Could breathing different gases clear long COVID brain fog?
NCT ID NCT06614309
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Mayo Clinic pilot study tests whether breathing controlled levels of oxygen or carbon dioxide can help people with Long COVID brain fog. 45 participants will try short sessions of these gas mixtures and report changes in brain fog, fatigue, and blood flow. The goal is to see if this non-invasive approach is worth studying further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- breathing controlled levels of oxygen and carbon dioxide
- What this could lead to
- If it works, this could point toward a simple, non-invasive way to reduce brain fog and fatigue in people with Long COVID.
- What could go wrong
- This is a very early pilot study with only 45 people. The treatment is experimental and may not improve symptoms. Some people may feel discomfort from the gas mixtures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic in Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Five years on: how does long COVID evolve?
- Could exercise retrain the heart in long COVID?
- Can brain games and gentle currents lift long COVID brain fog?
- Can brain training zap long COVID brain fog?
- Ear device zaps vagus nerve in bid to quiet long COVID fatigue and brain fog
- Smartphone therapy could ease long COVID's mental toll