Hormone injection reveals how long COVID affects the brain

NCT ID NCT07224490

Recruiting now Knowledge-focused Sponsor: Stephanie B. Seminara, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, which could lead to better insights into related health issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Kisspeptin (a natural hormone given as a single injection)
What this could lead to: If successful, this could help explain how Long COVID affects the brain's reproductive hormone system, pointing toward future treatments for related symptoms.
What could go wrong: This is a very early Phase 1 study with only 40 participants, so results may not apply broadly. It is designed to measure hormone responses, not to test a treatment, so direct benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LONG COVID are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

COVID-19 long COVID-19 Nerve Degeneration neurodegenerative disease post-COVID-19 disorder reproductive system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID NEURODEGENERATION REPRODUCTIVE DISORDER SARS-COV-2

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.