Exercise program tested to keep colon cancer at bay

NCT ID NCT00819208

Completed Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus health education or health education alone. The main goal was to see if exercise improved disease-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: physical activity program
What this could lead to: If successful, this could show that a structured exercise program helps prevent colon cancer from coming back and improves survival.
What could go wrong: This is a completed trial, but the results may not show a clear benefit. Exercise adherence can vary, and the effect on cancer recurrence is uncertain.

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Conditions

The condition(s) this trial relates to.

anxiety disorder colon adenocarcinoma colonic neoplasm colorectal cancer colorectal neoplasm Depression depressive disorder Fatigue sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DISORDER COGNITIVE/FUNCTIONAL EFFECTS COLORECTAL CANCER DEPRESSION EXCERCISE FATIGUE PSYCHOSOCIAL EFFECTS OF CANCER AND ITS TREATMENT SLEEP DISORDERS

Contacts and locations

Locations

Study site

Lévis, Quebec, G6V 3Z1, Canada
Study site

Montpellier, CEDEX 5, France
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
Armidale Hospital

Armidale, New South Wales, 2350, Australia
BCCA - Vancouver Cancer Centre

Vancouver, British Columbia, V5Z 4E6, Canada
Bankstown-Lidcombe Hospital

Bankstown, New South Wales, 2200, Australia
Belfast City Hospital

Belfast, Co. Antrim, BT9 7AB, United Kingdom
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Concord Repatriation General Hospital

Concord, New South Wales, 2139, Australia
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Dartmouth-Hitchcock

Lebanon, New Hampshire, 03756, United States
Exercise Medicine Center for Diabetes and Cancer

Seoul, South Korea
Flinders Medical Centre

Bedford Park, South Australia, 5042, Australia
Grand River Regional Cancer Centre

Kitchener, Ontario, N2G 1G3, Canada
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Horizon Health Network

Fredericton, New Brunswick, E3B 5N5, Canada
Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
Liverpool Hospital

Liverpool, New South Wales, 2170, Australia
London Regional Cancer Program

London, Ontario, N6A 5W9, Canada
Macarthur Cancer Therapy Centre - Campbelltown Hospital

Campbelltown, 2560, Australia
Newcastle Private Hospital

Newcastle, New South Wales, 2305, Australia
Niagara Health System

St. Catharines, Ontario, L2S 0A9, Canada
North Coast Cancer Institute - Port Macquarie

Port Macquarie, New South Wales, 2444, Australia
North Coast Cancer Institute Coffs Harbour

Coffs Harbour, New South Wales, 2450, Australia
Odette Cancer Centre

Toronto, Ontario, M4N 3M5, Canada
Ottawa Hospital Research Institute

Ottawa, Ontario, K1H 8L6, Canada
Princess Alexandra

Woolloongabba, Queensland, 4102, Australia
Regional Health Authority B, Zone 2

Saint John, New Brunswick, E2L 4L2, Canada
Riverina Cancer Care Centre

Wagga Wagga, New South Wales, 2650, Australia
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Royal Brisbane and Women's Hospital

Herston, Queensland, 4029, Australia
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
Royal Perth Hospital

Perth, Western Australia, 6000, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Sinai Health System

Toronto, Ontario, M5G 1X5, Canada
St Vincent's Hospital Melbourne

Fitzroy, Victoria, 3065, Australia
Stronach Regional Health Centre at Southlake

Newmarket, Ontario, L3Y 2P9, Canada
Sydney Adventist Hospital

Wahroonga, New South Wales, 2076, Australia
Tamworth Hospital

Tamworth, New South Wales, 2340, Australia
The Moncton Hospital

Moncton, New Brunswick, E1C 6Z8, Canada
The Queen Elizabeth Hospital

Woodville, South Australia, 5011, Australia
Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada
Toronto Rehab

Toronto, Ontario, M4G 1R7, Canada
Trillium Health Partners - Credit Valley Hospital

Mississauga, Ontario, L5M 2N1, Canada
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599-1651, United States

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