Long COVID-19

This Phase 3 trial tests whether dapagliflozin, a drug used for diabetes, can improve quality of life in people with long COVID. 192 adults with persistent symptoms for at least 12 weeks after a COVID infection will receive either the drug or a placebo daily for 12 months. The ma…

This study tests whether two FDA-approved drugs, maraviroc and atorvastatin, can help people with Long COVID. 252 adults aged 18-65 with persistent symptoms will take either the drug combination or a placebo for 16 weeks. The main goal is to see if it reduces fatigue and improves…

This phase 2 trial tests whether a combination of three drugs—valacyclovir, celecoxib, and Paxlovid—can reduce Long COVID symptoms in adults. About 150 participants aged 18-65 with diagnosed Long COVID will receive either the drug combo or a placebo. The main goal is to see if th…

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

This study investigates whether taking taurine—a natural amino acid found in the body and sold as a supplement—can help adolescents aged 10 to 17 who have Long COVID. Researchers will measure taurine levels in the blood and track changes in symptoms like fatigue, brain fog, and m…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This small pilot study tests whether adding mild electrical stimulation to simple breathing exercises can improve breathing, reduce fatigue, and boost quality of life in people with Long COVID. Ten adults aged 18-65 with a Long COVID diagnosis will be split into two groups: one d…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests a group therapy program called HOPE-LC~Español for Spanish-speaking adults with Long COVID. The program teaches coping skills and resilience. Researchers will enroll 25 people in Queens to see if the program is helpful and practical.

This study tests a supervised online program called SuperCAP to see if it can improve thinking and daily functioning in people with long COVID. One hundred adults with post-COVID cognitive difficulties will either use the program or receive standard education. The goal is to redu…

This study tests whether a natural supplement (made from orange, grapefruit, olive leaf, and other plant extracts) combined with a personalized exercise program can help people with long COVID. The trial will include 40 adults who still have symptoms like inflammation and fatigue…

This study tests whether acupuncture can improve thinking and memory problems in people with Long COVID. 108 adults with brain fog will get real acupuncture, fake acupuncture, or no treatment for 8 weeks. Researchers will also use brain scans to see if acupuncture changes how bra…

This study tests whether acupuncture can improve thinking and memory problems (brain fog) in people with chronic fatigue syndrome (ME/CFS) that started after COVID-19. About 99 adults will be randomly assigned to real acupuncture, fake acupuncture, or a waiting list for 8 weeks. …

This study tests whether a whole-body electrostimulation suit can reduce fatigue and improve physical function in people with Long COVID. 30 adults with persistent symptoms will be randomly assigned to receive either active stimulation or a placebo version during 12 weekly sessio…

This phase 3 trial tests whether a single infusion of human umbilical cord blood, called REGENECYTE, can reduce fatigue in people with Long COVID. Sixty adults with post-COVID condition will receive either the cord blood or a placebo (salt water) and be monitored for changes in f…

This study tests whether a non-invasive device that gently stimulates nerves can help people with long COVID symptoms like muscle pain, breathing issues, and loss of taste or smell. About 104 adults who had COVID-19 and still have symptoms for at least 30 days will receive either…

This study will follow over 5,000 adults with Long COVID for two years each to understand how the condition changes over time, who recovers, and what new illnesses may develop. Researchers will focus on brain fog, heart and lung problems, and chronic fatigue. No drugs or treatmen…

This study will use the Long COVID Companion app to collect voice recordings and health questionnaires from 300 adults with ongoing COVID-19 symptoms. Researchers hope to identify vocal biomarkers for common issues like fatigue, brain fog, and breathing problems. The goal is to e…

This study looks at how intranasal IVIG (a treatment given through the nose) might help people with Long COVID who also have a weak immune system. Researchers will collect health data from 50 participants, but no treatment is given as part of the study. The goal is to see if this…

This study will use a non-invasive imaging method called electrical impedance tomography (EIT) to measure how air moves through the lungs of 50 people with ongoing symptoms after COVID-19. Researchers will compare EIT results with standard CT scans and lung function tests to see …