Can a biologic drug tame Crohn's without steroids? a large Real-World study investigates

NCT ID NCT07748338

Completed Disease control Sponsor: University Hospital Southampton NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study follows about 600 adults with Crohn's disease who are receiving ustekinumab (Stelara) as part of their routine care. The goal is to see how many achieve steroid-free remission after one year, using a standard symptom score. By including patients from both large research centers and smaller hospitals, the study aims to reflect real-world outcomes beyond clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ustekinumab (Stelara), a biologic drug given as an intravenous infusion followed by subcutaneous injections.
What this could lead to: If successful, this study could provide a clearer picture of how well ustekinumab works in everyday clinical practice, potentially guiding treatment decisions for Crohn's disease.
What could go wrong: As a real-world observational study, it doesn't prove cause and effect. Results may vary due to differences in patient populations and care settings, and the drug may not work for everyone.

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Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN'S DISEASE

Contacts and locations

Locations

Barnsley Hospital NHS Foundation Trust

Barnsley, South Yorkshire, S75 2EP, United Kingdom
Barts Health NHS Trust

London, Greater London, E1 1BB, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust

Bradford, West Yorkshire, BD9 6RJ, United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust

London, Greater London, SW10 9NH, United Kingdom
Dorset County Hospital NHS Foundation Trust

Dorchester, Dorset, DT1 2JY, United Kingdom
Guy's and St Thomas' NHS Foundation Trust

London, Greater London, SE1 9RT, United Kingdom
Hampshire Hospitals NHS Foundation Trust

Winchester, Hampshire, SO22 5DG, United Kingdom
Kingston Hospital NHS Foundation Trust

Kingston, Greater London, KT2 7QB, United Kingdom
Lewisham and Greenwich NHS Trust

London, Greater London, SE13 6LH, United Kingdom
Newcastle Hospitals NHS Foundation Trust

Newcastle, Tyne and Wear, NE1 4LP, United Kingdom
Pennine Acute Hospitals NHS Trust

Bury, Greater Manchester, BL9 7TD, United Kingdom
Royal United Hospitals Bath NHS Foundation Trust

Bath, Somerset, BA1 3NG, United Kingdom
Salford Royal NHS Foundation Trust

Salford, Greater Manchester, M6 8HD, United Kingdom
Salisbury NHS Foundation Trust

Salisbury, Wiltshire, SP2 8BJ, United Kingdom
St George's Hospital

London, Greater London, SW17 0QT, United Kingdom
St Mark's Hospital

Harrow, Middlesex, HA1 3UJ, United Kingdom
Swansea Bay University Health Board

Swansea, West Glamorgan, SA2 8QA, United Kingdom
University Hospital Southampton NHS Foundation Trust

Southampton, Hampshire, SO16 6YD, United Kingdom
University Hospital of Wales, Cardiff

Cardiff, South Glamorgan, CF14 4XW, United Kingdom
University Hospitals Bristol NHS Foundation Trust

Bristol, Bristol, BS2 8HW, United Kingdom
University Hospitals Dorset NHS Foundation Trust

Bournemouth, Dorset, BH7 7DW, United Kingdom
University Hospitals Sussex

Brighton, East Sussex, BN2 5NG, United Kingdom

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