Scientists hunt for immune culprits behind Crohn's Flare-Ups after surgery

NCT ID NCT06006039

Recruiting now Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12-16 weeks of standard biologic treatment. The goal is to identify which cell types drive inflammation, which could help develop better therapies in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal which immune cells are key targets for new Crohn's disease therapies, potentially leading to more effective treatments.
What could go wrong: This is a small, early-stage observational study (40 participants) designed to gather knowledge, not to test a treatment. It may not directly lead to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

Locations

Amsterdam UMC
RECRUITING

Amsterdam, North Holland, 1105, Netherlands
Mount Sinai
RECRUITING

Toronto, Ontario, 1X5, Canada

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