Can blood filtering beat long COVID fatigue?

NCT ID NCT05954325

Completed Symptom relief Sponsor: Hannover Medical School Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a blood filtering procedure called immunoadsorption to see if it reduces fatigue in people with post-COVID syndrome. 63 patients received either the real procedure or a sham version over 14 days. The goal was to measure changes in fatigue and other symptoms like brain fog and post-exertional malaise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Immunoadsorption (blood filtering procedure)
What this could lead to: If it works, this could point toward a treatment for chronic fatigue in post-COVID syndrome.
What could go wrong: This is a small, early-stage study with no phase. The sham control means the real effect may be small or absent. Risks include discomfort or complications from the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fatigue long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FATIGUE POST-ACUTE COVID-19 SYNDROME

Contacts and locations

Locations

Hannover Medical School

Hanover, Lower Saxony, 30625, Germany

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