Can computer games clear the fog? new study tests brain training for ME/CFS

NCT ID NCT07523113

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits. Thirty participants will train remotely over 2-4 weeks and be followed for 6 months to see if their thinking and daily activities improve.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
brain training (computer games and lifestyle coaching) plus non-invasive vagus nerve stimulation
What this could lead to
If it works, this could point toward a practical, at-home way to reduce brain fog and improve daily functioning for people with ME/CFS.
What could go wrong
This is a very small, early-stage study with only 30 participants. The two approaches are compared head-to-head, so neither may prove clearly better. Results may not apply to everyone with brain fog.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

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