Can a Weight-Loss drug boost Crohn's treatment? new trial aims to find out

NCT ID NCT06937099

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. The main goal is to see if more people achieve both gut healing and at least 10% weight loss with the combination.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mirikizumab and tirzepatide
What this could lead to: If successful, this could show that adding a weight-loss drug to a Crohn's treatment helps control both gut inflammation and weight, improving overall health.
What could go wrong: This is a mid-stage trial with 290 people, so results may not apply to everyone. Adding tirzepatide could cause side effects like nausea or vomiting, and it's unclear if the combination is better than mirikizumab alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE OBESITY OR OVERWEIGHT

Contacts and locations

Locations

(G.I.R.I.) GI Research Institute Foundation
RECRUITING

Vancouver, V5Z 2K5, Canada
AZ Groeninge Campus Kennedylaan
RECRUITING

Kortrijk, 8500, Belgium
AZORG Campus Aalst-Moorselbaan
RECRUITING

Aalst, 9300, Belgium
Aalborg Universitetshospital, Syd
RECRUITING

Gistrup, 9260, Denmark
Aarhus Universitetshospital, Skejby
RECRUITING

Aarhus, 8200, Denmark
Amsterdam UMC, locatie VUmc
RECRUITING

Amsterdam, 1081 HZ, Netherlands
Antalya Egitim ve Arastırma Hastanesi
RECRUITING

Muratpaşa, 07050, Turkey (Türkiye)
Assuta Ashdod Medical Center
RECRUITING

Ashdod, 7747629, Israel
Azienda Ospedale - Università Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56124, Italy
Bezmialem Vakf Üniversitesi
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Boca Clinical Trials Mexico S.C.
RECRUITING

Guadajalara, 44600, Mexico
Boca Clinical Trials Mexico SC
RECRUITING

Puebla City, 72160, Mexico
CEDOES
RECRUITING

Vitória, 29055450, Brazil
CEPIC - Centro Paulista de Investigação Clínica
RECRUITING

São Paulo, 04266-010, Brazil
CHD Vendee
RECRUITING

La Roche-sur-Yon, 85000, France
CHU Charles Nicolle
RECRUITING

Rouen, 76031, France
CHU Rangueil
RECRUITING

Toulouse, 31059, France
CLIAGEN Clínica de Atenção em Gastroenterologia, Especialidades e Nutrição
RECRUITING

Salvador, 41500-300, Brazil
CLINFAN Szolgáltató Kft
RECRUITING

Szekszárd, 7100, Hungary
CMRC Headlands, LLC
RECRUITING

San Juan, 00918, Puerto Rico
CPQuali Pesquisa Clínica
RECRUITING

São Paulo, 01228-000, Brazil
California Medical Research Associates
RECRUITING

Northridge, California, 91324, United States
Capital Digestive Care - Chevy Chase
RECRUITING

Chevy Chase, Maryland, 20815, United States
Care Access - New Iberia
RECRUITING

New Iberia, Louisiana, 70560, United States
Care Access - Yonkers
RECRUITING

Yonkers, New York, 10701, United States
Cedars-Sinai Medical Center
RECRUITING

Beverly Hills, California, 90211, United States
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
RECRUITING

Nice, 06202, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord
RECRUITING

Saint-Priest-en-Jarez, 42270, France
Centres Médico Chirurgicaux - Clinique Ambroise Paré
RECRUITING

Neuilly-sur-Seine, 92200, France
Centro Digestivo de Curitiba
RECRUITING

Curitiba, 80430-180, Brazil
Centro Médico Teknon
RECRUITING

Barcelona, 08022, Spain
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
RECRUITING

Ciudad Madero, 89440, Mexico
Centro de Investigacion Clinica Chapultepec
RECRUITING

Morelia, 58260, Mexico
Centro de Investigación Clinica Chapultepec
RECRUITING

Mexico City, 04100, Mexico
Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
NOT_YET_RECRUITING

Guadalajara, 44340, Mexico
Chu Saint Eloi
RECRUITING

Montpellier, 34295, France
Clinical Chc Montlégia
RECRUITING

Liège, 4000, Belgium
Clinical Research Institute S.C.
RECRUITING

Tlalnepantla, 54055, Mexico
Cliniq s.r.o.
RECRUITING

Bratislava, 81109, Slovakia
Clinique IMD
RECRUITING

Montreal, H3H 1E8, Canada
Clinique Pasteur
NOT_YET_RECRUITING

Toulouse, 31076, France
Clinique des Cèdres
RECRUITING

Échirolles, 38130, France
Clínica Hepatogastro JK
RECRUITING

São Paulo, 04543-011, Brazil
Coastal Research Institute - Fayetteville
RECRUITING

Fayetteville, North Carolina, 28304, United States
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Arquitecto Marcide
NOT_YET_RECRUITING

Ferrol, 15405, Spain
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, 31009, Spain
Constanta County Emergency Clinical Hospital Sf.Ap.Andrei
RECRUITING

Constanța, 900591, Romania
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Digestive Health Specialists
RECRUITING

Dothan, Alabama, 36301, United States
Digestive and Liver Center of Florida
RECRUITING

Orlando, Florida, 32825, United States
ENDOMED
RECRUITING

Košice, 040 13, Slovakia
ETG Zamość
RECRUITING

Zamość, 22-400, Poland
Edith Wolfson Medical Center
RECRUITING

Holon, 5810001, Israel
Ege Universitesi Hastanesi
RECRUITING

Izmir, 35100, Turkey (Türkiye)
EndoArt
RECRUITING

Ostrava, 710 00, Czechia
Erasmus Medisch Centrum
NOT_YET_RECRUITING

Rotterdam, 3015 GD, Netherlands
Eskisehir Osmangazi University
RECRUITING

Eskişehir, 26480, Turkey (Türkiye)
Eugastro GmbH
RECRUITING

Leipzig, 04103, Germany
Evangelismos General Hospital of Athens
RECRUITING

Athens, 106 76, Greece
FAICIC S. de R.L. de C.V.
NOT_YET_RECRUITING

Veracruz, 91900, Mexico
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
RECRUITING

Banská Bystrica, 97517, Slovakia
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Fundação Universidade de Caxias do Sul (FUCS)
RECRUITING

Caxias do Sul, 95070-560, Brazil
Galileo Medical Research
RECRUITING

Juiz de Fora, 36033-318, Brazil
Gastro Health Research - Miami
RECRUITING

Miami, Florida, 33176, United States
Gastro Health Research - Pensacola
RECRUITING

Pensacola, Florida, 32504, United States
Gastro Intestinal Research Institute of Northern Ohio, LLC
RECRUITING

Westlake, Ohio, 44145, United States
Gastro LM
RECRUITING

Prešov, 080 01, Slovakia
Gastroenterologie
RECRUITING

Hradec Králové, 500 02, Czechia
Gastroenterology Associates - Patewood
RECRUITING

Greenville, South Carolina, 29607, United States
Gastroenterology Center Of The Midsouth
RECRUITING

Cordova, Tennessee, 38018, United States
Gastroenterology Health Partners
RECRUITING

New Albany, Indiana, 47150, United States
Gastroenterology Health Partners
RECRUITING

Louisville, Kentucky, 40218, United States
Gastroenterology Research of San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Gastroenterology and internal medicine research institute
NOT_YET_RECRUITING

Edmonton, T5R 1W2, Canada
Gazi University Health Research and Application Center Gazi Hospital
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Grand Teton Research Group
RECRUITING

Idaho Falls, Idaho, 83404, United States
Health Pharma Querétaro
NOT_YET_RECRUITING

Juriquilla, 76230, Mexico
Herlev and Gentofte Hospital
RECRUITING

Copenhagen, 2730, Denmark
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28028, Spain
Hospital General de Occidente
NOT_YET_RECRUITING

Guadalajara, 45170, Mexico
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital de Cabueñes
RECRUITING

Gijón, 33394, Spain
Hospital de Clinicas de Porto Alegre
RECRUITING

Porto Alegre, 90035-903, Brazil
Hospital de Clínicas de Ribeirão Preto
RECRUITING

Ribeirão Preto, 14051-140, Brazil
Humanitas
RECRUITING

Rozzano, 20089, Italy
Hôpital Saint Antoine
RECRUITING

Paris, 75571, France
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy
IRMED
RECRUITING

Piotrkow Trybunalski, 97-300, Poland
ISCARE klinické centrum
RECRUITING

Prague, 19000, Czechia
Ikazia Ziekenhuis
RECRUITING

Rotterdam, 3083 AN, Netherlands
Indiana University Health University Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NOT_YET_RECRUITING

Mexico City, 14080, Mexico
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
NOT_YET_RECRUITING

Durango, 34000, Mexico
Integral Pesquisa e Ensino
RECRUITING

Votuporanga, 15500-269, Brazil
Ippokrateio General Hospital of Thessaloniki
RECRUITING

Thessaloniki, 54642, Greece
Klinikum Ernst von Bergmann
RECRUITING

Potsdam, 14467, Germany
Kocaeli University Medical Faculty Hospital
RECRUITING

İzmit, 41380, Turkey (Türkiye)
Korczowski Bartosz, Gabinet Lekarski
RECRUITING

Rzeszów, 35-302, Poland
L2IP - Instituto de Pesquisas Clínicas
RECRUITING

Brasília, 70200730, Brazil
Loema Instituto de Pesquisa Clinica
RECRUITING

Campinas, 13092-133, Brazil
London Digestive Disease Institute
RECRUITING

London, N6K 1M6, Canada
London Health Sciences Centre
RECRUITING

London, N6A 5W9, Canada
Louisiana Research Center
RECRUITING

Shreveport, Louisiana, 71105, United States
Lucida Clinical Trials
RECRUITING

New Bedford, Massachusetts, 02740, United States
Masarykova Nemocnice V Usti Nad Labem
RECRUITING

Ústí nad Labem, 40113, Czechia
Medical Care and Research SA de CV
RECRUITING

Mérida, 97070, Mexico
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
RECRUITING

Warsaw, 04-501, Poland
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Medizinische Universitaet Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Medizinische Universität Graz
RECRUITING

Graz, 8036, Austria
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Medrise Sp. z o.o.
RECRUITING

Lublin, 20-582, Poland
Melita Medical
RECRUITING

Wroclaw, 53-611, Poland
Mersin University
RECRUITING

Mersin, 33110, Turkey (Türkiye)
Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD
NOT_YET_RECRUITING

Sofia, 1233, Bulgaria
Mustafa Kemal Universitesi
RECRUITING

Hatay, 31030, Turkey (Türkiye)
NZOZ GynCentrum - Oddział Warszawa
RECRUITING

Warsaw, 00-124, Poland
New York Gastroenterology Associates
RECRUITING

New York, New York, 10075, United States
NewData Clinical Research - Aracaju
RECRUITING

Aracaju, 49075-000, Brazil
Odense Universitetshospital
RECRUITING

Odense, 5000, Denmark
Orlando Health
RECRUITING

Orlando, Florida, 32806, United States
Ospedale Di Circolo
RECRUITING

Rho, 20017, Italy
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Ospedale Specializzato in Gastroenterologia "Saverio de Bellis"
RECRUITING

Castellana Grotte, 70013, Italy
Pesquisare Saude
RECRUITING

Santo André, 09080-110, Brazil
Praxiszentrum für Gastroenterologie
RECRUITING

Grevenbroich, 41515, Germany
Precision Clinical Research
RECRUITING

Sunrise, Florida, 33351, United States
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Radboudumc
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
ResTrial GastroEndo s.r.o
RECRUITING

Prague, 143 00, Czechia
Research Associates of South Florida - Miami - Southwest 8th Street
RECRUITING

Miami, Florida, 33134, United States
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
RECRUITING

Timișoara, 300002, Romania
San Peregrino Unidad de Investigación
NOT_YET_RECRUITING

Aguascalientes, 20230, Mexico
Scientia Investigacion Clinica S.C.
RECRUITING

Chihuahua City, 31207, Mexico
Semmelweis Egyetem
RECRUITING

Budapest, 1082, Hungary
Semmelweis Egyetem
RECRUITING

Budapest, 1088, Hungary
Servicios de Oncología Médica Integral - Monterrey
RECRUITING

Monterrey, 66220, Mexico
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 5262100, Israel
Smart Cures Clinical Research
RECRUITING

Anaheim, California, 92806, United States
Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Southern Star Research Institute
RECRUITING

San Antonio, Texas, 78229, United States
Spitalul Clinic Colentina
RECRUITING

Bucharest, 020125, Romania
Spitalul Clinic Județean de Urgență
RECRUITING

Craiova, 200642, Romania
Spitalul Județean de Urgență Bacău
RECRUITING

Bacau, 600114, Romania
Spitalul Universitar de Urgență București
RECRUITING

Bucharest, 050098, Romania
Studiengesellschaft Mitteldeutschland GmbH
RECRUITING

Halle, 06108, Germany
SurGal Clinic
RECRUITING

Brno, 602 00, Czechia
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
RECRUITING

Szeged, 6725, Hungary
The Ottawa Hospital - General Campus
NOT_YET_RECRUITING

Ottawa, K1H 8L6, Canada
Thomas Jefferson University - Medicine/GI and Hepatology
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Thoracic General Hospital of Athens "I Sotiria"
RECRUITING

Athens, 115 27, Greece
Twoja Przychodnia Opolskie Centrum Medyczne
RECRUITING

Opole, 45-819, Poland
Twoja Przychodnia PCM
RECRUITING

Poznan, 60-324, Poland
Twoja Przychodnia SCM
RECRUITING

Szczecin, 71-434, Poland
Tyler Research Institute
RECRUITING

Tyler, Texas, 75701, United States
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Uludag Universitesi
RECRUITING

Bursa, 16059, Turkey (Türkiye)
United Medical Doctors - Los Alamitos
RECRUITING

Los Alamitos, California, 90720, United States
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University Gastroenterology
RECRUITING

Providence, Rhode Island, 02905, United States
University General Hospital of Heraklion
RECRUITING

Heraklion, 711 10, Greece
University Hospital "St. Ivan Rilski"
RECRUITING

Gorna Oryahovitsa, 5100, Bulgaria
University Multiprofile Hospital for Active Treatment "Tsaritsa Yoanna-ISUL" EAD
NOT_YET_RECRUITING

Sofia, 1527, Bulgaria
Universitätsklinikum Frankfurt Goethe-Universität
RECRUITING

Frankfurt, 60590, Germany
Université Libre de Bruxelles - Hôpital Erasme
RECRUITING

Brussels, 1070, Belgium
Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej
RECRUITING

Poznan, 60-354, Poland
Vancouver General Hospital
NOT_YET_RECRUITING

Vancouver, V5Z 1M9, Canada
Vejle Sygehus
RECRUITING

Vejle, 7100, Denmark
Vivamed Sp. z o.o.
RECRUITING

Warsaw, 03-580, Poland
Washington Gastroenterology - Tacoma
RECRUITING

Tacoma, Washington, 98405, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Wisconsin Center for Advanced Research
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Yitzhak Shamir Medical Center
RECRUITING

Ẕerifin, 7033001, Israel

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