Can our genes and gut explain long COVID?

NCT ID NCT07757620

Not yet recruiting Knowledge-focused Sponsor: Istituti Clinici Scientifici Maugeri SpA Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This observational study aims to uncover the biological mechanisms behind long COVID by comparing adults with long COVID, those who fully recovered from COVID-19, and healthy controls. Researchers will analyze blood and, when available, intestinal tissue to examine gene activity, DNA methylation, immune cell profiles, and gut microbiome composition. The goal is to identify molecular biomarkers that could improve diagnosis, patient stratification, and future precision medicine approaches for long COVID.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify biomarkers for diagnosing long COVID and point toward new treatments targeting the gut-immune axis.
What could go wrong: As an observational study, it cannot prove cause and effect. Findings may not translate into therapies, and the complexity of long COVID may limit generalizability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG COVID SYMPTOMS LONG COVID-19 SYNDROME

Contacts and locations

Locations

Istituti Clinici Scientifici Maugeri

Pavia, 27100, Italy
Istituto Auxologico Italiano

Cusano Milanino, Milano, 20095, Italy
Ospedale San Raffaele S.r.l.

Milan, 20132, Italy

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