FATIGUE

This study tests whether testosterone replacement can ease fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. About 230 participants will receive either testosterone or a placebo for several months. The goal is to see if this treatm…

This study tests whether walking exercise can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment within the past year will take part. They will either walk at a center or at home for 12 weeks. The goal is to see if…

This study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can reduce fatigue in people with multiple sclerosis (MS). Sixty participants will receive either real or sham (fake) rTMS for 30 minutes daily for five …

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study tests whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, anxiety, depression, fatigue, and inflammation in 276 participants over 20 weeks. The goal is to see if a si…

This study tests if a safe, gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 adults who are at least 3 months past their first stroke and have significant fatigue. Participants will use a headset devi…

This study looks at whether using a simple stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will be asked to squeeze a stress ball while getting their treatment. The goal is to see if this easy, drug-free …

This study looks at whether a simple strength-training program can help breast cancer survivors manage fatigue. Researchers will work with 60 women from different income levels to see who sticks with the program and why. The goal is to make exercise support fair and accessible fo…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in people with advanced cancer. About 188 participants will be randomly assigned to recei…

This study tests whether aerobic exercise or cognitive behavioral therapy can reduce severe fatigue in people with myasthenia gravis, a muscle weakness disease. Researchers will compare these approaches to usual care in 60 adults with stable MG. The goal is to find practical ways…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists learn to use proven methods like cognitive behavioral therapy and mindfulness to help with anxiety, depression, pain, fatigue, …

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. Fatigue is a common and disabling symptom after stroke. The trial will enroll 60 participants and measure changes in fa…

This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other symptoms in people with post-COVID syndrome. About 40 adults with long COVID and chronic tiredness will receive the treatment. The main goal is to see …

This study tests the safety of Niagen Plus, an injectable form of vitamin B3, in 40 generally healthy adults with fatigue. Participants receive injections under the skin or into muscle over 100 days, and researchers monitor side effects, NAD+ levels, and changes in fatigue, sleep…

This study looks at whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take part. Researchers will measure muscl…

This study tests two online programs designed to help people with multiple sclerosis (MS) manage their fatigue. Researchers will enroll 2,000 adults with MS across the U.S. to see if these programs, added to usual care, reduce tiredness better than usual care alone. The study las…

This study tests whether a supplement made from seaweed, called fucoidan, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study tests whether taking a supplement called fisetin can help reduce fatigue in older adults who have survived cancer. Researchers will measure changes in fatigue levels using a standard questionnaire. The study aims to enroll 60 participants.

This study tests whether a special nutrient supplement (APPORTAL®) can help reduce severe tiredness in women with breast cancer who are on chemotherapy. About 92 participants will take either the supplement or a placebo for 8 weeks, along with recommended exercise. Researchers wi…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (65+) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to find a simple, non-dru…

This study looks at whether exercise therapy and cognitive behavioral therapy (a type of talk therapy) can help reduce fatigue in women with breast cancer. About 100 female patients in Singapore will take part. The goal is to see if these treatments are acceptable, culturally sen…

This study tests a new treatment called transcranial pulse stimulation (TPS) for people with Post-COVID syndrome who suffer from fatigue, memory problems, or mood changes. TPS uses gentle sound waves to stimulate the brain. Half of the 102 participants will get real TPS, and the …

This study tests a wellness program for adults with cystic fibrosis who feel very tired. The program includes coaching sessions to help improve fatigue, sleep, and physical activity. Researchers will see if people stick with the program and if it helps them feel better compared t…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study aims to see if combining psychoeducational interventions (like counseling and self-help strategies) with an open-label placebo pill can better improve fatigue and quality of life in people with advanced metastatic cancer than either approach alone. About 240 adults wit…

This study tests whether a weak electrical current applied to the neck or upper back can change how muscles work and how tired they get. Healthy adults aged 18 to 50 will attend up to 6 sessions to measure muscle force, effort, and activation. The goal is to understand the effect…

This study looks at why people with Long COVID (PASC) feel so tired. Researchers will use brain scans and simple grip-strength tasks to measure effort and fatigue. The goal is to understand the brain's role in fatigue, not to test a treatment. About 200 adults with Long COVID and…

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…

This study looks at why some people who have had a stem cell transplant continue to feel extremely tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand t…

This study looks at how fatigue and muscle function are connected in people with axial spondyloarthritis, a type of inflammatory arthritis. Researchers will measure exercise capacity and muscle strength in 122 adults starting a new targeted therapy. The goal is to better understa…

This study aims to understand the different types of fatigue people experience, especially those with conditions like cancer, lupus, and chronic fatigue syndrome. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optio…

This study aims to understand what causes fatigue in people with Sjögren's disease. About 100 adults will complete surveys and pain tests at the start and again after 3 months. No new treatments are given; the goal is to gather information to help future care.

This study will collect smartphone recordings from 225 people with and without myasthenia gravis to measure symptoms like slurred speech, hoarse voice, droopy eyelids, and arm fatigue. Researchers will use machine learning to see if these recordings can tell the difference betwee…

This study aims to understand how the brain decides how much effort to put into tasks, and how fatigue and rewards change that decision. Researchers will use brain scans and choice tasks in 185 healthy adults aged 18-35. The goal is to map the brain circuits behind mental and phy…

This study looks at how often sexual problems occur in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. About 140 women with relapsing-remitting MS will fill out questionnaires and take simple tests. T…

This study looks at whether a type of talking therapy (transdiagnostic cognitive behavioral therapy) can help reduce fatigue in primary care patients. About 190 adults aged 18-67 with severe fatigue lasting at least 3 months will be randomly assigned to either the therapy or usua…

This study looks at the best ways to help people with physical disabilities stay active using home exercise videos and health coaching. Over 32 weeks, 257 participants will try different support options, like one-on-one coaching or group classes, based on how well they are doing.…

This study looks at how often fatigue occurs after a first stroke and what factors—like pain, mood, sleep, or physical ability—might make it worse. About 107 adults who had a stroke at least three months ago will answer questionnaires and do simple tests. The goal is to help doct…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates between MS patients with and without low antibody levels. The goal is to und…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…