Could a narcolepsy drug beat IBD fatigue?

NCT ID NCT07295834

Not yet recruiting Symptom relief Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, but researchers will also measure changes in fatigue and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: modafinil
What this could lead to: If this works, it could point toward a new treatment for severe fatigue in people with inflammatory bowel disease.
What could go wrong: This is a small, early feasibility study, not a large confirmatory trial. It may not show clear benefit, and modafinil can cause side effects like headache or anxiety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease Fatigue ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE (CD) FATIGUE ULCERATIVE COLITIS (UC)

Contacts and locations

Locations

Guy's and St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Imperial College Healthcare NHS Trust

London, NW10 7NS, United Kingdom
King's College Hospital NHS Foundation Trust

London, SE20 7XE, United Kingdom
St Mark's Hospital

London, NW10 7NS, United Kingdom

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