 60 adults (both healthy volunteers and those with long COVID) to see if the …

This study looks at long-term health problems in 400 adults who had COVID-19 and are now preparing for surgery. Researchers will ask about ongoing symptoms like breathing issues, heart problems, and fatigue. No new treatments are given; the goal is to understand how past COVID-19…

This study aims to find out whether people with long COVID still have inactive remnants of the SARS-CoV-2 virus in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long COVID symptoms and some without. The goal is to…

This study uses a special PET scan to look for inflammation in the brains of people with long COVID who have neurological symptoms like brain fog or headaches. Researchers will compare these scans with those from healthy volunteers to better understand how the virus may affect th…

This study uses a special full-body PET/CT scan to look for signs of immune system activity in people with Long COVID. Researchers will compare scans from 51 participants with and without Long COVID to see where the body might be inflamed. The goal is to better understand what ca…

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, w…

This study collects blood and nasal secretions from up to 2,000 people with COVID-19 to learn why some get very sick while others recover easily. Researchers will also track long-term symptoms like fatigue and brain fog. No treatments are tested—the goal is to gather data to guid…

This study aims to understand why some people continue to have symptoms like shortness of breath and fatigue long after a severe COVID-19 infection. Researchers will follow 67 adults for up to 12 months, using scans, blood tests, and other measures to look for clues in the lungs …

This study is recruiting 136 veterans to understand why Long-COVID causes walking and balance issues. Researchers will test thinking, vision, muscle strength, and movement under different conditions. The goal is to create better ways to diagnose and treat these problems, helping …

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study looks at how different sleep-wake patterns (called circadian rhythms) affect breathing strength, physical activity, and eating habits in people with Post-COVID syndrome. Researchers will study 50 adults aged 18-65 who have been diagnosed with long COVID. The goal is to…

This study follows 650 adults in Quebec to learn about the short- and long-term health problems caused by COVID-19, including damage to the heart, lungs, kidneys, and other organs. Participants include people who had mild, moderate, or severe COVID-19, as well as those who never …

This study looks at why some veterans experience ongoing brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these symptoms and identify target…

This study follows 400 adults with long COVID for four years to understand how the condition changes over time. Researchers will look at blood markers, blood vessel health, and fatigue levels. The goal is to find better ways to diagnose and manage long COVID in the future.

This study follows 1,590 adults who have had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the range of recovery experiences and identify factors that lead to p…

This study aims to understand how changes in gut bacteria (dysbiosis) affect the immune system and gut health in people with long COVID. Researchers will collect stool and blood samples from 400 adults—half with long COVID symptoms and half without. The goal is to find links betw…

This observational study will enroll 200 people in Navarre who have had COVID-19 and still have symptoms lasting more than 3 months. Researchers will collect information on demographics, health history, and ongoing symptoms to better understand long COVID. The goal is to describe…

This study uses PET and MRI scans to look at brain changes in people who developed depression within three months after a mild or moderate COVID-19 infection. Researchers will compare brain scans of 90 participants to see if key brain chemicals are altered. The goal is to better …

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study looks at 150 adults with long-COVID to group them by their symptoms and link those groups to lab results. The goal is to find patterns that could help doctors predict outcomes and discover new treatments. Participants will have their health data and blood samples analy…

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study is testing whether a detailed heart MRI (called T1 mapping) can better predict who will develop heart disease, heart failure, or long COVID complications. Researchers will scan 6000 adults without known heart disease and follow them over time. The goal is to see if sub…

This study tests a training program for VA doctors to improve how they care for Veterans with Long-COVID. The training focuses on listening to patients, building a shared understanding of the condition, and creating a personalized care plan. About 348 Veterans and their doctors w…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study looks at why people with Long COVID (PASC) feel so tired. Researchers will use brain scans and effort-based tasks to compare 200 adults with and without Long COVID. The goal is to find brain changes that cause fatigue, which could lead to better treatments and rehab.

This pilot study tests whether an intensified schedule of repetitive transcranial magnetic stimulation (iTBS) — six sessions a day for five days — works better than the standard one-session-a-day for six weeks in people with depression and Post-COVID condition. Researchers will m…