LONG COVID

This study tests a comprehensive, remotely delivered care program for people aged 40 and older with Long COVID who have ongoing heart or lung symptoms like fatigue, shortness of breath, or chest pain. The program includes medication review, mental health support, telehealth coach…

This study tests a new supplement called PNMR in 82 adults with long COVID. Participants either take PNMR plus standard care or standard care alone for 6 weeks. The main goal is to see if PNMR helps people walk farther in a 6-minute test. All participants also get diet and lifest…

This study tests the safety of a drug called Anktiva in 40 adults with Long COVID—persistent symptoms after a COVID-19 infection. Participants receive the drug as a shot, and researchers monitor for side effects and changes in symptoms. The goal is to see if Anktiva is safe enoug…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This Phase 2 trial tests the safety of a drug called Anktiva (N-803) in 20 adults with Long COVID. Participants get up to two shots and are monitored for side effects and changes in immune cells and quality of life. The goal is to see if the drug is safe enough to study further f…

This expanded access program offers REGENECYTE, a human umbilical cord blood infusion, to adults with Long COVID who cannot join other clinical trials. Participants must have a recent negative COVID-19 test and provide consent. The goal is to provide potential treatment access wh…

This study tests if the drug anakinra can help people with long COVID who have ongoing breathing issues and signs of an overactive immune system. About 182 adults will receive either anakinra or a placebo for up to 8 weeks. The goal is to see if the drug improves lung function, r…

Some people with long COVID have harmful antibodies that may be attacking their own bodies, causing severe fatigue and other symptoms. This study tests a treatment called immunoadsorption, which filters the blood to remove those antibodies. About 70 participants will receive eith…

This study tests two drugs—pyridostigmine (Mestinon) and low-dose naltrexone (LDN)—alone or together in 160 adults with ME/CFS or Long COVID who also have orthostatic intolerance (difficulty standing). Over 3 months, participants take gradually increasing doses and complete exerc…

This study is testing whether a dietary supplement called MitoQ, combined with exercise rehabilitation, can improve blood vessel function in older adults (50+) suffering from long-COVID. The trial will enroll 300 participants, including both long-COVID patients and those who have…

This study tests whether a program of water-based exercise followed by memory training can help Veterans with long COVID symptoms like brain fog and fatigue. About 50 people will take part over 8 months. The goal is to see if the program is safe, doable, and helpful.

This Mayo Clinic pilot study tests whether breathing controlled levels of oxygen or carbon dioxide can help people with Long COVID brain fog. 45 participants will try short sessions of these gas mixtures and report changes in brain fog, fatigue, and blood flow. The goal is to see…

This study tests whether taking taurine supplements can reduce brain fog, memory problems, and fatigue in people with Long COVID. About 300 adults who had COVID-19 at least 3 months ago will take taurine or a placebo for 3 months. Researchers will measure changes in fatigue and t…

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This Phase 2 trial tests whether the drug plitidepsin can improve overall health in 90 adults with moderate-to-severe long COVID symptoms. Participants receive either plitidepsin or a placebo intravenously over four 3-day cycles, with a 90-day follow-up. The study is double-blind…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This Phase 3 trial tests two repurposed drugs—upadacitinib and pirfenidone—against a placebo in 348 adults with Long COVID. Participants from six countries will take the drugs for three months to see if they ease symptoms like fatigue, breathing trouble, memory issues, muscle pai…

This study tests a drug called DAOIB in 40 people with Long COVID who have memory and thinking problems (brain fog). Everyone gets the drug for 24 weeks, and researchers check their thinking skills, mood, and quality of life every 8 weeks. The goal is to see if DAOIB can help imp…

This study tests whether two HIV antiviral drugs, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may cause ongoing symptoms. 90 participants will take one of the drugs or a placebo daily for 90 days, and their health …

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study tests if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can ease lingering symptoms like brain fog and fatigue in people with Long COVID. Researchers will enroll 120 adults who had COVID-19 at least 3 months ago. The goal is to see if this t…

This study tests whether a mind-body intervention, including educational sessions and personalized support, can reduce long COVID symptoms like pain, fatigue, and dizziness. Researchers will compare it to usual care and another mind-body program in 180 adults. The goal is to see …

This study tests whether a single injection near a nerve cluster in the neck (stellate ganglion block) can reduce long COVID symptoms like fatigue, brain fog, and trouble breathing. About 40 adults with persistent symptoms will receive either the active injection or a placebo. Re…

This study tests a gentle brain stimulation technique called rTMS to see if it can reduce severe fatigue and concentration problems in people with long COVID. Researchers will give 66 adults either real or fake (placebo) stimulation over six weeks. The goal is to find a safe, non…

This pilot study will test whether acupuncture, with or without Chinese herbal medicine, is a practical and helpful treatment for long COVID. Ten adults with long COVID will receive 16 acupuncture sessions over 8 weeks; half will also take herbal supplements. The main goal is to …

This pilot study from Massachusetts General Hospital is testing whether whole body hyperthermia (like a sauna) can reduce Long COVID symptoms, especially fatigue. Researchers will enroll 21 adults aged 18-65 who have had COVID-19 at least 12 weeks prior. Participants will lie in …

This study tests whether at-home lower-body heat therapy can help older adults (ages 50-90) with long COVID improve their walking ability and overall physical function. Participants will use heat therapy at home, and researchers will measure changes in walking distance, physical …

This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different tre…

This study tests whether a 60-second ultrasound pulse to the brain can improve thinking and memory in people with long COVID brain fog. Forty participants will receive either real or fake (sham) stimulation, and their cognitive performance will be measured before and after. The g…

This study is testing whether a radioactive tracer called 11C-PS13 can detect brain inflammation in people who have long-term neurological symptoms after COVID-19. Researchers will compare PET scans from 60 adults (both healthy volunteers and those with long COVID) to see if the …

This study looks at long-term health problems in 400 adults who had COVID-19 and are now preparing for surgery. Researchers will ask about ongoing symptoms like breathing issues, heart problems, and fatigue. No new treatments are given; the goal is to understand how past COVID-19…

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, w…

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study follows 650 adults in Quebec to learn about the short- and long-term health problems caused by COVID-19, including damage to the heart, lungs, kidneys, and other organs. Participants include people who had mild, moderate, or severe COVID-19, as well as those who never …

This study looks at why some veterans experience ongoing brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these symptoms and identify target…

This study uses PET and MRI scans to look at brain changes in people who developed depression within three months after a mild or moderate COVID-19 infection. Researchers will compare brain scans of 90 participants to see if key brain chemicals are altered. The goal is to better …

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…