CROHN'S DISEASE

This program provides continued access to an investigational drug called vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. It is for participants who were already benefiting from the drug in a previous clinical study and have no…

This study is observing how safe and effective the approved medication upadacitinib is for people with moderate to severe Crohn's disease in real-world Japanese clinics. It will follow about 240 patients for up to 64 weeks as they take the drug as prescribed by their doctor. The …

This study is observing how well the drug guselkumab works for adults with moderate-to-severe Crohn's disease or ulcerative colitis in real-world UK clinics. It will track 220 patients to see if the treatment reduces symptoms, improves quality of life, and helps them stop using s…

This study is testing whether the drug guselkumab can heal all layers of the intestinal wall in people with active Crohn's disease. It will enroll about 112 participants who have not responded well to other treatments. Doctors will use MRI scans and other tests over 96 weeks to s…

This study is testing whether an investigational drug called SAR442970 can help control Crohn's disease symptoms and reduce intestinal inflammation. Adults with moderate to severe Crohn's disease who haven't responded well to standard treatments will receive either the drug or a …

This study is testing a two-part treatment for adults with moderate-to-severe Crohn's disease that isn't controlled by standard medicines. First, researchers want to see if a drug called vorinostat is safe and can reduce gut inflammation and symptoms. If it works, participants ma…

This study is testing whether a special liquid-only diet, called exclusive enteral nutrition (EEN), can help adults with active and complicated Crohn's disease. Researchers will follow 300 participants for 12 weeks to see if the diet reduces symptoms, improves gut health, and is …

This study is testing four different targeted therapies (risankizumab, trosunilimab, lutikizumab, and ABBV-8736) to see if they can help control moderate to severe Crohn's disease. The trial will enroll about 540 adults worldwide who haven't responded well to standard treatments.…

This study is testing if a newer surgical connection method (Kono-S) is better than the standard method at preventing Crohn's disease from returning after surgery to remove a diseased section of intestine. It will involve 600 adults with Crohn's who need their first surgery. Rese…

This study follows 400 people with Crohn's disease or ulcerative colitis who are starting treatment with guselkumab in real-world medical settings. The main goal is to see how well the drug controls symptoms like abdominal pain, diarrhea, and rectal bleeding, and to measure its i…

This trial is testing whether a patient's own filtered stem cells can 'reset' the immune system in people with severe Crohn's disease. After strong chemotherapy, doctors infuse specially selected stem cells back into the patient. The goal is to see if this approach can control th…

This study is testing whether adding a common antifungal medication (fluconazole) to standard Crohn's disease treatments improves patient outcomes. Researchers want to see if this combination helps control symptoms better than the standard treatments alone. The trial will involve…

This study is testing whether the medication mirikizumab can help control Crohn's disease in children and teenagers. About 90 participants with moderate to severe Crohn's disease who haven't responded well to other treatments will receive the drug for about 74 weeks. Researchers …

This study is testing whether an intravenous medication called vedolizumab can safely reduce symptoms and intestinal inflammation in Chinese adults with moderate to severe Crohn's disease. About 408 participants will receive either the drug or a placebo for 14 weeks, then all wil…

This study is testing if adding a specific diet to standard Crohn's disease medication helps children and teens stay in remission longer. It will compare the diet plus medication to medication alone over 12 months. The goal is to see if the diet can reduce painful flare-ups and p…

This study is testing whether an oral medication called upadacitinib can help control Crohn's disease in children aged 2 to 18 who haven't responded well to standard treatments. About 110 children worldwide will take the medication daily for up to 3 years while doctors monitor th…

This large, late-stage study is testing whether an investigational drug called tulisokibart can help control moderate to severe Crohn's disease. It will involve about 1200 people whose current treatments aren't working well enough. The main goal is to see if the drug is better th…

This study is monitoring the long-term safety and effectiveness of a cell-based injection (darvadstrocel) for treating complex anal fistulas in people with Crohn's disease. It will follow about 275 patients in Japan for three years after they receive the injection as part of thei…

This study is testing a drug called risankizumab in children and teenagers (ages 2 to 18) with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if the drug can safely reduce gut inflammation and control symptoms like abdominal …

This study is testing a medication called guselkumab to see if it can help children and teenagers with moderate to severe Crohn's disease. It aims to reduce their symptoms and heal the inflammation seen inside their intestines. The trial will involve about 120 young participants …

This study is testing whether using two different medications together works better than one alone for adults with moderate to severe Crohn's disease who haven't responded well to previous treatments. About 100 participants will first receive a combination of two drugs, then cont…

This study is monitoring the safety and real-world effectiveness of vedolizumab injections in 600 Korean adults with ulcerative colitis or Crohn's disease. Participants have already tried other treatments without success and are receiving vedolizumab as part of their regular care…

This study is testing whether adding a weight-loss drug (tirzepatide) to a Crohn's disease drug (mirikizumab) works better than the Crohn's drug alone. It's for adults who have active Crohn's disease and are also overweight or have obesity. The main goal is to see if the combinat…

This large, late-stage study is testing whether an investigational drug called duvakitug can help people with moderate to severe Crohn's disease stay in remission and reduce intestinal inflammation over the long term. About 671 participants who responded to the drug in a prior st…

This study aims to see how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. It is an extension study for about 150 young people who have already been taking…

This study is testing whether adding a psychological resilience program to standard biologic medication helps people with Crohn's disease achieve better long-term results. It will enroll 170 adults newly starting a biologic drug who have active Crohn's symptoms. The goal is to se…

This study is testing whether a new oral medication called TAK-279 can reduce inflammation and ulcers in the bowel for people with moderate to severe Crohn's disease. About 268 adults who haven't gotten enough relief from their current treatments will take one of three doses of T…

This study aims to learn about the long-term safety of vedolizumab injections in children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who responded well to the treatment in a previous study will continue receiving injections for up to 2 years, …

This study aims to test the safety and effectiveness of several new experimental drugs for adults with moderate-to-severe Crohn's disease or ulcerative colitis. It will enroll 140 participants to see if these treatments can reduce gut inflammation and control symptoms. The trial …

This study is testing whether a medication called vedolizumab, given as an injection under the skin, can help control symptoms and achieve remission in people with moderate to severe ulcerative colitis or Crohn's disease. About 400 participants will receive the treatment for abou…

This study is observing how well two already-approved medications work for people with moderate-to-severe Crohn's disease who did not get full relief from their first biologic treatment. It will follow 250 patients in Italy for up to 18 months as they take either upadacitinib or …

This study aims to check the long-term safety of an oral medication called zasocitinib (TAK-279) for adults with active Crohn's disease or ulcerative colitis. It is an extension for up to two years for people who benefited from the drug in earlier, shorter studies. The main goal …

This study is testing an experimental drug called AZD7798 to see if it is safe and can help heal the inflamed gut lining in people with active Crohn's disease. It will involve about 30 participants who have an ileostomy, allowing doctors to directly see the drug's effects. For th…

This study aims to find the best next step for Crohn's disease patients whose current medication (adalimumab) stops working effectively, even though drug levels in their blood remain adequate. Researchers will compare two approaches: switching to a different type of medication (v…

This large, late-stage study is testing an investigational drug called duvakitug for people with moderate-to-severe Crohn's disease who haven't responded well to other treatments. The main goal is to see if the drug can reduce symptoms and heal intestinal inflammation over 12 wee…

This study is testing a new drug called SAR441566 to see if it can help control Crohn's disease in adults. Researchers will compare different doses of the drug against a placebo to find the most effective and safe amount. The main goal is to see if the drug reduces inflammation i…

This study is testing an experimental medication called MORF-057 for adults with moderate to severe Crohn's disease. It aims to see if the drug can reduce intestinal inflammation and improve symptoms better than a placebo. Participants will receive either the study drug or a plac…

This study is testing a new under-the-skin injection form of the drug vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. About 70 participants who have already responded to the standard IV treatment will receive the injection for…

This study is testing a new type of PET scan to see if it can detect early scar tissue (fibrosis) in the small bowel of people with Crohn's disease. Researchers want to know if this scan can spot scarring before it causes a stricture, which is a dangerous narrowing of the intesti…

This study is testing a new, shorter version of an MRI scan used to check the intestines in people with Crohn's disease. The goal is to see if a 15-minute scan that doesn't use injected contrast dye works as well as the standard 60-minute scan. Researchers will enroll 300 childre…

This small pilot study from the Mayo Clinic is testing whether using virtual reality (VR) headsets can help reduce abdominal pain in people with Crohn's disease who still have pain even when tests show their inflammation is under control. About 15 participants will use a VR heads…

This study aims to understand how specific immune cells that respond to a protein called IL-23 are involved in Crohn's disease returning after surgery. Researchers will analyze tissue samples from 40 adult patients with recurring Crohn's disease before and after they receive stan…

This study aims to understand how quickly symptoms like pain, fatigue, and anxiety improve for people with Crohn's disease after starting specific biologic medications. Researchers will follow 300 adults who are beginning treatment with either vedolizumab or an IL-23 antagonist f…

This study aims to understand how doctors around the world use a specific treatment strategy for Crohn's Disease and Ulcerative Colitis, and whether using this strategy leads to better results for patients. It will look back at the medical records of 2,000 adults who have had the…

This study aims to understand how inflammatory bowel disease (IBD) like Crohn's and colitis affects pregnancy, and how pregnancy affects IBD. Researchers will review health records of 945 women with IBD who have been pregnant. The main goal is to count how often IBD symptoms flar…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…