ULCERATIVE COLITIS (UC)

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placeb…

This study tests a once-daily food supplement designed to improve gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual treatment. The goal is to see if the supplement hel…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This study tests whether adding selenium supplements to standard advanced therapies (like biologics) helps people with moderate to severe ulcerative colitis achieve remission. About 180 participants will receive either selenium or a placebo for a set period. The goal is to see if…

This study looks at the safety and effectiveness of Velsipity tablets taken daily for up to 52 weeks by people with moderate to severe ulcerative colitis. About 553 participants will be followed in real-world medical settings. The goal is to see if the drug can help control sympt…

This study looks at how well ozanimod works compared to azathioprine for people with steroid-dependent ulcerative colitis in Japan. Researchers will review medical records of 150 adults to see which drug helps patients stop steroids and stay symptom-free. The goal is to find a be…

This study tests a sequential treatment for moderate to severe ulcerative colitis. First, patients take upadacitinib (a fast-acting pill) along with vedolizumab (a slow but safe infusion) for 8 weeks to quickly reduce inflammation. Then, they continue with vedolizumab alone for l…

This study is testing whether a Mediterranean-like diet called Nordiet can improve gut health and reduce inflammation in 160 teens and adults with Crohn's disease or ulcerative colitis. Participants will follow the diet for four weeks while researchers check changes in gut bacter…

This study tests an oral biologic called MB-001 in 100 adults with moderate-to-severe ulcerative colitis. Participants take either MB-001 or a placebo daily for 12 weeks, then may continue in an open-label phase. Researchers will check for side effects and measure improvements in…

This Phase 2 study is testing two new drugs, MT-501 and MT-201, in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these treatments are safe and can improve symptoms and gut healing. Researchers will monitor side effects and measure…

This study tests an experimental drug called HSK47388 in 150 adults with moderately to severely active ulcerative colitis, a chronic bowel disease causing inflammation and sores. Participants will receive either the drug or a placebo to see if it improves symptoms and helps heal …

This study looks at whether using two drugs together (upadacitinib and vedolizumab) works better than just one drug (upadacitinib alone) for people with moderate-to-severe ulcerative colitis, a chronic bowel disease. Researchers will review medical records from 150 adults across …

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study tests a new drug called OD-07656 in people with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely reduces symptoms like bleeding and diarrhea, and if it can make a follow-up treatment (vedolizumab) work better. About 57 adu…

This study is testing whether adding the allergy medicine desloratadine to standard ulcerative colitis treatment can better control inflammation and symptoms. About 44 adults with mild to moderate ulcerative colitis will take either desloratadine plus mesalamine or mesalamine alo…

This study follows 500 people with ulcerative colitis who have already tried at least two advanced medications without success. Participants choose either to continue trying different medications or to have their colon removed (colectomy). Researchers will compare quality of life…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF therapy can improve outcomes for people with active Crohn's disease or ulcerative colitis. Eighty adults starting anti-TNF drugs will be randomly assigned to eithe…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This study tests whether taking vitamin D3 supplements can lower inflammation in people with moderate ulcerative colitis. Sixty adults aged 20-40 will either get standard care plus a placebo or standard care plus a high dose of vitamin D3 every two weeks for 12 weeks. Researchers…

This study compares two treatment approaches for people newly diagnosed with moderate-to-severe ulcerative colitis (UC). One group gets early treatment with mirikizumab, a biologic drug, while the other starts with standard azathioprine pills and can switch to mirikizumab later i…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study tests a new drug, BCD-261, in 198 adults with moderate to severe ulcerative colitis who haven't improved with standard treatments. Participants receive one of three doses of BCD-261 or a placebo as an injection. The goal is to see if the drug can reduce inflammation an…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study is looking for genetic clues that might predict how well people with inflammatory bowel disease (IBD) will respond to a common treatment called anti-TNF therapy. Researchers will collect blood samples from 40 patients who have not used anti-TNF before and track their r…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study looks at how much energy, water, and waste are used during different types of bowel imaging tests for people with ulcerative colitis or Crohn's disease. The goal is to see if a simple, non-invasive ultrasound can be a greener alternative to colonoscopy and CT scans. Ab…

This study looks at whether people with ulcerative colitis (UC) who are in deep remission (no signs of inflammation) can safely reduce or stop their medication. Researchers will compare two groups: those who continue their current therapy and those who decrease or stop it. The go…

This study looks at how gut bacteria change the energy use of immune cells in people with inflammatory bowel disease (IBD) and healthy adults. Researchers will give healthy volunteers a short course of antibiotics to alter their gut bacteria, then measure immune cell metabolism u…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (IBD) in Germany over many years. Its goal is to collect real-world information on how well treatments work, how the disease changes over time, and how it affects patients' daily lives. …

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…

This study looks at whether microplastics are found more often in children with inflammatory bowel disease (IBD) compared to healthy children. Researchers will collect samples of tissue, blood, urine, and stool from 40 children during routine endoscopy. No treatment is given—the …