Can brain games and gentle currents lift long COVID brain fog?

NCT ID NCT05965739

Completed Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether a computer-based brain training program, alone or combined with other techniques, can improve thinking and memory in people with long COVID. Participants will be randomly assigned to different training approaches, including a placebo-like activity. The goal is to see if these interventions can ease the cognitive difficulties that often follow a COVID-19 infection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BrainHQ cognitive training, with or without PASC CoRE or transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could point toward accessible, non-drug ways to ease the memory and thinking problems that many people with long COVID face.
What could go wrong: This is an early-stage platform trial, so results may not be conclusive. The interventions may not work for everyone, and tDCS carries minor risks like skin irritation or discomfort.

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Conditions

The condition(s) this trial relates to.

long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID LONG COVID-19 LONG COVID19

Contacts and locations

Locations

All sites listed under NCT05965752

Durham, North Carolina, 27710, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.