A One-Two punch for long COVID? supplement and therapy put to the test
NCT ID NCT05703074
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This trial tests two potential approaches for long COVID: a dietary supplement called nicotinamide riboside (NR) and a mind-body reprocessing therapy (MBRT). The study includes 310 adults aged 18-70 with long COVID symptoms that interfere with daily life. Participants are randomly assigned to receive NR or placebo, and MBRT or usual care, for three months. The goal is to see if these interventions improve health-related quality of life, with follow-up over a year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Nicotinamide riboside (NR) dietary supplement and mind-body reprocessing therapy (MBRT)
- What this could lead to
- If successful, this could point toward effective treatments for long COVID, improving quality of life for millions.
- What could go wrong
- This is a phase 2 trial, so results are preliminary. The supplement and therapy may not outperform placebo or usual care, and side effects or lack of adherence could limit benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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310 people
The number who actually took part.
- Started
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Jan 2023
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Undergone acute COVID-19, confirmed EITHER by a positive PCR-test OR a positive self-test combined with confirmatory antibody-pattern in blood. * Persistent symptoms at least 6 months following acute COVID-19 without symptom-free interval. * Functional disability to an extent that impacts negatively on normal activities (such as work attendance, physical exercise, social activities, etc.) * Informed consent Exclusion Criteria: * Other chronic illnesses, demanding life situations or concomitant drug use/substance abuse that is considered a plausible cause of persistent symptoms and associated disability * Sustained organ damage (lung, heart, brain) following acute, serious Covid-19 * Pregnancy. * Bedridden * Insufficient command of Norwegian
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Akershus University Hospital
Lørenskog, 1478, Norway
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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