FATIGUE

This early-stage study tests whether a non-invasive brain stimulation technique called rTMS is safe and tolerable for treating depression and fatigue in adults with multiple sclerosis (MS). About 20 participants with MS and moderate-to-severe depression will receive daily rTMS se…

This study looks at whether art-based activities can help people with blood cancers feel less tired and anxious, and improve their quality of life. About 52 patients receiving chemotherapy will be split into two groups: one will take part in art sessions three times a week for tw…

This study tests two simple, drug-free methods—reflexology (foot massage) and progressive muscle relaxation—to see which better reduces fatigue in people on dialysis. Sixty adults aged 50-70 with moderate to severe fatigue will be split into three groups and followed for 12 weeks…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults will be split into two groups: one uses the app daily for 4 weeks, the other gets usual care. The goal is t…

This study aims to see if certain health and wellness products can help reduce fatigue in women going through menopause. About 550 women aged 35-60 who have at least two menopausal symptoms will take either the product or a placebo. The main goal is to measure changes in fatigue …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study tests whether a relaxation method called autogenic training can reduce restless leg syndrome, improve sleep, and lessen fatigue in people on hemodialysis. Fifty-four adults aged 45-55 who have been on dialysis for at least 6 months will practice structured relaxation s…

This study tests whether inhaling the scent of agarwood (a fragrant wood) during sleep can improve sleep quality and reduce fatigue in hospital staff. About 78 employees will use either an agarwood sachet or a placebo (almond oil) sachet near their bed for 7 nights. The goal is t…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This study looks at whether a supplement called Alpha Brain can improve thinking, alertness, and mood in healthy adults who haven't slept much. About 34 people will take the supplement or a placebo on different days and do tests. The goal is to see if it helps with focus and redu…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can ease a cluster of tough symptoms—pain, fatigue, trouble sleeping, anxiety, depression, and brain fog—in breast cancer survivors who are on hormone therapy. About 228 women will get e…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This early-phase study tests whether bupropion, a drug used for smoking cessation and depression, can reduce severe fatigue in 16 adults with end-stage kidney disease on hemodialysis. Participants take the pill three times a week during dialysis for 8 weeks and report their fatig…

This study tests a web-based program to help people with advanced cancer and their caregivers. The program aims to reduce symptoms like depression, pain, fatigue, and sleep problems in patients, and lower stress and depression in caregivers. About 40 patient-caregiver pairs will …

This study tests whether personalized coaching on sleep, exercise, and nutrition can help emergency medicine residents stay alert and recover better during overnight shifts. Thirty residents will be split into two groups: one gets one-on-one coaching before shifts, the other rece…

This study looks at how muscle loss (sarcopenia) relates to tiredness and dizziness when standing up in people aged 65 and older. Researchers will compare 90 older adults with and without muscle loss to see if those with weaker muscles feel more tired or dizzy. The goal is to hel…

This pilot study will use brain scans (fMRI) to see how a mild electrical stimulation treatment called TENS affects brain activity in 30 people with Multiple Sclerosis who have fatigue and walking problems. The goal is to understand how TENS works in the brain, not to test it as …

This study tests whether a structured program called 'Stay Awake, Stay Alive' can help college students reduce drowsy driving. 72 students will be split into two groups: one gets the new program, the other gets standard education. They'll attend 4 weekly sessions and complete sur…