Can tailored rehab help long COVID patients get moving again?

NCT ID NCT06404060

Completed Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests whether a personalized cardiopulmonary rehabilitation program can help people with Long COVID who struggle with exercise intolerance and post-exertional malaise. About 360 participants will do 2-3 supervised sessions per week for 12 weeks, including aerobic exercise, strength training, and education. The goal is to improve walking endurance, daily activity tolerance, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized cardiopulmonary rehabilitation (exercise and education sessions)
What this could lead to: If it works, this could provide a safe, structured exercise program to help people with Long COVID walk longer and feel better in daily life.
What could go wrong: This is a relatively small, early-stage study without a placebo control, so results may not apply to everyone. Some participants may not improve or could feel worse due to post-exertional malaise.

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Conditions

The condition(s) this trial relates to.

long COVID-19 Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID LONG COVID-19 LONG COVID19

Contacts and locations

Locations

All sites listed under NCT06404047

Durham, North Carolina, 27710, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.