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Digital fatigue detectives: can wearables unmask the hidden toll of MS and long COVID?

NCT ID NCT07783074

Knowledge-focused Sponsor: Liliana Barrios Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study explores whether smartphone apps and wearable devices can objectively measure fatigue in people with multiple sclerosis (MS) and long COVID, compared to healthy volunteers. Fatigue is often reported through subjective questionnaires, which can be biased. Participants will wear a smartwatch and an armband monitor continuously for two months, and use a smartphone app to complete daily tasks and surveys. The goal is to see if these digital tools are feasible and accurate for tracking fatigue in real time, which could improve how fatigue is assessed in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Smartphone app (FIDO) and wearable devices (smartwatch and armband activity monitor) for digital fatigue monitoring
What this could lead to
If successful, this could lead to more objective, real-time fatigue tracking tools for MS and long COVID, improving patient care and clinical trials.
What could go wrong
This is an exploratory feasibility study, not a treatment trial. It may not prove that digital measures are reliable or acceptable to all patients, and results may not generalize beyond the study's specific devices and app.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 122 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Multiple sclerosis participants will be recruited through Bellevue Medical Group (BMG) and NeuroPraxis Zürich during routine clinical visits. External patients may also participate if they have a diagnosis from a recognized medical institution. Long COVID participants will be recruited from Klinik Lengg during routine clinical visits. External patients may also participate if they have a diagnosis from a recognized medical institution. Healthy controls will be recruited from the general community in Zurich. Recruitment across all groups will use physical and digital study flyers; the Long Covid Switzerland association will additionally support flyer distribution. Interested individuals may contact the UZH study team by email or phone to learn about study aims and eligibility; those willing and eligible will be directed to a study site.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Multiple Sclerosis or Long COVID * Confirmed diagnosis of MS (by neurologist) or Long COVID (by medical doctor). * Smartphone ownership. * Provide written informed consent. * Fluent in German or English. Inclusion Criteria Healthy: * Smartphone ownership. * Provide written informed consent. * Fluent in German or English. Exclusion Criteria: * Concomitant medication affecting fatigue or ANS such as antidepressants prescribed or adjusted 1 month before the initial visit. * Unable to provide informed consent. * Unwilling or unable to comply with the study protocol. * Pregnancy or lactation. * For controls: Diagnosis of any chronic disorders or diseases that may affect fatigue or ANS. * For MS: Additional comorbidities that may affect fatigue or ANS such as autoimmune disease and cardiovascular disease. * For long COVID: Additional comorbidities diagnosed prior to the first acute COVID-19 infection that may affect fatigue or ANS such as autoimmune disease and cardiovascular disease.

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Conditions

The condition(s) this trial relates to.

Fatigue long COVID-19 multiple sclerosis Patient Compliance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Long COVID Multiple sclerosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    6 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bellevue Medical Group - Neurozentrum Seefeld

    RECRUITING

    Zurich, Canton of Zurich, 8008, Switzerland

  • Bellevue Medical Group - Neurozentrum Sternen / Neurozentrum Bellevue

    RECRUITING

    Zurich, Canton of Zurich, 8001, Switzerland

  • Klinik Lengg AG

    RECRUITING

    Zurich, Canton of Zurich, 8008, Switzerland

    Contact Email: •••••@•••••

  • NeuroPraxis Zürich GmbH

    RECRUITING

    Zurich, Canton of Zurich, 8006, Switzerland

  • Neurozentrum Basel Messeturm

    RECRUITING

    Basel, Basel, 4058, Switzerland

  • University of Zurich

    RECRUITING

    Zurich, Canton of Zurich, 8001, Switzerland

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