Could a narcolepsy drug beat IBD fatigue?
NCT ID NCT07295834
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, but researchers will also measure changes in fatigue and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
modafinil
What this could lead to
If this works, it could point toward a new treatment for severe fatigue in people with inflammatory bowel disease.
What could go wrong
This is a small, early feasibility study, not a large confirmatory trial. It may not show clear benefit, and modafinil can cause side effects like headache or anxiety.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Guy's and St Thomas' NHS Foundation Trust
London, SE1 9RT, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Imperial College Healthcare NHS Trust
London, NW10 7NS, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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King's College Hospital NHS Foundation Trust
London, SE20 7XE, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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St Mark's Hospital
London, NW10 7NS, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••