Could breathing your own air fix long COVID brain fog?

NCT ID NCT06928506

Recruiting now Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different treatment doses to find the safest and most effective approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hi-OxSR device (rebreathing exhaled carbon dioxide)
What this could lead to: If it works, this could offer a simple, at-home treatment for brain fog and fatigue in Long COVID.
What could go wrong: This is an early phase 2 trial with only 120 people, so results may not apply to everyone. The treatment involves rebreathing CO2, which could cause discomfort or side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LONG COVID are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID POST ACUTE SEQUELAE OF COVID-19 POST COVID-19 CONDITION

Contacts and locations

Locations

Centre Hospitalier Universitaire de Sherbrooke
NOT_YET_RECRUITING

Sherbrooke, Quebec, Canada
Kaye Edmonton Clinic
NOT_YET_RECRUITING

Edmonton, Alberta, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.