Could stopping acid reflux drugs improve IBD treatment?
NCT ID NCT07691138
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study explores whether people with inactive inflammatory bowel disease (IBD) can safely stop taking proton pump inhibitors (PPIs), a common acid-reducing medication. Evidence suggests PPIs may make IBD treatments less effective and increase hospital visits. The trial will recruit 80 participants aged 16 and older with stable IBD who have been on PPIs for over six months, randomly assigning half to stop the medication. Researchers will measure how many can successfully stop, how well they adhere, and whether IBD symptoms change over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Proton pump inhibitor (PPI) withdrawal
- What this could lead to
- If successful, this could show that stopping PPIs is safe and may improve how well IBD medications work, reducing the need for hospital care.
- What could go wrong
- This is a small feasibility study, not a large trial. Some people may experience a short-term increase in acid reflux after stopping PPIs, and it is unclear how many can stay off them long term.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Nottingham
RECRUITINGNottingham, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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