FATIGUE

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This trial tests whether taking a daily capsule of Nepalese pepper extract (Zanthoxylum armatum) for 42 days can improve cognitive speed, reduce mental fatigue, and enhance gaming performance in healthy young action video gamers aged 16 to 39. Participants will take either the pe…

This trial tests a 12-week, physiotherapist-led online exercise program called POSH-Ex for women who recently gave birth. The program combines pelvic floor training, breathing exercises, and whole-body movements to improve sexual function and overall well-being. Researchers will …

This study tests whether two dietary supplements can help reduce fatigue in adults aged 40 and older. Participants take the supplement or a placebo for 8 weeks, and researchers track changes in fatigue, sleep quality, and cognitive function. The goal is to see if these products o…

This study tests whether a dietary supplement can reduce fatigue and improve sleep in women aged 21 to 60. Participants take either the active supplement or a placebo for 8 weeks, and researchers track changes in fatigue and sleep quality. The trial is double-blind and placebo-co…

This trial tests an 8-week eHealth program called eMindExCare that combines mindfulness practices with home-based aerobic and resistance exercises for prostate cancer patients undergoing active treatment. The study aims to see if the program is feasible and acceptable, and whethe…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve quality of life, reduce fatigue, and clear brain fog in people with long COVID. Twenty adults with persistent fatigue or cognitive problem…

This study tests whether a 16-week personalized home exercise program can improve muscle health and reduce fatigue in adults with stable lupus. Participants do three weekly sessions combining high-intensity interval training, strength exercises, and walking. Researchers measure c…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests whether a dietary supplement called Redsenol-1 Plus can safely reduce fatigue in adults who have had cancer treatment. 72 participants will take either the supplement or a placebo for 12 weeks. The main goal is to see if fatigue levels improve, as measured by a s…

This study tests whether a dietary supplement called Radicle Energy VBM can help reduce fatigue and improve cognitive function, mental health, and sleep. Over 6 weeks, 550 adults will take either the active supplement or a placebo, without knowing which they received. The goal is…

This study tests whether walking with a robot dog can improve sleep, reduce fatigue, and enhance quality of life in children aged 2-7 who are undergoing cancer treatment. Forty children will be randomly assigned to either robot-dog-assisted walks or usual care. The goal is to see…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests whether doing art activities (like drawing or painting) can reduce fatigue, anxiety, and improve quality of life in adults with blood cancers. Fifty-two patients will be split into two groups: one gets six art sessions over two weeks, the other gets standard care…

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study tests whether personalized lifestyle coaching can help emergency medicine residents stay alert and recover better during night shifts. Thirty residents will either receive one-on-one coaching or just a handout on sleep and nutrition. Researchers will track sleep, react…

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study tests whether inhaling agarwood essential oil while sleeping can reduce fatigue and improve sleep quality in hospital staff. About 78 participants will use either an agarwood sachet or a placebo (almond oil) near their bed for one week. Researchers will measure changes…

This study looks at how a basketball-style interval workout affects metabolism, inflammation, and fatigue in female basketball players aged 16 to 22. Participants will do a standardized shuttle-run test designed to mimic game demands, with blood samples and reaction-time checks t…

This study looks at whether the fatigue from a simulated taekwondo match changes how well female athletes keep their balance. About 20 competitive female taekwondo athletes, aged 18-20, will do a three-round match-like exercise and have their static and dynamic balance tested bef…

This study looks at how repetitive overhead movements, like volleyball spikes, affect shoulder mechanics and structures when muscles are tired. Healthy recreational volleyball players perform a fatigue protocol using Thera-band exercises, and researchers measure joint angles, mus…

This study follows 100 new nurses over time, using non-invasive sleep monitors and questionnaires to track sleep quality, stress, and burnout. Researchers will use AI to see if sleep data can predict which nurses are at risk of burnout or leaving their jobs. No treatments are giv…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study looks at how sarcopenia (age-related muscle loss) is connected to fatigue and orthostatic intolerance (dizziness when standing up) in people aged 65 and older. Researchers will compare 90 older adults with and without sarcopenia to see if those with muscle loss experie…

This pilot study will use brain scans (fMRI) to understand how transcutaneous electrical nerve stimulation (TENS) affects brain activity in 30 people with multiple sclerosis (MS). TENS is a safe, home-use device that sends mild electrical pulses through the skin. The goal is to l…