LONG COVID

This study tested whether the antiviral drug Paxlovid can help people with Long COVID by clearing leftover virus or calming an overactive immune system. Nearly 1,000 adults took either Paxlovid or a placebo for different lengths of time. Researchers tracked improvements in thinki…

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This study tested the antiviral drug Paxlovid in 963 adults with Long COVID. The goal was to see if clearing leftover virus or calming the immune system could ease symptoms. Participants received either a 25-day or 15-day course of Paxlovid or a placebo. The trial is complete, bu…

This study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, brain scans, and inf…

This completed trial tested whether fluvoxamine, an FDA-approved drug for OCD, can improve long COVID symptoms like trouble concentrating, anxiety, depression, and fatigue. 191 adults from Missouri and Illinois who had COVID at least 3 months earlier took either fluvoxamine or a …

This study tested a 20-session physical rehabilitation program for 74 adults with long COVID. The program included treadmill walking and stretching, with intensity increasing over time. Researchers measured handgrip strength and walking ability before and after the program to see…

This study tested different treatments to help with sleep problems caused by Long COVID. It involved 361 adults and looked at improving daytime sleepiness and overall sleep quality. The goal was to find which treatments work best for these specific sleep issues.

This study tested two simple treatments—melatonin pills and tailored light therapy—to help people with Long COVID who have trouble sleeping. About 470 participants were randomly assigned to receive either melatonin, a placebo, or light therapy. The goal was to see if these treatm…

This completed study looked at whether a once-a-week home-based resistance exercise program could help reduce fatigue in veterans aged 50 and older with Long COVID. The study enrolled 21 participants and measured changes in muscle strength and perceived tiredness. The goal was to…

This study tested whether a low-sugar diet, eating only during a 8-12 hour window each day, and periodic water fasts could reduce Long COVID symptoms. 77 adults with at least five Long COVID symptoms participated. The goal was to see if these dietary changes could lower symptom s…

This study tested whether acupuncture can reduce pain and improve daily life for people with long COVID. 93 adults with persistent pain after COVID-19 were randomly assigned to receive 8 acupuncture sessions or continue their usual care. Researchers measured pain intensity and it…

This study tested a therapy called Cognitive Muscular Therapy (CMT) for people with Long-COVID who have trouble breathing. CMT combines breathing retraining with techniques to reduce overactive muscles that can interfere with breathing. 18 adults with moderate to severe breathles…

This study tested a structured pacing program for 300 people with Long COVID who experience exercise intolerance and post-exertional malaise. Participants worked with a pacing coach for 12 weeks to manage their activity and symptoms. The goal was to see if pacing could improve ex…

This study tested Pycnogenol, a natural pine bark extract, against a placebo in 153 adults with Long COVID. The goal was to see if it improves overall health and reduces symptoms like fatigue and brain fog. Participants took the supplement for 12 weeks and reported their health s…

This study tested whether a 12-week exercise program done at home via video calls could help people with long COVID feel better. 120 adults aged 20-80 with long COVID took part. The program aimed to reduce symptoms like fatigue and brain fog, and improve fitness and quality of li…

This study tested a virtual attention training program for 58 adults with Long-Covid brain fog. The goal was to see if the program is feasible and improves focus and thinking. Participants completed sessions online, and researchers measured attention changes before and after trai…

This completed Phase 2 study tested whether the oral drug Xiflam (tonabersat) can safely reduce symptoms of Long COVID compared to a placebo. Sixteen adults who had COVID-19 and then developed lasting symptoms for at least 12 weeks took part. Participants received either Xiflam o…

This Canadian trial tested two drugs, ibudilast and pentoxifylline, against a placebo in 460 adults with lingering COVID-19 symptoms. Participants took the drugs for 2 months and were followed for 4 more months to see if symptoms improved. The goal is to find safe, effective trea…

This study looked at whether eating 2 ounces of walnuts every day for 12 weeks could improve memory and reduce brain fog in adults over 40 with Long-COVID. About 31 people took part, comparing walnut eaters to those getting usual care. The goal was to see if walnuts, which are ri…

This completed Phase 2 trial tested whether ivabradine, a drug that slows heart rate, can reduce symptoms like dizziness and rapid heartbeat in people with long COVID. 181 participants received either ivabradine or a placebo for 3 months, with follow-up for another 3 months. The …

This study tested whether amantadine, a medication used for other conditions, can improve memory and thinking problems in people with Long COVID. 64 adults with lasting cognitive issues after a COVID infection took part. Researchers also looked for lab markers that might predict …

This study tested a 6-week outpatient rehab program for 125 adults with Long COVID. The program included physical and speech therapy tailored to each person's needs, aiming to improve breathing, thinking, and daily function. Researchers measured progress using a six-minute walk t…

This study tested different treatments for sleep problems caused by Long COVID. It included 830 adults who had COVID-19 and now have trouble sleeping or feel very sleepy during the day. The goal was to see if treatments matched to specific sleep issues could help people feel bett…

This study tested whether qigong, a gentle practice of slow movements and meditation, could improve quality of life for people with Long COVID. Forty adults with symptoms lasting over 12 weeks attended six weekly group sessions. Researchers measured changes in physical and mental…

This completed pilot study tested a daily ultrasound device applied to the spleen for 8 weeks in 15 adults with Long COVID. The goal was to see if it safely improves symptoms like fatigue, pain, and brain fog. Researchers measured walking endurance and fatigue levels before and a…

This study tested an oral drug called LAU-7b (fenretinide) in 272 adults with moderate to severe Long COVID symptoms lasting at least 12 weeks. Participants took the drug or a placebo in cycles of 14 days on, 14 days off, for 12 weeks. The main goal was to see if LAU-7b improves …

This completed study tested a dietary supplement containing quercetin and curcumin in 15 adults with mild to moderate Long COVID symptoms like fatigue, brain fog, and body pain. Participants took two capsules twice daily for 8 weeks. The goal was to see if the supplement could re…

This study tested different treatments to help people with Long COVID who struggle with exercise and feel very tired after activity. Researchers enrolled 660 adults across multiple medical centers to see if these treatments could improve exercise ability, daily activity, and qual…

This study tested an 8-week tele-rehabilitative exercise program for nurses with long COVID. The program included aerobic and strengthening exercises done at home using a wearable knee brace and a smartphone app. Researchers measured changes in fatigue, heart and lung fitness, lo…

This study tested whether taking Paxlovid for 15 days can reduce severe Long COVID symptoms like fatigue, brain fog, and shortness of breath. 168 adults with persistent symptoms after COVID-19 took either the drug or a placebo. Researchers tracked symptom severity over 15 weeks t…

This study tested a program for people with long-COVID that includes an online screening, a detailed in-person assessment, and digital training modules with a personal counselor. 192 participants from Bavaria took part to see if this approach is practical and helpful. The goal wa…

This study interviewed 25 adults with long COVID to understand how the condition affects their daily life, work, and experience with healthcare. Researchers aimed to learn about the challenges patients face and what helps or hinders their return to work. The study does not test a…

This study reviewed medical records of 200 adults from an endocrinology clinic to see if taking vitamin D3 supplements lowered their chances of developing Long COVID after a COVID-19 infection or getting COVID-19 after vaccination. Researchers compared patients who took vitamin D…

This completed study took blood samples from 62 people with Long COVID and compared them to healthy controls. Researchers looked for specific immune and metabolic patterns that might explain why symptoms persist. The goal is to better understand Long COVID, not to test a treatmen…

This study followed 171 people with Long COVID who had brain fog and other thinking problems. Researchers looked at what treatments patients received and how their quality of life changed over 6 months. The goal was to see if certain treatments helped improve daily functioning. B…

This study followed over 4,200 Dutch COVID-19 patients for up to two years to learn about long COVID symptoms like exhaustion, breathing problems, and mental health issues. Researchers also looked at how these symptoms affect quality of life and what factors might predict who get…

This study looked at whether chronic stress before catching COVID-19 makes long COVID more likely. Researchers followed 380 adults who tested positive for SARS-CoV-2 and had symptoms. They measured stress levels and tracked whether symptoms lasted beyond four weeks. The goal is t…