LONG COVID

This study is testing whether the drug sirolimus can prevent permanent lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. Hospitalized patients will be randomly assigned to receive different doses of sirolimus or standard care alone. Researchers will …

This study is testing whether a combination of two existing drugs can protect the heart in people with Long COVID who have developed heart inflammation. Researchers will give 279 participants either the active medication or a placebo for 16 weeks to see if it reduces symptoms lik…

This study is testing whether a one-time infusion of a lab-made antibody (AER002) can help people with Long COVID feel better. About 30 adults with persistent symptoms after a COVID-19 infection will receive either the antibody treatment or a placebo. Researchers will track chang…

This study is testing a new, non-invasive method to help diagnose Long COVID. Researchers will use a single-session procedure that measures the body's bioelectrical responses to see if patterns can indicate a persistent viral presence. The goal is to evaluate whether this approac…

This study is testing whether tailored light therapy or melatonin supplements can help people with Long COVID who are struggling with severe sleep problems like insomnia or daytime sleepiness. It's a Phase 2 trial involving 470 participants across multiple centers. The goal is to…

This study is testing different treatments to help people with Long COVID who get very tired and feel worse after even light exercise. It will enroll 360 participants across multiple centers to see if certain interventions can help them walk longer, do more daily activities, and …

This small pilot study is exploring whether ketamine, a medication used for anesthesia and depression, can help relieve the persistent fatigue and cognitive problems ('brain fog') experienced by people with Long COVID. Twenty adults will receive four ketamine injections over two …

This study is testing a new therapy called Cognitive Muscular Therapy (CMT) to help people with Long COVID who have trouble breathing. The therapy uses a special system to show patients how their breathing muscles are working in real-time, combined with physical training. Researc…

This study is testing whether the medication tirzepatide (brand name Zepbound) can reduce symptoms of Long COVID, especially severe fatigue. It involves 1,000 adults in the U.S. with Long COVID who will be randomly assigned to take either the real medication or a placebo pill for…

This study is testing new rehabilitation exercises that combine physical and mental tasks, like walking while solving a puzzle, to help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. The goal is to see if these 'dual-task' exercises, often supported b…

This study is testing whether a psychological therapy called Balance Acceptance and Commitment Therapy (ACT) can improve quality of life for people with long COVID. Researchers are comparing the therapy against standard self-help information in 196 UK adults who have had COVID sy…

This study is testing different treatments to help people with Long COVID who struggle with severe sleep problems like extreme daytime sleepiness and insomnia. About 361 participants will be assigned to receive either an active treatment or a placebo based on their specific sleep…

This study aims to see if eating a diet high in fermented foods like yogurt, kefir, and kimchi can change the mix of bacteria in the gut (the microbiome) of people with long COVID. Researchers at Mayo Clinic will enroll 40 adults with long COVID and randomly assign half to eat 6+…

This study aims to understand why veterans with Long COVID experience such severe and persistent fatigue. Researchers are measuring muscle function and oxygen use to find the cause. They are also testing if a simple, once-a-week home exercise program is safe and feasible for this…

This study aims to understand if a specific problem with the body's immune T-cells is causing symptoms in people with long COVID, chronic Lyme disease, or ME/CFS (chronic fatigue syndrome). Researchers will observe 160 people, including healthy volunteers, by taking blood samples…