FATIGUE

This study tests whether HBS-301 (pitolisant) can reduce excessive daytime sleepiness and cataplexy (sudden muscle weakness) in adults with narcolepsy. Participants receive either the drug or a placebo for several weeks, followed by an open-label phase where everyone gets the dru…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests whether shining a special light (photobiomodulation) on the thigh muscles before electrical stimulation can reduce fatigue, muscle damage, and soreness. 36 healthy adults will receive either real or fake light therapy, then undergo a series of electrical muscle c…

This study tests whether following a healthy US-style diet rich in anti-inflammatory foods can reduce fatigue and improve muscle and physical function in adults aged 50 and older with long COVID. Over 16 weeks, participants are randomly assigned to either receive personalized die…

This Phase 3 study tests whether Nuvastatic, a herbal supplement taken as a powder sachet three times daily, can reduce cancer-related fatigue in adults with stage IV colon cancer who are starting chemotherapy. About 180 participants will receive either Nuvastatic or a placebo fo…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study looks at whether two simple relaxation methods—progressive muscle relaxation and deep breathing exercises—can reduce shortness of breath and severe tiredness in people with advanced cancer receiving palliative care. About 90 participants will be assigned to one of the …

This study tests a physical activity program designed for cancer survivors and their caregivers. About 164 adults who have finished cancer treatment (except hormone therapy or maintenance chemo) will take part. The goal is to see if the program improves physical function and redu…

This pilot study in Singapore tests whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients. 100 women who have completed surgery and chemotherapy will be enrolled. The study focuses on wh…

This study tests whether combining psychoeducational sessions (like counseling and self-help strategies) with an open-label placebo can reduce fatigue in people with metastatic cancer. Participants will be assigned to one of three groups: education only, placebo only, or both. Th…

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in 100 adults with sarcoidosis. One group takes MBSR; the other joins a monthly virtual support group. Researchers will compare which approach …

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

This study is testing whether squeezing a stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will take part. Researchers will measure their symptoms during treatment to see if this simple, drug-free tool mak…

This study tests two online programs designed to help people with multiple sclerosis (MS) understand and manage their fatigue. Researchers will enroll 2,000 adults with MS across the U.S., including veterans, and compare the programs to usual care alone. The goal is to find pract…

This study is testing whether a daily testosterone gel can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. The trial involves 230 participants who will apply either the gel or a placebo for six months. Researchers will mea…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study looks at whether a type of talking therapy (cognitive behavioral therapy) can help reduce severe fatigue in primary care patients. About 190 adults aged 18-67 with long-lasting fatigue will either get the therapy or usual care. The goal is to see if the therapy improve…

This study tests whether a 12-week tele-exercise program called RISE-YA can help reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants receive energy conservation counseling, behavior coaching, and exercise training via video calls…

This study tests if a gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 people who are at least 3 months past their stroke and have significant fatigue. Participants will use a headset device daily, wi…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This pilot study tests a wellness program for adults with cystic fibrosis (CF) to see if it helps with fatigue, sleep, and physical activity. The program includes 8 coaching sessions on topics like balancing activity and rest, improving sleep, and managing stress. Researchers wil…

This study tests whether walking programs can reduce fatigue in older breast cancer survivors (age 60+). 24 participants will either walk at a center or at home. The goal is to find a practical way to improve energy and well-being after cancer treatment.

This study tests whether a gentle magnetic pulse to a specific brain area can reduce fatigue in people with multiple sclerosis. Sixty participants will receive either real or fake stimulation for 30 minutes daily over five days. Researchers will track changes in fatigue, brain ch…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether a device that sends gentle sound pulses to the brain can reduce fatigue, brain fog, and mood problems in people with long COVID. 102 adults who have had COVID-19 at least 12 months ago will receive either real or fake (sham) treatment over five sessions. …

This study tests whether taking a fisetin supplement can lessen fatigue in older adults who have survived cancer. About 60 people who finished cancer treatment more than a year ago will take fisetin or a placebo. Researchers will measure changes in fatigue levels using a standard…

This study is testing the safety of Niagen Plus, an injectable form of vitamin B3, in 40 healthy adults who feel tired. Participants will receive injections under the skin or into muscle over 100 days. Researchers will monitor side effects and measure changes in NAD+ levels, fati…

This pilot study tests whether taking a seaweed supplement called fucoidan for 8 to 16 weeks can reduce fatigue and inflammation in cancer survivors. Researchers will enroll 40 adults who have completed cancer treatment within the last 10 years and still feel tired. The main goal…

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study tests whether a simple, 45-minute resistance exercise program (using bands) can help breast cancer survivors manage fatigue. Researchers will enroll 60 women from different income backgrounds to see if the program is practical and if income affects how well people stic…

This study tests whether a daily supplement called APPORTAL® can reduce fatigue in breast cancer patients undergoing chemotherapy. The supplement contains a mix of vitamins, minerals, and other nutrients. 92 women will take either the supplement or a placebo for 8 weeks, alongsid…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study tests whether 16 weeks of aerobic exercise or cognitive behavioral therapy can reduce severe fatigue in people with myasthenia gravis, a muscle weakness condition. Sixty adults with stable MG will be randomly assigned to exercise, therapy, or usual care. The goal is to…

This study looks at how 'cognitive reserve' — the brain's built-in resilience built over a lifetime — affects recovery from daily physical and mental fatigue in people aged 65 and older. Researchers will measure cognitive reserve levels in 400 older adults and track how they perc…

This study is observing 40 adults with multiple sclerosis to see how clinical tests of balance and walking relate to detailed motion-capture measurements. Participants will attend one session where they walk on force plates and perform balance tasks while cameras track their move…

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study looks at whether low levels of immunoglobulin G (IgG), a type of antibody, are linked to fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue scores and infection rates between MS patients with low IgG and those with normal IgG. The goal is …

This study follows 100 adults with Sjögren's disease for 3 months to understand what causes their fatigue. Researchers will use questionnaires and pain tests to track fatigue, mood, sleep, and activity levels. The goal is to find factors that predict or explain fatigue, which cou…

This study tests whether a weak electrical current applied to the neck or upper back can change how muscles work and how tired they get. Healthy adults aged 18 to 50 will attend up to 6 sessions to measure force, effort, and muscle signals. The goal is to understand the effects, …

This study looks at why people with axial spondyloarthritis often feel very tired and how that relates to muscle function. Researchers will measure exercise capacity in 122 adults starting a new targeted therapy. The goal is to better understand the connection between fatigue and…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study looks at how cancer survivors describe their fatigue, a common and often misunderstood symptom. Researchers will interview 80 survivors and their doctors to find common themes and language. The goal is to create a visual aid (like a Venn diagram) to help patients and p…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…

This study looks at how the brain values mental and physical effort, and how fatigue and rewards change that value. About 185 healthy adults aged 18-35 will perform tasks like focusing attention or squeezing a grip while their brain activity is measured. The goal is to understand…

This study is testing different combinations of recorded exercise videos, health coaching, and live training sessions to see which approach helps people with physical disabilities stay physically active over 32 weeks. About 257 participants will wear a Fitbit to track their steps…

This study looks at why people with Long COVID (PASC) feel so tired. Researchers will use brain scans and effort-based tasks to compare 200 adults with and without Long COVID. The goal is to find brain changes that cause fatigue, which could lead to better treatments and rehab.

This study looks at how often fatigue occurs in people who have had their first stroke and what factors might make it worse. Researchers will measure fatigue using simple questionnaires and also check things like pain, mood, sleep, and physical ability. The goal is to better unde…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study will use smartphone recordings of speech, eye movements, and arm fatigue to measure key symptoms of myasthenia gravis, a condition that causes muscle weakness. Researchers will compare 225 participants (both with and without MG) to see if machine learning can accuratel…