LONG COVID

This study looks at 108 people with Long-COVID who have new chest pain. It tests if a treatment plan based on special heart tests works better than usual care to reduce chest pain and improve quality of life. Participants are followed for 12 months to see how they feel.

This study planned to test a blood-filtering device called Seraph 100 in 100 adults with long COVID. Participants would receive two filtering sessions on consecutive days, then be checked at day 3 and week 4 for safety and effectiveness. However, the study was withdrawn before en…

This study looks at whether low dose rapamycin can reduce symptoms and improve quality of life in people with ME/CFS or Long-COVID. Researchers will track symptom changes and measure blood markers related to cell cleanup (autophagy). 150 participants will take rapamycin prescribe…

This study tests whether the drug sirolimus can prevent long-term lung scarring (pulmonary fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults who need extra oxygen will receive sirolimus to see if it reduces the chance of developing fibrosis. The goa…

This study tests whether the antiviral drug ensitrelvir can help people with long COVID by targeting leftover virus in the body. About 40 adults with long COVID symptoms will receive either the drug or a placebo for 10 days. Researchers will measure changes in physical health and…

This study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and prevent heart damage in people with Long COVID who have ongoing heart inflammation. About 279 adults with persistent heart-related symptoms and MRI evidence of inflammat…

This study aims to see if a non-invasive diagnostic test using electroacupuncture can detect signs of long COVID in 50 adults. Participants will undergo a single session where their body's electrical responses to certain substances are measured. The goal is to find a faster, pers…

This study looks at whether eating fermented foods (like yogurt, kimchi, or sauerkraut) can increase the variety of good bacteria in the gut and reduce long COVID symptoms such as fatigue, anxiety, and depression. About 40 adults with long COVID will track their food and provide …

This study tests a psychological therapy called Balance ACT for people with Long COVID. The goal is to see if it improves quality of life compared to usual care. 196 adults with Long COVID are taking part.

This study tests different treatments to help people with Long COVID who have trouble exercising and feel very tired after activity. About 360 adults will be randomly assigned to a treatment or a control group. The main goal is to see if the treatments improve how long they can w…

This study tests whether tirzepatide (Zepbound), a medicine used for diabetes and weight loss, can reduce Long COVID symptoms like fatigue. About 1000 adults with Long COVID will take either the drug or a placebo for 12 months. All tasks are done from home using surveys and weara…

This study tests different treatments to help people with Long COVID who have trouble sleeping. It includes 470 adults and uses sleep tracking devices and questionnaires to see if targeted therapies improve sleep and reduce daytime tiredness. The goal is to find better ways to ma…

This small pilot study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, quality …

This study tests whether a lab-made antibody called AER002 can safely help adults with Long COVID feel better. Long COVID may be caused by leftover virus in the body, and this antibody aims to target that virus. 36 participants will receive either the antibody or a placebo, and r…

This study tests different treatments for sleep problems caused by Long COVID. About 361 adults with sleep issues like daytime sleepiness or insomnia will receive a treatment matched to their specific sleep problem. The goal is to see if these treatments can improve sleep and red…

This study explores whether combining physical and mental tasks (like walking while solving a puzzle) can improve rehabilitation for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will test these strategies in small groups to see if they a…

This study aims to understand why veterans aged 50 and older feel extremely tired after a COVID-19 infection. Researchers will measure muscle strength and fatigue levels, and test if a simple, home-based resistance exercise program is safe and practical for these veterans. The go…

This early-phase study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-protective protein called BDNF in people with multiple sclerosis, long-COVID, or acute leukemia (in remission) who also have obesity and memory or thinking problems. …

This study uses advanced MRI scans with special gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 patients over several years to track lung changes. The goal is to better understand why some people have severe breathing proble…

This study is for people with Long COVID, Lyme disease, or Chronic Fatigue Syndrome (ME/CFS) who have had symptoms for at least 6 months. Researchers will use a special blood test to check if T cells (a part of the immune system) are not working properly. Participants give a bloo…

This study aims to create a test that can predict how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' populations, using both clinical data and molecular markers. The goal is to …

This study looks at whether light, self-paced swimming is a safe and tolerable activity for people with ME/CFS and related conditions like Long COVID and POTS. Participants use a phone app to track their symptoms and heart rate variability before and after swimming. The goal is t…