Could a weekend of brain zaps ease depression and long COVID?

NCT ID NCT07197138

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether an intensified schedule of repetitive transcranial magnetic stimulation (iTBS) — six sessions a day for five days — works better than the standard one-session-a-day for six weeks in people with depression and Post-COVID condition. Researchers will measure changes in blood markers of inflammation and depression symptoms in 42 participants. The goal is to gather early evidence for larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

repetitive transcranial magnetic stimulation (rTMS) using intermittent theta-burst stimulation (iTBS)

What this could lead to

If it works, this could point toward a faster treatment schedule for depression and Post-COVID fatigue by reducing brain inflammation.

What could go wrong

This is a very small pilot study (42 people) with no placebo group, so results may not be conclusive or apply to everyone. The intensified schedule may cause more discomfort or side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

depressive disorder long COVID-19 major depressive disorder Neuroinflammatory Diseases post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • Max-Planck-Institute of Psychiatry

    RECRUITING

    Munich, Bavaria, 80804, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••