Scientists hunt for immune culprits behind Crohn's Flare-Ups after surgery
NCT ID NCT06006039
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12-16 weeks of standard biologic treatment. The goal is to identify which cell types drive inflammation, which could help develop better therapies in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this research could reveal which immune cells are key targets for new Crohn's disease therapies, potentially leading to more effective treatments.
What could go wrong
This is a small, early-stage observational study (40 participants) designed to gather knowledge, not to test a treatment. It may not directly lead to new therapies.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC
RECRUITINGAmsterdam, North Holland, 1105, Netherlands
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mount Sinai
RECRUITINGToronto, Ontario, 1X5, Canada
Contact Email: •••••@•••••
Contact