ANXIETY DISORDER

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests a modified version of dialectical behavior therapy (DBT) for people with anxiety or depressive disorders. Researchers will enroll 250 adults across two medical centers and randomly assign them to receive the adapted DBT or standard care. The goal is to see if thi…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study is testing a behavioral therapy called 'Being Brave' to help reduce anxiety in autistic children aged 3 to 6. The therapy involves 16 weekly sessions with parents and children, using visual aids and practice exercises. Researchers will also look at biological markers t…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study is testing whether hyperbaric oxygen therapy (HBOT) can improve thinking, mood, and quality of life in veterans who have traumatic brain injury, PTSD, anxiety, or depression. Fifty-four veterans will receive multiple HBOT sessions in a pressurized chamber while breathi…

This study tests a 10-session group therapy designed to help teens aged 15-18 with autism who also have anxiety or depression. The therapy focuses on changing how they think about their own thoughts. Researchers want to see if the therapy is practical, acceptable, and shows promi…

This study is testing a therapy program called the Unified Protocol for Children (UP-C) and Adolescents (UP-A) to help young people aged 7-17 with anxiety, depression, or other emotional difficulties. The program involves up to 24 sessions with a therapist, either in groups or in…

This study is testing whether a single low dose of esketamine, given during a colonoscopy, can reduce symptoms of irritable bowel syndrome (IBS) in adults who also have anxiety or depression. The trial plans to enroll 552 participants and will measure symptom severity and quality…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…