Could a simple injection replace an IV for MS treatment?
NCT ID NCT05232825
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study is testing whether a subcutaneous (under the skin) injection of ocrelizumab works as well as the standard intravenous (IV) infusion for people with relapsing or primary progressive multiple sclerosis. The trial will compare how the drug is absorbed, its safety, and its effects on the disease, including brain lesions seen on MRI. Participants will receive either the injection or the infusion, along with pre-medications to reduce infusion reactions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ocrelizumab
- What this could lead to
- If the injection works as well as the infusion, it could offer people with MS a more convenient way to receive this treatment, potentially improving quality of life.
- What could go wrong
- The injection might not deliver the drug as effectively as the infusion, or it could cause different side effects. The trial is still in progress, so results are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Azienda Ospedaliera Sant'Andrea
Rome, Lazio, 00189, Italy
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Bakirkoy State Mental Hospital
Istanbul, 34000, Turkey (Türkiye)
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CEDOES - Diagnóstico e Pesquisa
Vitória, Espírito Santo, 29055-450, Brazil
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Care Clinic
Katowice, 40-568, Poland
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Centrum Neurologii Krzysztof Selmaj
Lodz, 90-324, Poland
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Charles University, Medical faculty, Hradec Kralove
Hradec Králové, 500 05, Czechia
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Clinica Amo Assistencia Medica Em Oncologia
Salvador, Estado de Bahia, 41950640, Brazil
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Complejo Hospitalario Nuestra Señora de la Candelaria
Santa Cruz de Tenerife, Tenerife, 38010, Spain
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Fakultni nemocnice Motol
Prague, 150 06, Czechia
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Fakultni nemocnice Ostrava
Ostrava-Poruba, 708 52, Czechia
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Fakultni nemocnice u sv. Anny
Brno, 656 91, Czechia
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Fakultni poliklinika VFN
Prague, 128 08, Czechia
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Hawkes Bay Hospital
Hastings, 4120, New Zealand
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14011, Spain
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Hospital Universitario Virgen Macarena
Seville, Sevilla, 41071, Spain
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IRCCS Istituto Neurologico Neuromed
Pozzilli, Molise, 86077, Italy
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Istanbul Universitesi - Cerrahpasa Cerrahpasa Tip Fakultesi
Istanbul, 34098, Turkey (Türkiye)
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Katip Celebi University Ataturk Training and Research Hospital
Izmir, 35360, Turkey (Türkiye)
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Kocaeli University Hospital
Kocaeli, 41380, Turkey (Türkiye)
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Krajska zdravotni a.s Nemocnice Teplice o.z.
Teplice, 415 01, Czechia
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Memorial Healthcare Institute for Neurosciences and Multiple Sclerosis
Owosso, Michigan, 48867, United States
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Namik Kemal Universitesi Sagli Uygulama ve Arastirma Hastanesi
Süleymanpa?a, 59100, Turkey (Türkiye)
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Nemocnice Jihlava
Jihlava, 58633, Czechia
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Neurocentrum Bydgoszcz sp. z o.o
Bydgoszcz, 85-796, Poland
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Neurology Associates PA
Maitland, Florida, 32751, United States
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Neurology Clinic PC
Cordova, Tennessee, 38018, United States
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Optimal Clinical Trials
Auckland, 1010, New Zealand
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Ospedale Civile di Montichiari
Montichiari, Lombardy, 25018, Italy
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Pardubicka Krajska Nemocnice
Pardubice, 532 03, Czechia
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Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla
Rome, Lazio, 00133, Italy
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Premier Neurology
Greenville, South Carolina, 29605, United States
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Przychodnia EuroMediCare
Wroc?aw, 50-220, Poland
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UC Health Neurology
Dayton, Ohio, 45417, United States
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University of South Florida
Tampa, Florida, 33612, United States
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