LONG COVID

This study is testing if a medication called baricitinib can help people suffering from Long COVID. It will involve 550 adults who have had symptoms like brain fog, fatigue, and shortness of breath for at least six months after a COVID-19 infection. Participants will be randomly …

This trial is testing if a drug called anakinra can help people with long COVID who have ongoing breathing problems and signs of an overactive immune system. About 182 participants will be randomly assigned to receive either anakinra or a placebo for 4 to 8 weeks. The main goal i…

This program provides expanded access to an experimental treatment for people suffering from Long COVID. It will give up to 30 adults an infusion of cells from donated umbilical cord blood, called REGENECYTE, to see if it can help control their ongoing symptoms like severe fatigu…

This study is testing whether a drug called Anktiva is safe for people with Long COVID—persistent symptoms that continue after the initial infection has cleared. The trial will enroll 40 adults who have had bothersome Long COVID symptoms for at least 60 days. Researchers will clo…

This study is testing whether two existing HIV antiviral medications can help reduce the burden of symptoms for people living with Long Covid. Researchers will compare the drugs, taken daily for 90 days, against a placebo pill in 90 adult participants. The main goal is to see if …

This study aims to help older Veterans who are struggling with Long-COVID symptoms like fatigue and weakness. Researchers are testing whether a program of exercise, with or without a special antioxidant supplement (Mito-Q), can improve blood vessel health and speed up recovery. T…

This early-stage study is testing whether a supplement called lumbrokinase can improve overall health and reduce symptoms for people with three debilitating long-term conditions: Long Covid, chronic Lyme disease, and ME/CFS (chronic fatigue syndrome). The trial will enroll 120 ad…

This study is testing a treatment called immunoadsorption for people with long COVID who have harmful antibodies in their blood. The treatment filters the blood to remove these antibodies. About 70 participants will be randomly assigned to receive either the real blood-filtering …

This Mayo Clinic study is testing if breathing controlled mixtures of air with slightly less oxygen and more carbon dioxide can help people with Long COVID who have 'brain fog.' Researchers will measure changes in brain blood flow, heart rate, and cognitive test scores to see if …

This study is testing if a drug called DAOIB can help improve thinking, memory, and mood problems in people with long COVID. All 40 participants will take DAOIB for 24 weeks and have their symptoms checked regularly. The goal is to see if the treatment can ease the cognitive symp…

This study is testing whether mind-body practices like meditation can help reduce common Long COVID symptoms such as pain, fatigue, and shortness of breath. Researchers will compare two different mind-body programs against usual medical care in 180 adults who have had symptoms fo…

This study is testing whether two existing medications, pyridostigmine and low-dose naltrexone, can help improve symptoms and function for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. It will involve 160 adults who have these conditions …

This study is testing whether a gentle, non-invasive ultrasound treatment aimed at a specific brain area can improve thinking and memory problems in people with long COVID 'brain fog'. Researchers in Beijing will give 40 participants either the real ultrasound treatment or a sham…

This study is testing if a single injection near nerves in the neck, called a stellate ganglion block, can help reduce persistent symptoms of long COVID like severe fatigue, brain fog, and shortness of breath. About 40 adults with long COVID will be randomly assigned to receive e…

This study is testing whether breathing pure oxygen in a special pressurized chamber (hyperbaric oxygen therapy) can help improve thinking problems like 'brain fog' in people with Long COVID. Researchers will enroll 120 adults who have had COVID-19 symptoms for at least 3 months …

This small pilot study is testing whether acupuncture, with or without Chinese herbal supplements, is a practical and helpful approach for people suffering from long COVID. Ten adults with long-term symptoms like fatigue, brain fog, or pain after a COVID-19 infection will receive…

This study is exploring whether light, self-paced swimming might be a more tolerable way for people with conditions like ME/CFS and Long COVID to move their bodies. It focuses on how being in water might help reduce symptoms like extreme fatigue and post-exertional malaise. Resea…

This study is testing whether a special breathing device called Hi-OxSR can help reduce symptoms of Long COVID, especially brain fog and fatigue. The device works by having participants re-breathe a small amount of carbon dioxide, which may calm an overactive immune system. Resea…

This study is testing whether taking taurine, a common dietary supplement, can help reduce the brain fog and severe fatigue experienced by people with Long COVID. Researchers at the University of Alberta are recruiting 300 adults who have had lingering COVID symptoms for at least…

This study is testing whether an oral medication called bezisterim (NE3107) can help improve the persistent 'brain fog' and fatigue experienced by many people with Long COVID. Researchers will compare the drug to a placebo (a dummy pill) over 12 weeks in 208 adults. The main goal…

This small pilot study is testing whether a sauna-like whole-body heat treatment can help reduce symptoms of Long COVID, especially fatigue. Researchers will enroll 21 people with Long COVID to test the treatment's feasibility and see if it improves fatigue, sleep, and inflammati…

This large, international study is testing if two medications already used for other conditions can help people suffering from Long COVID. About 348 adults with Long COVID symptoms for at least three months will take either one of the drugs or a placebo for three months. The main…

This study is testing whether a gentle, non-invasive brain stimulation treatment can reduce severe fatigue and thinking problems in people with long COVID. Researchers will compare a real magnetic stimulation treatment to a fake one in 66 adults to see if it helps. They will also…

This study is testing if a simple, at-home heat therapy for the legs can help people with long COVID feel better and move more easily. Researchers want to see if warming the legs for about 45 minutes, several times a week, is safe and can improve walking distance, reduce fatigue,…

This study aims to understand why some people develop a fast heart rate and dizziness when standing up after having COVID-19, a condition called post-COVID-19 tachycardia syndrome. Researchers will compare 60 people—30 with these symptoms and 30 without—to see if reduced nerve ac…

This study aims to understand the brain changes linked to depression that starts after a COVID-19 infection. Researchers will use special brain scans to look at the brain chemistry of 90 adults who developed depression within 3 months of having mild or moderate COVID. The goal is…

This study aims to understand the long-term health effects of COVID-19 in adults who are about to have surgery. Researchers will survey 400 patients with a history of COVID to see what symptoms they still have and how severe their initial illness was. The goal is to gather inform…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…

This study is testing whether a weight loss medication called liraglutide (Saxenda) affects brain health markers in people with multiple sclerosis, long COVID, or leukemia in remission who also have obesity and cognitive problems. Researchers will measure changes in a protein cal…

This study aims to see if brain inflammation is present in people with Long COVID who have ongoing neurological symptoms like brain fog, headaches, and mood changes. Researchers will use a special brain scan (PET) with a tracer to look for inflammation in about 60 adults, compari…

This study aims to understand why some people develop long-lasting symptoms like fatigue, racing heart, and 'brain fog' after COVID-19, a condition often called Long COVID. Researchers will compare 150 people across three groups: those with Long COVID and POTS, those with POTS no…