ULCERATIVE COLITIS (UC)

This study is testing whether adding a high-dose vitamin D supplement to standard treatment helps people with moderate ulcerative colitis. Sixty patients in Pakistan will take either vitamin D or a placebo along with their regular medicines for 12 weeks. Researchers will check if…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) stick to their medication schedules and manage their symptoms better. Researchers will compare 35 teens using the app—which includes medication reminders, symp…

This study is testing whether an investigational drug called HSK47388 can help control symptoms and reduce inflammation in adults with moderate to severe ulcerative colitis. Researchers will compare HSK47388 against a placebo in about 150 participants whose current treatments are…

This study is testing whether simple nutrition education can help children and teens with inflammatory bowel disease (IBD) eat fewer ultra-processed foods like chips, soda, and fast food. About 120 young patients will track their eating and receive either educational handouts or …

This study looks at how well two different drugs, ozanimod and azathioprine, work for people with ulcerative colitis who need steroids to manage their disease. Researchers will review the medical records of 150 patients in Japan to see which drug is better at helping patients ach…

This study is testing a new drug called BCD-261 for adults with moderate to severe ulcerative colitis who haven't gotten enough relief from standard treatments. About 198 participants will receive either the new drug at different doses or a placebo to see which works better at ca…

This study is testing a new drug called XmAb942 to see if it is safe and can help control ulcerative colitis (UC). The first part checks safety in healthy people, and the second part tests if the drug reduces disease activity in people with moderate-to-severe UC. Participants wit…

This study is testing a new drug called OD-07656 for people with moderate to severe ulcerative colitis. The main goals are to see if it is safe and if it can reduce symptoms like bleeding and diarrhea. Researchers also want to find out if taking OD-07656 first makes a standard tr…

This study looks back at the medical records of 150 adults with moderate-to-severe ulcerative colitis (UC) to see which treatment approach worked better in real life. It compares patients who took a pill called upadacitinib by itself to those who took that same pill along with an…

This study is testing if adding a common allergy medicine, desloratadine, to standard ulcerative colitis treatment helps patients feel better. It will involve 44 adults with mild-to-moderate disease who are already taking mesalamine. Researchers want to see if the drug reduces gu…

This large observational study follows 4,000 patients who received fecal microbiota transplantation (FMT) to treat various gut conditions and autism. Researchers will track how well the treatment works and monitor safety over 1 to 5 years after the procedure. The goal is to under…

This study is testing if starting treatment with a newer injectable biologic drug (mirikizumab) right away leads to better long-term disease control for people newly diagnosed with moderate-to-severe ulcerative colitis. It compares this 'top-down' approach to the current standard…

This study aims to find out if people with ulcerative colitis who are in deep remission can safely reduce or stop their medication without the disease coming back. Researchers will follow 200 patients for two years, comparing those who continue their usual treatment to those who …

This study is testing if a medication called guselkumab can help people with Crohn's disease or ulcerative colitis who still have active symptoms despite taking ustekinumab. About 200 adults in Canada will switch to guselkumab and be monitored for one year to see if their symptom…

This study aims to test the safety and effectiveness of several new experimental drugs for adults with moderate-to-severe Crohn's disease or ulcerative colitis. It will enroll 140 participants to see if these treatments can reduce gut inflammation and control symptoms. The trial …

This study is testing whether patients with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce the frequency of their ustekinumab injections. Researchers want to see if patients can space out their shots from every 4 weeks to every 8 weeks, or from …

This study aims to help patients with ulcerative colitis decide between two main options when standard medications have failed. It will compare the quality of life for 500 people who either try additional drug therapies or choose to have their colon surgically removed. The goal i…

This study is testing whether following a specific diet plan, called the Crohn's Disease Exclusion Diet (CDED), can make standard biologic medications more effective for people with active Crohn's disease or ulcerative colitis. It will compare two groups of about 80 adults: one g…

This study is observing how well the medication Zymfentra works for people with Crohn's disease or ulcerative colitis in real-world settings. About 200 adult patients who are already prescribed Zymfentra as part of their regular care will complete online surveys about their sympt…

This study aims to see if a simpler, portable ultrasound scan can be as useful as a colonoscopy for monitoring ulcerative colitis and Crohn's disease, while also having a much smaller environmental footprint. Researchers will compare the two methods in 200 patients to measure bot…

This is a very early, first-in-human study to check the basic safety of a new drug called ALTB-268, which is being developed for ulcerative colitis. It will be given as a single intravenous dose to 24 healthy volunteers to see how their bodies react to it and process it. The main…

This study is creating a large national registry to track inflammatory bowel disease (IBD) patients in Germany over time. It aims to understand how patients are treated in everyday practice, how well treatments work, and how the disease affects quality of life. The goal is to gat…

This study aims to understand how the community of bacteria in our gut (the microbiota) influences the energy levels of our immune cells, particularly in people with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers will compare 45 healthy…

This study aims to find out if tiny plastic particles are present in children's bodies and if they are more common in kids with inflammatory bowel diseases like Crohn's or colitis. Researchers will analyze tissue, stool, blood, and urine samples from 40 children already scheduled…