FATIGUE

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This study looked at whether giving liver transplant patients simple exercise guides—either a brochure or a video—could help them be more active, feel less tired, and reduce the burden on their caregivers. Over 100 adults who had a liver transplant were split into three groups: o…

This study investigates whether dynamic tape—a stretchy, elastic tape—can improve shoulder strength, delay fatigue, and enhance muscle control in recreational overhead athletes (like tennis players or swimmers). Participants will receive dynamic tape, kinesio tape, or a sham tape…

This Phase 3 trial tested whether Nuvastatic, a plant extract, can reduce cancer-related fatigue in 180 women with breast cancer undergoing chemotherapy. Participants took Nuvastatic or a placebo three times daily for three chemo cycles. The study measured fatigue levels and qual…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study tested a program called RESET, led by community health workers, to improve physical and mental well-being in older adults. Over 450 African American adults aged 50+ with symptoms like depression, anxiety, or chronic pain took part. The program included weekly group pho…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study tested if hand reflexology massage could reduce fatigue and anxiety in adults with end-stage kidney disease who are on maintenance hemodialysis. 70 patients were split into two groups: one received eight 21-minute hand massage sessions during dialysis over four weeks, …

This study tested whether a short virtual reality session could help reduce pain and fatigue in patients who just had a liver transplant. 84 patients were split into two groups: one got a 20-minute VR experience, the other got standard care. Researchers measured pain, fatigue, an…

This study tested whether MitoQ, a dietary supplement, can reduce fatigue in people with multiple sclerosis. 45 participants took either 20 mg, 40 mg, or a placebo daily for 12 weeks. Researchers measured changes in fatigue using a standard survey. The goal is to find a safe, sim…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tested whether foot reflexology massage could help people with epilepsy. 70 patients received reflexology sessions, and researchers measured changes in seizure frequency, fatigue, stress, and sleep quality. The goal was to see if this gentle foot massage could improve …

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested whether a noninvasive device that stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help young athletes recover more quickly after sports activity. Forty healthy amateur football players aged 18-25 participated. The researchers measured …

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants used either bright-white or dim-red light boxes at different times of day. The goal was to find the most effective dose to ease slee…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study looked at whether a gentle exercise program called Gyrokinesis could help reduce cancer-related fatigue in children and teens who had been treated for a brain tumor. 80 participants who had finished active treatment at least a year earlier took part. The study measured…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested a low-cost, portable exercise program for people with non-small cell lung cancer after surgery. The goal was to help them manage severe fatigue and improve their quality of life. 235 adults took part, and the program was designed to be safe and practical for nea…

This study tested whether taking a daily probiotic supplement for three months could reduce fatigue and stress in professional dancers. Researchers measured changes in gut bacteria, immune markers, and stress-related chemicals in the blood. The goal was to see if probiotics could…

This study looked at whether watching exercise videos before doing the exercises helps older adults improve their thinking, balance, tiredness, and physical abilities. 162 people aged 65 and older took part. Some did regular exercises, some watched videos of the exercises first, …

This study tested whether acupressure, a technique from Traditional Chinese Medicine, can ease fatigue in ovarian cancer survivors. 171 women who had completed primary cancer treatment were taught to apply pressure to specific points on their bodies daily for six weeks. The study…

This study tested whether wearing virtual reality glasses to visit a museum during chemotherapy could help reduce pain, fatigue, and anxiety. 64 patients were split into two groups: one received routine care, while the other also took a 20-minute virtual museum tour each week for…

This study looked at whether music therapy can help reduce fatigue and improve certain blood test results in people with acute myeloid leukemia who are going through chemotherapy for the first time. Sixty adults took part, and researchers measured their fatigue levels and lab val…

This study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…

This study tested whether laughter yoga—a practice combining laughing exercises and breathing techniques—can reduce fatigue, improve sleep quality, and boost psychological well-being in people with multiple sclerosis. Forty MS patients participated, with one group doing laughter …

This study looked at whether kinesiological taping (a special tape applied to the skin) or foot massage can help women who had a C-section feel less pain, tiredness, and mood problems. 97 new mothers were split into three groups: one got taping, one got foot massage, and one got …

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and to gather data for a l…

This study tested whether a dietary supplement called Radicle Revive can improve stress, sleep, and menopause-related issues in 500 perimenopausal women aged 40 and older. Participants took either the active supplement or a placebo for 6 weeks. The trial is complete, but results …

This completed study tested two dietary supplements designed to boost energy and reduce fatigue. Over 500 adults in the U.S. took either an active supplement or a placebo for six weeks. Researchers measured changes in fatigue, cognitive function, and sleep using standard question…

This study looked at whether smelling geranium essential oil can help reduce tiredness and improve sleep in people receiving dialysis for kidney failure. 90 adults on dialysis took part in a crossover trial where they received both the aromatherapy and a placebo at different time…

This study looked at whether three types of cognitive behavioral therapy (CBT) delivered online could help reduce fatigue in people with multiple sclerosis. 21 adults with MS and chronic fatigue tried relaxation training, behavioral activation, or cognitive therapy. The goal was …

This study tested whether listening to live music, hearing a ney flute, or interacting with a robotic parrot could help people on dialysis feel less anxious and less tired. 64 adults on regular hemodialysis took part. Researchers measured their anxiety and fatigue levels before, …

This study looked at whether starting a personalized exercise program before breast cancer surgery helps women recover better. Thirty female survivors followed the program for 12 months. The goal was to improve shoulder motion, reduce pain, and enhance daily function and quality …

This completed study tested whether a dietary supplement called Radicle Energy™ 25_SR.1 could help reduce fatigue. About 500 adults took either the supplement or a placebo for 6 weeks. Researchers measured changes in fatigue, thinking ability, and sleep quality using standard que…

This pilot study tested whether muscadine grape extract can improve fatigue in people aged 70 and older who have had cancer. 64 participants took either the grape extract or a placebo for 12 weeks. The study measured changes in fatigue and physical function using questionnaires.

This study tested an 8-week tele-rehabilitative exercise program for nurses with long COVID. The program included aerobic and strengthening exercises done at home using a wearable knee brace and a smartphone app. Researchers measured changes in fatigue, heart and lung fitness, lo…

This completed study tested two dietary supplements against a placebo in 750 adults with fatigue. Participants took the product daily for 6 weeks, and researchers measured changes in fatigue, cognitive function, and sleep. The goal was to see if these supplements could help peopl…

This completed study tested three dietary supplements against a placebo to see if they could reduce fatigue in 1,000 adults. Participants took the products for 6 weeks and reported changes in tiredness, cognitive function, and sleep. The study was double-blind, meaning neither pa…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study tested whether a supervised exercise program (MoveUS) could reduce fatigue and improve quality of life in 108 adults with shoulder instability. Participants were randomly assigned to either the exercise program or usual care. The results will help determine if this app…

This study tested a blood filtering procedure called immunoadsorption to see if it reduces fatigue in people with post-COVID syndrome. 63 patients received either the real procedure or a sham version over 14 days. The goal was to measure changes in fatigue and other symptoms like…

This study tested two non-drug techniques—therapeutic touch and emotional freedom technique (tapping)—on 60 new mothers who had vaginal births. Over six weeks, one group received touch therapy, another did tapping, and a third got standard support. Researchers measured mood and f…

This study looked at how doing a mental task while exercising affects muscle fatigue in healthy adults aged 18-35 and 65-90. Researchers measured changes in arm strength, anxiety, blood pressure, and fatigue using questionnaires and a custom device. The goal was to understand the…

This study looked at whether listening to self-selected music during warm-up helps futsal players perform better in short, intense exercise tests during and after Ramadan fasting. Ten highly trained male players completed sprint tests with and without music. The goal was to see i…

This completed study looked at how apathy (lack of motivation) influences different forms of fatigue in 57 older adults with mild cognitive disorders. Participants wore an activity tracker for a week and completed tests like a 6-minute walk and questionnaires. The goal was to com…

This study looked at whether chemicals in saliva can show when a driver is dangerously sleepy. Over 500 drivers stopped by police in Belgium gave a saliva sample and reported their sleepiness level. Researchers hope to find a biological marker that could one day be used to preven…

This completed study looked at 129 people with Parkinson's disease to understand what factors are linked to fatigue. Researchers measured fatigue, sleep, mood, and physical function using questionnaires and a walking test. The goal was to identify which aspects of Parkinson's mos…

This completed study tested a new way to measure physical fatigue in 40 people — stroke survivors and older adults with muscle loss. Participants performed everyday tasks like walking stairs and crouching while researchers tracked their perceived effort, heart rate, and muscle ac…

This study aimed to uncover what factors most affect functional capacity—like walking, standing, and daily tasks—in people with fibromyalgia. Researchers assessed 42 adults using physical tests, pain and fatigue scales, posture analysis, sleep quality, and psychological questionn…

This study looked at whether a 25-minute or 45-minute nap helps teenage soccer players run faster and feel less tired. Sixteen male players tried both nap lengths and a no-nap day. Results showed that napping improved agility and made exercise feel easier, but did not help them k…

This study looks at how cardiac arrest affects thinking, memory, emotions, and sleep over time. About 200 survivors will take detailed brain tests 7 and 24 months after their cardiac arrest. Their results will be compared to heart attack patients who did not have a cardiac arrest…

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …

This completed study looked at 94 older adults to compare how prediabetes and type 2 diabetes affect cognitive status, physical function, and fatigue. Participants were grouped by their HbA1c levels (healthy, prediabetic, or diabetic) and tested with tools like the Montreal Cogni…

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could reduce fatigue, pain, depression, sleep problems, and stress in women who finished treatment for early-stage breast cancer 1-2 years earlier. Researchers enrolled 98 women an…

This study looked at how a dose of caffeine (6mg per kg of body weight) affects the way healthy adults perform exercises like running, squatting, and jumping, both when fresh and when tired. Researchers measured angles, forces, and timing to see if caffeine changes movement techn…