Could breathing your own air fix long COVID brain fog?
NCT ID NCT06928506
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different treatment doses to find the safest and most effective approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hi-OxSR device (rebreathing exhaled carbon dioxide)
What this could lead to
If it works, this could offer a simple, at-home treatment for brain fog and fatigue in Long COVID.
What could go wrong
This is an early phase 2 trial with only 120 people, so results may not apply to everyone. The treatment involves rebreathing CO2, which could cause discomfort or side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Hospitalier Universitaire de Sherbrooke
NOT_YET_RECRUITINGSherbrooke, Quebec, Canada
Contact Email: •••••@•••••
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Kaye Edmonton Clinic
NOT_YET_RECRUITINGEdmonton, Alberta, Canada
Contact Email: •••••@•••••
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University Health Network
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••