ULCERATIVE COLITIS (UC)

This study looks at whether adding a second drug (vedolizumab) to the standard drug upadacitinib works better than upadacitinib alone for people with moderate-to-severe ulcerative colitis. Researchers will review medical records from 150 adults across six hospitals in China to se…

This study tests whether adding selenium supplements to standard advanced therapies (like biologics) can improve outcomes for people with moderate to severe ulcerative colitis. About 180 participants will receive either selenium or a placebo for a set period. The goal is to see i…

This study looks at people with ulcerative colitis whose disease is still active after trying at least two advanced medications. Participants choose either to continue trying different drugs or to have surgery to remove the colon. The goal is to see which option leads to better q…

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce how often they take the biologic drug ustekinumab. Researchers will monitor blood levels, inflammation, and gut health to see if a lower dose still keeps the …

This study looks at whether switching to a drug called guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who did not get enough relief from ustekinumab. About 200 adults across Canada will take guselkumab for one year, and doctors will track their symptom…

This study tests an experimental oral medication called MB-001 for people with moderate to severe ulcerative colitis. About 100 adults will take either MB-001 or a placebo daily for 12 weeks to see if it safely reduces symptoms and gut inflammation. After that, all participants c…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this t…

This study tests several new investigational drugs in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these drugs are safe and can improve symptoms and gut healing. Participants must have a confirmed diagnosis and meet disease activ…

This study looks at how well ozanimod works compared to azathioprine for people with steroid-dependent ulcerative colitis in Japan. Researchers will track 150 adults to see if they can achieve remission without needing steroids. The goal is to find a safer, more effective long-te…

This study is testing whether a smartphone app called SMART-IBD can help teenagers (ages 13-17) with inflammatory bowel disease (IBD) take their medications as prescribed and improve their self-management skills. The app includes daily symptom diaries, medication reminders, educa…

This study compares starting treatment with mirikizumab (a biologic drug) right away versus the usual step-up approach with azathioprine for people newly diagnosed with moderate-to-severe ulcerative colitis. About 300 adults will be randomly assigned to one of two groups and foll…

This large study will follow about 4,000 people who have had a fecal microbiota transplant (FMT) to see how well it works over time and if it's safe. FMT involves putting healthy donor stool into a patient's gut to restore good bacteria. The study looks at conditions like severe …

This study tests an oral medication called LY4268989 in adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. About 1,431 participants will receive either the drug or a placebo to see if it safely …

This study tests a new way to treat moderate to severe ulcerative colitis by using two drugs in sequence. First, a fast-acting drug (upadacitinib) is given for 8 weeks to quickly bring the disease under control, then patients switch to a safer long-term drug (vedolizumab) to keep…

This study tests whether adding high-dose vitamin D3 to standard treatment can lower inflammation in people with moderate ulcerative colitis. Sixty adults will take either vitamin D3 or a placebo for 12 weeks. Researchers will measure changes in blood and stool markers of inflamm…

This study is testing whether a Mediterranean-style diet (called 'Nordiet') can improve gut health and reduce inflammation in people with Crohn's disease or ulcerative colitis. Researchers will also look at how exercise, mental health, and quality of life affect disease activity.…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard anti-TNF medication helps people with active Crohn's disease or ulcerative colitis feel better faster. About 80 adults starting anti-TNF therapy will be randomly assigned to either receive…

This study tests a new drug called BCD-261 in about 198 adults with moderate to severe ulcerative colitis who haven't responded well to standard treatments. Participants will receive either BCD-261 or a placebo to see if the drug can reduce symptoms and inflammation. The goal is …

This study tests a new medicine called HSK47388 for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 150 adults who haven't gotten better with other treatments will receive either the drug or a placebo. The goal…

This study tests a new drug called OD-07656 in people with moderate to severe ulcerative colitis. The goal is to see if it is safe and can improve symptoms, and whether it can make a follow-up treatment (vedolizumab) work better. About 57 adults will take part in this early-stage…

This study tests a new drug called XmAb942 for people with moderate-to-severe ulcerative colitis, a condition that causes inflammation and sores in the colon. First, healthy volunteers will help check the drug's safety. Then, about 270 people with ulcerative colitis will receive …

This study tests whether a short educational video, along with handouts, can help children and teens with inflammatory bowel disease (IBD) eat fewer ultra-processed foods like packaged snacks and sugary drinks. About 120 participants will track their eating online and receive eit…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (meat-only) diet can improve quality of life and reduce symptoms in 160 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one…

This study tests whether adding the antihistamine desloratadine to standard mesalamine therapy can reduce inflammation and disease activity in people with mild-to-moderate ulcerative colitis. About 44 adults aged 18-65 who are already taking mesalamine will receive either deslora…

This study looks at how much energy, water, and waste are produced by different ways of imaging the bowel in people with ulcerative colitis or Crohn's disease. It compares a non-invasive ultrasound method with standard colonoscopy and CT scans. The goal is to see if the ultrasoun…

This study looks at how changes in gut bacteria may affect the energy use of immune cells in people with Inflammatory Bowel Disease (IBD). Researchers will compare healthy adults and IBD patients, giving healthy volunteers a short course of antibiotics to alter their gut bacteria…

This observational study looks for microplastics in children with and without inflammatory bowel disease (IBD). Researchers will collect tissue, stool, urine, and blood samples during routine procedures and use a special technique called Raman spectroscopy to detect and count mic…

This study looks at whether people with ulcerative colitis (UC) who have no signs of inflammation can safely lower or stop their medication. About 200 adults with UC in deep remission will either continue their current therapy or reduce/stop it, based on random assignment or pers…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis) in Germany. The goal is to collect real-world information on how the disease behaves, how well treatments work, and what c…