FATIGUE

This study is testing whether a 16-week program of aerobic exercise or cognitive behavioral therapy (a type of talk therapy) can reduce severe fatigue in people with myasthenia gravis. It will involve 60 participants who will be randomly assigned to one of these programs or to co…

This study is testing the safety of a new injectable supplement called Niagen® Plus in healthy adults who experience fatigue. Over 100 days, 40 participants will receive injections to see how well the body tolerates them and if they affect energy-related markers in the blood. The…

This small pilot study is testing whether taking a supplement made from seaweed, called fucoidan, for 8 weeks can help reduce fatigue and inflammation in people who have finished cancer treatment. The researchers will enroll 40 adult cancer survivors who report significant fatigu…

This study aims to see if combining talk therapy (CBT) with light therapy, medication, or melatonin can help improve sleep quality, fatigue, anxiety, and depression in people with advanced cancer. Researchers will compare these active treatments against placebo (inactive) treatme…

This study is testing whether a 12-week program of exercise therapy, with or without cognitive behavioral therapy (CBT), can help reduce fatigue in women who have been treated for breast cancer. The researchers want to see if these programs are practical and acceptable to patient…

This study is testing a personalized, 32-week online exercise program to help people with mobility disabilities become more physically active. Researchers are using a smart trial design to see if adding health coaching calls or live group training helps participants stick with th…

This small pilot study is exploring whether hyperbaric oxygen therapy (HBOT) can help people suffering from Long COVID. Participants with persistent symptoms like fatigue and 'brain fog' will spend time in a pressurized chamber breathing pure oxygen to see if it improves their co…

This study is testing whether an 8-week online mindfulness program can help reduce the severe fatigue often experienced by people with sarcoidosis. It will also see if the program improves symptoms of anxiety and depression. Researchers will compare the mindfulness group to a mon…

This study is testing whether a 3-month strength training program is a practical way to help breast cancer survivors in Appalachia manage their fatigue. Researchers want to see if people with different income levels can stick with the program. The main goal is to understand what …

This study is testing whether using the Calm meditation app for 10 minutes a day can help people with blood cancers who have trouble sleeping. Researchers will enroll 276 patients to see if the app improves sleep quality, reduces fatigue and anxiety, and lowers body inflammation …

This study is testing a new therapy program designed to help people with long-term, disabling fatigue. It will compare a special type of talk therapy (tCBT) delivered partly online and partly in person to the usual care patients receive from their doctor. Researchers want to see …

This study is testing whether a safe, non-invasive brain stimulation device used at home can reduce severe fatigue in people who have had a stroke. Twenty-four participants will use the device daily for two weeks, with half receiving a real treatment and half receiving a sham (pl…

This large study is testing whether two different online educational programs can help people with multiple sclerosis (MS) manage their fatigue. The trial will enroll 2,000 people across the US, with a focus on including groups often left out of research. Participants will either…

This study is testing whether a supervised, remote exercise program can reduce severe fatigue in young adults who have survived brain cancer. Researchers will enroll 75 survivors aged 18-39 who are struggling with fatigue and are less than five years out from treatment. The goal …

This study is testing whether combining education and counseling with a placebo pill works better than education alone to reduce fatigue in people with advanced cancer. Researchers want to see if this combination improves quality of life, mood, sleep, and thinking for 240 patient…

This study is testing whether a non-invasive brain stimulation treatment can help people with Long COVID who experience persistent fatigue, brain fog, and mood changes. Researchers will compare the real treatment to a placebo in 102 participants to see if it reduces their fatigue…

This study is testing a new wellness program designed to help adults with cystic fibrosis who struggle with severe fatigue and poor sleep. The program combines virtual coaching sessions with strategies to improve sleep and increase physical activity. Researchers will enroll 80 pa…

This study is testing whether special 'dynamic' lighting in hospital rooms can help improve sleep and daily rhythms for elderly patients. It will involve 300 patients over age 65 who are hospitalized. Researchers will compare patients in rooms with the special lighting to those i…

This study is testing whether a specific nutritional supplement, called APPORTAL®, can help reduce severe fatigue in people with breast cancer who are undergoing chemotherapy. Researchers will enroll 92 female participants who are experiencing moderate to severe fatigue. They wil…

This study is testing whether a walking program can help reduce severe fatigue in older women who have finished breast cancer treatment. Researchers will compare a supervised group walking program to a home-based walking plan over 8 weeks. The goal is to see if regular walking ca…

This study is testing whether a non-invasive brain stimulation technique can reduce the severe fatigue commonly experienced by people with multiple sclerosis (MS). Researchers will use a device called repetitive Transcranial Magnetic Stimulation (rTMS) to deliver magnetic pulses …

This study aims to train therapists to provide personalized mental health therapies to cancer patients and their caregivers who are experiencing significant distress, anxiety, depression, or sleep problems. About 100 patients and caregivers in Massachusetts will receive therapy s…

This study is testing whether a specific, long-term exercise program can help U.S. veterans feel better. It will see if the workouts improve body composition, physical strength, and reduce symptoms of pain, fatigue, depression, and PTSD. Over 18 months, 25 participants will atten…

This study is testing whether a dietary supplement called fisetin can help reduce persistent fatigue in older adults who have survived cancer. It will involve 60 participants aged 65 and over who report significant tiredness. In this carefully designed trial, participants will ta…

This study is testing if a medication called modafinil can help reduce severe fatigue and thinking problems (often called 'chemo brain') in people with advanced cancer. About 40 patients will take either the drug or a placebo pill for one week to see if it makes a difference. The…

This study aims to understand why people with Long COVID experience severe fatigue and brain fog. Researchers will use brain scans and grip strength tests to compare 200 people with Long COVID to healthy individuals. The goal is to learn how the brain processes effort and fatigue…

This study aims to understand if there is a link between how well you sleep and the severity of gum disease (periodontitis). Researchers will examine 48 participants, checking their gum health, having them fill out sleep and fatigue questionnaires, and testing their saliva for ce…

This study aims to understand why people with severe spondyloarthritis experience such extreme fatigue and how it relates to actual muscle function. Researchers will follow 122 patients who are starting a new targeted therapy, measuring their exercise capacity, muscle strength, a…

This study aims to understand how common sexual dysfunction is in women living with multiple sclerosis (MS). Researchers will enroll 140 women with MS to complete surveys about their sexual health, fatigue, mood, and other symptoms. The goal is to identify connections between sex…

This study aims to understand how common and severe fatigue is for people after their first stroke. Researchers will observe 107 patients to see if fatigue levels are connected to other factors like mood, sleep, pain, and physical ability. The goal is to gather information that c…

This research study aims to understand how our brains decide when a task feels too hard or worth the effort, especially when we're tired. Researchers will use brain scans and simple choice games with 185 healthy adults to see which brain areas are involved. The goal is to build b…

This study aims to understand why some people experience severe fatigue and thinking problems after stem cell transplants. Researchers will examine 30 transplant survivors to see if brain inflammation might be causing these symptoms. They'll use brain scans and spinal fluid tests…

This study is testing whether smartphone recordings can help measure key symptoms of myasthenia gravis, a rare autoimmune disease that causes muscle weakness. Researchers will use video and audio from participants' phones to track symptoms like speech changes, eyelid drooping, an…

This study aims to better understand the different types and causes of fatigue, which is a common symptom in many conditions like cancer, lupus, and chronic fatigue syndrome. Researchers will enroll about 700 adults, both with and without fatigue, to complete questionnaires, phys…

This study aims to understand how cancer survivors experience and talk about the fatigue that often lingers after treatment. Researchers will interview 80 survivors and their doctors to learn the words and descriptions they use. The goal is to create a visual poster to help patie…