Antidepressant drug could ease long COVID brain fog and fatigue
NCT ID NCT05874037
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed trial tested whether fluvoxamine, an FDA-approved drug for OCD, can improve long COVID symptoms like trouble concentrating, anxiety, depression, and fatigue. 191 adults from Missouri and Illinois who had COVID at least 3 months earlier took either fluvoxamine or a placebo. Participants rated their symptoms daily to see if the drug helped reduce their severity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fluvoxamine
What this could lead to
If it works, this could point toward a treatment for long COVID symptoms like fatigue, anxiety, and trouble concentrating.
What could go wrong
This is a small, completed trial with 191 participants, so results may not apply to everyone. Fluvoxamine is an antidepressant, and its benefits for long COVID are not proven yet.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
St Louis, Missouri, 63110, United States