Could this pill clear long COVID brain fog? new trial begins

NCT ID NCT06847191

Ongoing Symptom relief Sponsor: BioVie Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called bezisterim (NE3107) in 203 adults with long COVID who struggle with brain fog and fatigue. Participants take either the drug or a placebo twice daily for 84 days, and researchers measure changes in thinking, memory, and energy levels. The goal is to see if bezisterim can ease these lingering neurological symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bezisterim (NE3107)
What this could lead to: If it works, this could point toward a treatment for the brain fog and fatigue that plague many long COVID patients.
What could go wrong: This is an early Phase 2 proof-of-concept study, not a large definitive trial. The primary goal is to generate ideas, not prove success, so results may be unclear or not lead to a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 Fatigue long COVID-19 Mental Fatigue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID

Contacts and locations

Locations

Centricity Research

Columbus, Georgia, 31904, United States
Chronicle Bio Inc.

Park City, Utah, 84119, United States
Clinical Trial Site

Jacksonville, Florida, 32258, United States
Clinical Trial Site

Farmington Hills, Michigan, 48334, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Illinois Research Network University of Illinois at Chicago

Chicago, Illinois, 60608, United States
Jadestone Clinical Research

Silver Spring, Maryland, 20904, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Infectious Disease Institute

Louisville, Kentucky, 40202, United States
Stanford University

Palo Alto, California, 94304, United States
Swedish Center for Research and Innovation

Seattle, Washington, 98104, United States
UCSF

San Francisco, California, 94110, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Texas health Science Center at San Antonio

San Antonio, Texas, 78229, United States
West Virginia University

Morgantown, West Virginia, 26506, United States
Yale University

New Haven, Connecticut, 06519, United States
Zenos Clinical Research

Dallas, Texas, 75230, United States

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