Could a common supplement fight fatigue in progressive MS?
NCT ID NCT02804594
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial tests whether N-acetyl cysteine (NAC), an antioxidant supplement, can reduce fatigue in people with progressive multiple sclerosis. Participants take NAC or a placebo three times daily for four weeks, and researchers measure changes in fatigue scores and brain chemistry. The study aims to see if NAC is safe and effective for this hard-to-treat symptom.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- N-acetyl cysteine (NAC), 1250 mg three times daily
- What this could lead to
- If NAC reduces fatigue, it could offer a new, well-tolerated option for managing a common and disabling symptom in progressive MS.
- What could go wrong
- This is a small, short (4-week) early-phase trial. Fatigue is subjective and may not improve, and NAC can cause side effects like nausea or headache.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California San Francisco
San Francisco, California, 94158, United States
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