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Ear device zaps vagus nerve in bid to quiet long COVID fatigue and brain fog

NCT ID NCT06585254

Ongoing Symptom relief Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether a small device that stimulates the vagus nerve through the ear can improve quality of life for people with long COVID who also meet the criteria for ME/CFS (chronic fatigue syndrome). Participants will use the device daily for six weeks, and researchers will compare two different stimulation settings to see which one works better. The goal is to reduce fatigue, pain, post-exertional malaise, and brain fog.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a device that gently stimulates the vagus nerve through the ear (transcutaneous vagus nerve stimulation)
What this could lead to
If it works, this could point toward a drug-free way to manage debilitating symptoms like fatigue, pain, and brain fog in long COVID and ME/CFS.
What could go wrong
This is a small, early-stage trial comparing two stimulation settings, not a proven treatment. The device may not help, and some people may find the stimulation uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

long COVID-19 myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC FATIGUE SYNDROME LONG COVID

Contacts and locations

Locations

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

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Other studies related to the condition(s) this trial covers.