FATIGUE

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy (CBT) can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least …

This study tests whether walking exercise can reduce fatigue in older breast cancer survivors (age 60+). About 24 participants will either walk at a center or at home. The goal is to see which approach better improves energy and quality of life after cancer treatment.

This study tests whether a special type of lighting that changes throughout the day can improve sleep, body clock function, and overall well-being in frail adults over 65 who are staying in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The…

This study tests two online programs designed to help people with multiple sclerosis (MS) manage their fatigue. Researchers will enroll 2,000 adults with MS across the U.S., including veterans, and compare the programs against usual care alone. Participation lasts one year, with …

This study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can reduce fatigue in people with multiple sclerosis (MS). Sixty participants will receive either real or sham (fake) stimulation for 30 minutes daily ov…

This study trains psychotherapists to give personalized talk therapies to cancer patients and their caregivers who are feeling high levels of distress. Therapists will choose from proven treatments like cognitive behavioral therapy or mindfulness to address issues such as anxiety…

This study tests whether taking a supplement called fisetin can reduce fatigue in older adults who have survived cancer. Researchers will enroll 60 people and measure changes in tiredness using a standard questionnaire. The goal is to find a safe, easy way to improve energy and q…

This study looks at whether a simple resistance exercise program can help breast cancer survivors manage fatigue. About 60 people who had breast cancer will follow a strength training guide for 3 months and track their progress. The goal is to see if the program works for people …

This small study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other symptoms in people with post-COVID condition. Researchers will enroll 40 adults who have had symptoms like chronic tiredness for at least 12 week…

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks and be followed for 12 more weeks. Researchers will measure sleep, mood, fatigue, and signs …

This study looks at whether using a simple stress ball during chemotherapy can help stomach cancer patients feel less nauseous, anxious, and tired. About 52 adults with stomach cancer will be asked to squeeze a stress ball while receiving their chemo treatment. The goal is to see…

This study tests if aerobic exercise or cognitive behavioral therapy can help reduce fatigue in people with myasthenia gravis, a muscle weakness condition. About 60 adults with stable MG will be randomly assigned to exercise, therapy, or usual care. The goal is to see if these ap…

This study tests whether testosterone replacement can help older men (55+) with cancer who feel very tired and have low testosterone. About 230 men will receive either testosterone or a placebo to see if it improves fatigue and sexual function. The goal is to improve quality of l…

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study tests a non-invasive treatment called transcranial pulse stimulation (TPS) for people with Post-COVID syndrome who suffer from fatigue, memory problems, or low mood. About 102 adults who had COVID-19 at least 12 months ago will receive either real TPS or a sham treatme…

This study tests whether combining psychoeducational interventions (like counseling and self-help strategies) with an open-label placebo pill can reduce fatigue in people with advanced or metastatic cancer. About 240 adults with moderate-to-severe fatigue will be enrolled. The go…

This study tests the safety of Niagen Plus, an injectable form of vitamin B3, in 40 healthy adults with fatigue. Participants receive injections under the skin or into muscle for about 100 days. Researchers check for side effects and measure NAD+ levels in the blood, which may he…

This study tests if a safe, gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 adults who are at least 3 months past their first stroke and have significant fatigue. Participants will use a headset devi…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. Fatigue is a common and disabling symptom after stroke. The trial will enroll 60 participants and measure changes in fa…

This study looks at whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take part. Researchers will measure muscl…

This study tests whether a supplement made from seaweed, called fucoidan, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study tests whether a special nutrient supplement (APPORTAL®) can help reduce severe tiredness in women with breast cancer who are on chemotherapy. About 92 participants will take either the supplement or a placebo for 8 weeks, along with recommended exercise. Researchers wi…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study looks at whether exercise therapy and cognitive behavioral therapy (a type of talk therapy) can help reduce fatigue in women with breast cancer. About 100 female patients in Singapore will take part. The goal is to see if these treatments are acceptable, culturally sen…

This study tests a wellness program for adults with cystic fibrosis who feel very tired. The program includes coaching sessions to help improve fatigue, sleep, and physical activity. Researchers will see if people stick with the program and if it helps them feel better compared t…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to other issues like fatigue, depression, anxiety, and bladder problems. Researchers will use questionnaires to gather information from 140 women with relapsing-remitting…

This study looks at how often fatigue happens after a person's first stroke and what factors—like pain, mood, or sleep—make it worse. Researchers will follow 107 adults who had a stroke at least three months ago. The goal is to better understand post-stroke fatigue so doctors can…

This study will use smartphone recordings to measure common symptoms of myasthenia gravis, like slurred speech, voice changes, arm fatigue, and droopy eyelids. Researchers will compare 225 people with and without MG to see if machine learning can tell them apart. The goal is to d…

This study tests whether a weak electrical current applied to the neck or upper back can change how muscles work and how tired they get. Healthy adults aged 18 to 50 will attend up to 6 sessions to measure muscle force, effort, and activation. The goal is to understand the effect…

This study looks at why people with Long COVID (PASC) feel so tired. Researchers will use brain scans and simple grip-strength tasks to compare 200 adults with and without Long COVID. The goal is to find brain changes that cause fatigue, which could lead to better treatments down…

This study aims to understand the different types of fatigue people experience, especially those with conditions like cancer, lupus, or chronic fatigue syndrome. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and option…

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…

This study tests different ways to help 257 adults with physical disabilities stick to a home exercise program. Participants get access to exercise videos and wellness articles, and some also receive health coaching calls. The goal is to see which combination of support works bes…

This study aims to understand how the brain decides how much effort to put into tasks, both mental and physical. Researchers will observe 185 healthy adults using brain scans and behavioral tests to see how fatigue and rewards change our perception of effort. The goal is to learn…

This study looks at why some people who have had a stem cell transplant continue to feel extremely tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand t…

This study looks at how fatigue and muscle function are connected in people with axial spondyloarthritis, a type of inflammatory arthritis. Researchers will measure exercise capacity and muscle strength in 122 adults starting a new targeted therapy. The goal is to better understa…

This study aims to understand what causes fatigue in people with Sjögren's disease. About 100 adults will complete surveys and pain tests at the start and again after 3 months. No new treatments are given; the goal is to gather information to help future care.

This study looks at whether a type of talking therapy (transdiagnostic cognitive behavioral therapy) can help reduce fatigue in primary care patients. About 190 adults aged 18-67 with severe fatigue lasting at least 3 months will be randomly assigned to either the therapy or usua…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates between MS patients with and without low antibody levels. The goal is to und…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…