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Mind over fatigue: could a 3-Day program tame long COVID?

NCT ID NCT07697261

Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This trial compares two approaches for managing long COVID fatigue: the Lightning Process, a mind-body program that teaches ways to change thought patterns and body responses, versus activity pacing, which helps balance rest and daily tasks. One hundred adults aged 18 to 65 with long COVID will be randomly assigned to one of the two groups. The study is conducted entirely online, and the main goal is to see which method better reduces fatigue after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lightning Process (mind-body intervention)
What this could lead to
If effective, this could offer a non-drug approach to manage long COVID fatigue and improve daily life.
What could go wrong
This is a small trial (100 people) testing a behavioral intervention, so results may not apply widely. The Lightning Process is not a medical treatment and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The inclusion criteria for participants are: 1. Adults aged 18 to 65 years 2. Meeting the WHO clinical case definition for long COVID and 3. Self-reported experiencing long COVID symptoms such as fatigue, muscle pain, and brain fog. 4. Reporting a minimum score of ≥35 on the Checklist Individual Strength CIS-fatigue domain. 5. Able to speak and read English 6. Scoring higher in contemplation, action or maintenance scores than the precontemplation phase on the readiness to change questionnaire 7. Provides consent for study participation. 8. Consistent access to an internet-connected device (e.g., smartphone, tablet, laptop) that can facilitate access to the study interventions. Exclusion Criteria: * The exclusion criteria are: 1. Long COVID participants whose presentation is primarily restricted to anosmia. 2. Participants with Post-Intensive Care Syndrome (PICS) or serious organic sequelae of COVID-19, such as structural lung injury attributable to mechanical ventilation or other organ damage requiring ongoing specialist management. 3. Participants who will not be able to attend intervention sessions or follow up visits due to anticipated significant life changes or relocation. 4. Unable to provide informed consent (e.g. cognitive disability, language barrier) 5. Co-morbidities that likely to impair function for as long or longer than long COVID 6. Current participation in psychotherapy, structured physical rehabilitation (e.g., physiotherapy or occupational therapy), or another trial that does not permit co-enrollment.

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Conditions

The condition(s) this trial relates to.

Fatigue long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Long COVID

How to take part

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  1. The official record

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    Open the record ↗

  2. A doctor treating you

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