LONG COVID

This study offers expanded access to an experimental treatment called REGENECYTE, made from human umbilical cord blood, for people with long COVID. Participants must be 18 or older, have a confirmed post-COVID condition, and test negative for active COVID-19. The goal is to see i…

This study tests whether two medications—pyridostigmine and low-dose naltrexone—can improve daily function and energy in people with ME/CFS or Long COVID who also have trouble standing (orthostatic intolerance). 160 adults aged 18-70 will be randomly assigned to one of four group…

This study tests a drug called anakinra (already used for arthritis) in 182 adults with long COVID who have ongoing breathing issues and signs of an overactive immune system. Participants receive either anakinra or a placebo for 4 to 8 weeks. The goal is to see if the drug can im…

Some people with long COVID have ongoing symptoms like severe fatigue, possibly because their immune system attacks their own body. This study tests a treatment called immunoadsorption, which filters the blood to remove harmful antibodies. About 70 adults with long COVID and thes…

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, physical function, and quality of life in people with long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This Mayo Clinic pilot study tests whether controlled changes in oxygen and carbon dioxide levels can help people with long COVID brain fog. The study will measure blood flow in the brain, heart rate, and brain fog symptoms in 45 adults. Participants must speak English and have a…

This study compares two types of brain training programs for 30 adults with long COVID who have mild to moderate brain fog. One program uses computer games and real-life tasks to improve thinking speed and work skills, while the other focuses on relaxation and healthy habits. Bot…

This study tests whether taking taurine, a natural supplement, can improve thinking, memory, and energy in people with Long COVID. Researchers will enroll 300 adults who have had COVID-19 and still struggle with brain fog or fatigue. Participants take taurine or a placebo for thr…

This study tests if at-home lower-body heat therapy can improve walking ability and overall health in people aged 50-90 with long COVID. Participants will use heat sessions to see if it eases fatigue and physical decline. The goal is to find a simple, accessible way to help those…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—to help people with long COVID who have lost or distorted their sense of smell. About 145 adults who had normal smell before COVID and are at least one month past infection will participa…

This early-stage study is testing a supplement called lumbrokinase in 120 adults with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. The goal is to see if it can improve overall health and quality of life. Participants take the enzyme and report their well-being usi…

This study is testing a device called Hi-OxSR that lets people briefly rebreathe carbon dioxide (CO2) to see if it can reduce brain fog and fatigue caused by Long COVID. The researchers believe CO2 may calm the immune system and reduce inflammation. About 120 adults with lingerin…

This study tests whether mind-body practices can reduce symptoms like pain, fatigue, and dizziness in people with Long COVID. About 180 adults will be randomly assigned to a mind-body program, a different mind-body approach, or usual care. The goal is to see if these techniques i…

This small pilot study is testing whether acupuncture, with or without Chinese herbal supplements, can help people with long COVID feel better. Ten adults with confirmed past COVID-19 and ongoing symptoms will receive 16 acupuncture sessions over 8 weeks. The goal is to see if th…

This study tests the safety of a drug called NAI (Anktiva) in 40 adults with Long COVID—symptoms that last after a COVID-19 infection is over. Researchers will monitor side effects and changes in lab results. The goal is to see if the drug is safe enough for further testing.

This study tests whether a stellate ganglion block—a numbing injection near nerves in the neck—can improve long COVID symptoms like fatigue, brain fog, and trouble breathing. About 40 adults with persistent symptoms for at least 3 months will receive either the real injection or …

This study is testing whether hyperbaric oxygen therapy (HBOT) can help people with Long COVID who struggle with brain fog, fatigue, and other lingering symptoms. HBOT delivers high levels of oxygen to the body, which may reduce inflammation and improve blood vessel function. The…

This study tests two existing medications (upadacitinib and pirfenidone) to see if they can reduce Long COVID symptoms like fatigue, breathing trouble, brain fog, and pain. About 348 adults from six countries who have had COVID-19 and symptoms for at least three months will take …

This study tests whether two HIV medications can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may play a role. 90 participants will take either Truvada, Selzentry, or a placebo daily for 90 days, and their health will be tracked using a stand…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for long COVID symptoms like severe fatigue and trouble concentrating. Researchers will give 66 adults either real or fake rTMS sessions over six weeks to see if it improves fatigue and thinki…

This study tests whether whole body hyperthermia, a sauna-like procedure, can reduce Long COVID symptoms, especially fatigue. Researchers at Massachusetts General Hospital will enroll 21 adults aged 18-65 who have had COVID-19 and now suffer from ongoing symptoms. Participants wi…

This study tests whether a structured 8-week program of physical and cognitive exercises can improve daily function, thinking skills, and quality of life in adults with Long COVID and chronic conditions like high blood pressure or diabetes. About 374 participants will be randomly…

This study tests whether plitidepsin, a drug given by IV, can improve overall health in adults with moderate to severe long COVID symptoms. About 90 people will receive either the drug or a placebo over four treatment cycles (one every two weeks), then be followed for 90 days. Th…

This study tests a drug called Anktiva in 20 adults with Long COVID to see if it is safe and tolerable. Participants receive up to two doses and are monitored for side effects and symptom changes. The goal is to find a new way to ease the lasting symptoms of COVID-19.

This study tests whether a gentle ultrasound pulse to a specific brain area can improve thinking problems in people with long COVID brain fog. Researchers will compare active ultrasound to a sham (fake) treatment in 40 adults who have had brain fog for at least 4 weeks after COVI…

This study tests a drug called DAOIB to see if it can help with memory and thinking problems caused by long COVID. About 40 adults with long COVID and brain fog will take the drug for 24 weeks. Researchers will check their thinking skills, mood, and quality of life every 8 weeks.

This study is testing whether an oral medication called bezisterim (NE3107) can help ease common Long COVID symptoms like brain fog, memory problems, and fatigue. About 208 adults with Long COVID will take either the drug or a placebo pill twice daily for 12 weeks. Researchers wi…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will measure immune cells and inflammati…

This study looks at 400 adults who had COVID-19 and are now preparing for surgery. Researchers want to find out how often long-term symptoms like breathing problems, heart issues, or tiredness still affect them. By asking questions and checking medical records, they hope to learn…

This observational study looks at brain changes in people who developed major depression within 3 months after a mild or moderate COVID-19 infection. Researchers will use special PET scans to measure two brain chemicals in 90 adults aged 18 to 75. The goal is to understand the bi…

This study looks at whether special rehabilitation therapies can help older Veterans recover from Long-COVID by improving blood vessel function. It involves 300 participants aged 50 and older who are 3-12 months past their COVID-19 diagnosis. The goal is to find safe, effective w…

This study looks at why some veterans experience lasting mental health issues and memory problems, often called 'brain fog,' after COVID-19. Researchers will track 200 veterans over time, using questionnaires and online tests to measure thinking skills and mood. They will also an…

This study looks at how tiny structures inside cells called mitochondria use oxygen to make energy. Researchers want to see if this process is different in people with long COVID compared to those who fully recovered. About 54 adults will wear activity trackers, answer surveys, a…

This study is for adults aged 18 to 70 who have long COVID with brain-related symptoms like headaches, memory problems, or depression. Researchers will use a special radioactive tracer and PET scans to see if there is inflammation in the brain. The goal is to better understand wh…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study follows 650 adults in Quebec to learn about the short- and long-term health problems caused by COVID-19, including damage to the heart, lungs, kidneys, and other organs. Researchers will compare people who had mild, severe, or no COVID-19, as well as those with flu-lik…

This study looks at why some people, mostly women, develop a fast heart rate and dizziness months after a COVID-19 infection. Researchers will measure immune system activity and nerve function in 60 participants to find possible causes. The goal is to better understand this condi…