Scientists scan brains to unlock the mystery of mental and physical tiredness
NCT ID NCT04041154
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the brain values mental and physical effort, and how fatigue and rewards change that value. About 185 healthy adults aged 18-35 will perform tasks like focusing attention or squeezing a grip while their brain activity is measured. The goal is to understand the brain circuits behind effort and fatigue, not to test any treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could help scientists better understand why people feel tired and how motivation affects effort, potentially guiding future treatments for fatigue.
- What could go wrong
- This is a basic science study, not a treatment trial. It is small and early-stage, so results may not directly lead to any therapy or apply to real-world fatigue.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kennedy Krieger Institute
RECRUITINGBaltimore, Maryland, 21209, United States
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